Sean Humphrey
Sean Humphrey
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High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics
SJ Humphrey, SB Azimifar, M Mann
Nature Biotechnology 33, 990-995, 2015
Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2
SJ Humphrey, G Yang, P Yang, DJ Fazakerley, J Stöckli, JY Yang, ...
Cell metabolism 17 (6), 1009-1020, 2013
Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation
SJ Humphrey, DE James, M Mann
Trends in Endocrinology & Metabolism 26 (12), 676-687, 2015
Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates
NJ Hoffman, BL Parker, R Chaudhuri, KH Fisher-Wellman, M Kleinert, ...
Cell metabolism 22 (5), 922-935, 2015
A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation
G Yang, DS Murashige, SJ Humphrey, DE James
Cell reports 12 (6), 937-943, 2015
Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology
MS Robles, SJ Humphrey, M Mann
Cell Metabolism 25 (1), 118-127, 2017
High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform
SJ Humphrey, O Karayel, DE James, M Mann
Nature protocols 13 (9), 1897, 2018
Illuminating the dark phosphoproteome
EJ Needham, BL Parker, T Burykin, DE James, SJ Humphrey
Science signaling 12 (565), 2019
In vivo brain GPCR signaling elucidated by phosphoproteomics
JJ Liu, K Sharma, L Zangrandi, C Chen, SJ Humphrey, YT Chiu, M Spetea, ...
Science 360 (6395), 2018
Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance
DJ Fazakerley, R Chaudhuri, P Yang, GJ Maghzal, KC Thomas, JR Krycer, ...
eLife 7, e32111, 2018
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes
AY Minard, SX Tan, P Yang, DJ Fazakerley, W Domanova, BL Parker, ...
Cell Reports 17 (1), 29-36, 2016
Multi-Omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency
P Yang, SJ Humphrey, S Cinghu, R Pathania, AJ Oldfield, D Kumar, ...
Cell Systems, 2019
Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion
F Sacco, SJ Humphrey, J Cox, M Mischnik, A Schulte, T Klabunde, ...
Nature communications 7 (1), 1-13, 2016
Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry
BL Parker, G Yang, SJ Humphrey, R Chaudhuri, X Ma, S Peterman, ...
Science Signaling 8 (380), rs6-rs6, 2015
TBC1D13 is a RAB35 Specific GAP that Plays an Important Role in GLUT4 Trafficking in Adipocytes
JR Davey, SJ Humphrey, JR Junutula, AK Mishra, DG Lambright, ...
Traffic 13 (10), 1429-1441, 2012
Quantitative proteomic analysis of the adipocyte plasma membrane
MJ Prior, M Larance, RT Lawrence, J Soul, S Humphrey, J Burchfield, ...
Journal of proteome research 10 (11), 4970-4982, 2011
Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism
JR Krycer, K Yugi, A Hirayama, DJ Fazakerley, LE Quek, R Scalzo, ...
Cell Reports 21 (12), 3536-3547, 2017
Positive-unlabeled ensemble learning for kinase substrate prediction from dynamic phosphoproteomics data
P Yang, SJ Humphrey, DE James, YH Yang, R Jothi
Bioinformatics 32 (2), 252-259, 2016
Global redox proteome and phosphoproteome analysis reveals redox switch in Akt
Z Su, JG Burchfield, P Yang, SJ Humphrey, G Yang, D Francis, S Yasmin, ...
Nature Communications 10 (1), 1-18, 2019
Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets
F Sacco, A Seelig, SJ Humphrey, N Krahmer, F Volta, A Reggio, ...
Cell metabolism 29 (6), 1422-1432. e3, 2019
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