Richard Copin
Richard Copin
Associate Director at Regeneron Pharmaceuticals
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Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies
A Baum, BO Fulton, E Wloga, R Copin, KE Pascal, V Russo, S Giordano, ...
Science 369 (6506), 1014-1018, 2020
REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters
A Baum, D Ajithdoss, R Copin, A Zhou, K Lanza, N Negron, M Ni, Y Wei, ...
Science 370 (6520), 1110-1115, 2020
MyD88-dependent activation of B220− CD11b+ LY-6C+ dendritic cells during Brucella melitensis infection
R Copin, P De Baetselier, Y Carlier, JJ Letesson, E Muraille
The Journal of Immunology 178 (8), 5182-5191, 2007
The monoclonal antibody combination REGEN-COV protects against SARS-CoV-2 mutational escape in preclinical and human studies
R Copin, A Baum, E Wloga, KE Pascal, S Giordano, BO Fulton, A Zhou, ...
Cell 184 (15), 3949-3961. e11, 2021
Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets
DK Singh, B Singh, SR Ganatra, M Gazi, J Cole, R Thippeshappa, ...
Nature microbiology 6 (1), 73-86, 2021
M. tuberculosis T cell epitope analysis reveals paucity of antigenic variation and identifies rare variable TB antigens
M Coscolla, R Copin, J Sutherland, F Gehre, B de Jong, O Owolabi, ...
Cell host & microbe 18 (5), 538-548, 2015
In Situ Microscopy Analysis Reveals Local Innate Immune Response Developed around Brucella Infected Cells in Resistant and Susceptible Mice
R Copin, MA Vitry, D Hanot Mambres, A Machelart, C De Trez, ...
PLoS Pathogens 8 (3), e1002575, 2012
Sequence Diversity in the pe_pgrs Genes of Mycobacterium tuberculosis Is Independent of Human T Cell Recognition
R Copin, M Coscollá, SN Seiffert, G Bothamley, J Sutherland, G Mbayo, ...
MBio 5 (1), e00960-13, 2014
Impact of in vitro evolution on antigenic diversity of Mycobacterium bovis bacillus Calmette-Guerin (BCG)
R Copin, M Coscollá, E Efstathiadis, S Gagneux, JD Ernst
Vaccine 32 (45), 5998-6004, 2014
Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant Staphylococcus aureus
R Copin, WE Sause, Y Fulmer, D Balasubramanian, S Dyzenhaus, ...
Proceedings of the National Academy of Sciences 116 (5), 1745-1754, 2019
Functional characterization of the incomplete phosphotransferase system (PTS) of the intracellular pathogen Brucella melitensis
M Dozot, S Poncet, C Nicolas, R Copin, H Bouraoui, A Mazé, J Deutscher, ...
PLoS One 5 (9), e12679, 2010
The purine biosynthesis regulator PurR moonlights as a virulence regulator in Staphylococcus aureus
WE Sause, D Balasubramanian, I Irnov, R Copin, MJ Sullivan, ...
Proceedings of the National Academy of Sciences 116 (27), 13563-13572, 2019
In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection
DC Young, E Layre, SJ Pan, A Tapley, J Adamson, C Seshadri, Z Wu, ...
Chemistry & biology 22 (4), 516-526, 2015
Within host evolution selects for a dominant genotype of Mycobacterium tuberculosis while T cells increase pathogen genetic diversity
R Copin, X Wang, E Louie, V Escuyer, M Coscolla, S Gagneux, ...
PLoS pathogens 12 (12), e1006111, 2016
SARS-CoV-2 infection leads to acute infection with dynamic cellular and inflammatory flux in the lung that varies across nonhuman primate species
DK Singh, SR Ganatra, B Singh, J Cole, KJ Alfson, E Clemmons, M Gazi, ...
BioRxiv, 2020.06. 05.136481, 2020
Intracellular rescuing of a B. melitensis 16M virB mutant by co-infection with a wild type strain
C Nijskens, R Copin, X De Bolle, JJ Letesson
Microbial pathogenesis 45 (2), 134-141, 2008
After the deluge: Mining Staphylococcus aureus genomic data for clinical associations and host–pathogen interactions
R Copin, B Shopsin, VJ Torres
Current opinion in microbiology 41, 43-50, 2018
Using quantitative spectrometry to understand the influence of genetics and nutritional perturbations on the virulence potential of Staphylococcus aureus
JR Chapman, D Balasubramanian, K Tam, M Askenazi, R Copin, ...
Molecular & Cellular Proteomics 16 (4), S15-S28, 2017
Loss-of-Function Mutations in HspR Rescue the Growth Defect of a Mycobacterium tuberculosis Proteasome Accessory Factor E (pafE) Mutant
JB Jastrab, MI Samanovic, R Copin, B Shopsin, KH Darwin
Journal of Bacteriology 199 (7), e00850-16, 2017
In vitro and in vivo preclinical studies predict REGEN-COV protection against emergence of viral escape in humans
R Copin, A Baum, E Wloga, KE Pascal, S Giordano, BO Fulton, A Zhou, ...
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