| Repurposing high-throughput image assays enables biological activity prediction for drug discovery J Simm, G Klambauer, A Arany, M Steijaert, JK Wegner, E Gustin, ... Cell chemical biology 25 (5), 611-618. e3, 2018 | 215 | 2018 |
| Heteroaryl amines as glycogen synthase kinase 3β inhibitors (GSK3 inhibitors) EJE Freyne, PJJA Buijnsters, M Willems, WCJ Embrechts, CJ Love, ... US Patent 7,514,445, 2009 | 156 | 2009 |
| Oriented crystallization of calcium carbonate under self-organized monolayers of amide-containing phospholipids PJJA Buijnsters, JJJM Donners, SJ Hill, BR Heywood, RJM Nolte, ... Langmuir 17 (12), 3623-3628, 2001 | 100 | 2001 |
| Cationic gemini surfactants based on tartaric acid: synthesis, aggregation, monolayer behaviour, and interaction with DNA PJJA Buijnsters, CL García Rodríguez, EL Willighagen, ... European Journal of Organic Chemistry 2002 (8), 1397-1406, 2002 | 60 | 2002 |
| Pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines as Selective, Brain Penetrant Phosphodiesterase 2 (PDE2) Inhibitors FJR Rombouts, G Tresadern, P Buijnsters, X Langlois, F Tovar, ... ACS medicinal chemistry letters 6 (3), 282-286, 2015 | 56 | 2015 |
| Structure-based design of a potent, selective, and brain penetrating PDE2 inhibitor with demonstrated target engagement P Buijnsters, M De Angelis, X Langlois, FJR Rombouts, W Sanderson, ... ACS medicinal chemistry letters 5 (9), 1049-1053, 2014 | 45 | 2014 |
| Expression of supramolecular chirality in aggregates of chiral amide-containing surfactants NAJM Sommerdijk, PJJA Buijnsters, H Akdemir, DG Geurts, AMA Pistorius, ... Chemistry - A European Journal 4 (1), 127-136, 1998 | 38 | 1998 |
| Aziridines as Precursors for Chiral Amide-Containing Surfactants NAJM Sommerdijk, PJJA Buijnsters, H Akdemir, DG Geurts, RJM Nolte, ... J, Org. Chem 62 (15), 4955=4960, 1997 | 35 | 1997 |
| Discovery of a new series of [1, 2, 4] triazolo [4, 3-a] quinoxalines as dual phosphodiesterase 2/phosphodiesterase 10 (PDE2/PDE10) inhibitors JI Andrés, P Buijnsters, M De Angelis, X Langlois, F Rombouts, ... Bioorganic & medicinal chemistry letters 23 (3), 785-790, 2013 | 29 | 2013 |
| Aminobenzamide derivatives as glycogen synthase kinase 3 beta inhibitors EJ Freyne, P Antonius, M Willems, W Johan, P Janssen, P Joannes, ... US Patent App. 10/493,446, 2006 | 29 | 2006 |
| Towards selective phosphodiesterase 2A (PDE2A) inhibitors: a patent review (2010-present) AA Trabanco, P Buijnsters, FJR Rombouts Expert opinion on therapeutic patents 26 (8), 933-946, 2016 | 28 | 2016 |
| O-GlcNAcase inhibitors as potential therapeutics for the treatment of Alzheimer’s disease and related tauopathies: analysis of the patent literature JM Bartolomé-Nebreda, AA Trabanco, AI Velter, P Buijnsters Expert opinion on therapeutic patents 31 (12), 1117-1154, 2021 | 26 | 2021 |
| Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors EJE Freyne, CJ Love, LP Cooymans, N Vandermaesen, PJJA Buijnsters, ... US Patent 7,449,465, 2008 | 18 | 2008 |
| 1, 3, 4-Oxadiazole and heteroaromatic-fused 1, 2, 4-triazole synthesis using diverted umpolung amide synthesis K Tokumaru, K Bera, JN Johnston Synthesis 49 (20), 4670-4675, 2017 | 16 | 2017 |
| [1,2,4]Triazolo[1,5-a]pyrimidine Phosphodiesterase 2A Inhibitors: Structure and Free-Energy Perturbation-Guided Exploration G Tresadern, I Velter, AA Trabanco, F Van den Keybus, GJ Macdonald, ... Journal of Medicinal Chemistry 63 (21), 12887-12910, 2020 | 15 | 2020 |
| Macrocyclic quinazoline derivatives as antiproliferative agents EJE Freyne, TPS Perera, PJJA Buijnsters, M Willems, GSM Diels, ... US Patent 7,648,975, 2010 | 14 | 2010 |
| Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors EJE Freyne, CJ Love, LP Cooymans, N Vandermaesen, PJJA Buijnsters, ... US Patent 7,560,458, 2009 | 14 | 2009 |
| Quinazoline derivatives EJE Freyne, TPS Perera, PJJA Buijnsters, M Willems, GSM Diels, ... US Patent 8,394,786, 2013 | 12 | 2013 |
| Amide derivatives as glycogen synthase kinase 3-β inhibitors EJE Freyne, PJJA Buijnsters, M Willems, WCJ Embrechts, JFA Lacrampe, ... US Patent 7,183,288, 2007 | 11 | 2007 |
| 3-cyano-quinoline derivatives with antiproliferative activity EJE Freyne, PJJ Buijnsters, K Van Emelen, WCJ Embrechts, TPS Perera US Patent 7,655,642, 2010 | 10 | 2010 |
Nico SommerdijkRadboud University Medical Center, Nijmegen-NLVerified email at radboudumc.nl
