Tudor Oprea

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Cristian BologaResearch Professor, University of New MexicoVerified email at salud.unm.edu
Oleg UrsuMerck & Co., Inc.Verified email at merck.com
Eric R. ProssnitzDistinguished Professor & Chief, Div. of Molecular Medicine, Dept. of Internal Medicine, UNMVerified email at salud.unm.edu
Jeremy J YangUniversity of New MexicoVerified email at salud.unm.edu
Liliana Ostopovici-HalipThe Institute of Chemistry, TimisoaraVerified email at acad-icht.tm.edu.ro
Garland R. MarshallProfesso of Biochemistry and Molecular Biophysics, Washington UniversityVerified email at biochem.wustl.edu
Andrei LeitãoProfessor Doutor - Instituto de Química de São Carlos, Universidade de São PauloVerified email at iqsc.usp.br
Paul LeesonPaul Leeson Consulting LtdVerified email at nottingham.ac.uk
Ramona CurpanResearcher, Institute of Chemistry Timisoara of Romanian AcademyVerified email at acad-icht.tm.edu.ro
Stephen L MathiasSr Research Scientist, University of New Mexico Translational Informatics DivisionVerified email at swcp.com
Andrew M DavisAstraZeneca, Fisons, Astra, University of KentVerified email at astrazeneca.com
Alexander TropshaProfessor at UNC-Chapel HillVerified email at unc.edu
Benet lzUCSFVerified email at ucsf.edu
Fabio BroccatelliScientist at GenentechVerified email at gene.com
Søren BrunakProfessor of Disease Systems Biology, University of CopenhagenVerified email at cpr.ku.dk
Lars Juhl JensenUniversity of CopenhagenVerified email at cpr.ku.dk
Jordi MestresIMIM Hospital del Mar Medical Research InstituteVerified email at imim.es
Chetana RevankarSenior Scientist and ManagerVerified email at lifetech.com
Ramesh ChinnasamyCollege Assistant Professor, Chemistry, New Mexico State UniversityVerified email at nmsu.edu
John P. OveringtonExscientiaVerified email at exscientia.co.uk

Tudor Oprea

Professor and Chief, Translational Informatics Division, UNM School

Verified email at salud.unm.edu - Homepage

virtual screening cheminformatics drug repositioning AI drug discovery


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A comprehensive map of molecular drug targets R Santos, O Ursu, A Gaulton, AP Bento, RS Donadi, CG Bologa, ... Nature reviews Drug discovery 16 (1), 19-34, 2017	1185	2017
Is There a Difference Between Leads and Drugs? A Historical Perspective. TI Oprea, AM Davis, SJ Teague, PD Leeson Journal of chemical information and computer sciences 41 (5), 1308-1315, 2001	924	2001
The design of leadlike combinatorial libraries SJ Teague, AM Davis, PD Leeson, T Oprea Angewandte Chemie International Edition 38 (24), 3743-3748, 1999	855	1999
Virtual and biomolecular screening converge on a selective agonist for GPR30 CG Bologa, CM Revankar, SM Young, BS Edwards, JB Arterburn, ... Nature chemical biology 2 (4), 207-212, 2006	806	2006
Estrogen signaling through the transmembrane G protein–coupled receptor GPR30 ER Prossnitz, JB Arterburn, HO Smith, TI Oprea, LA Sklar, HJ Hathaway Annu. Rev. Physiol. 70, 165-190, 2008	675	2008
Property distribution of drug-related chemical databases TI Oprea Journal of computer-aided molecular design 14 (3), 251-264, 2000	647	2000
Pursuing the leadlikeness concept in pharmaceutical research MM Hann, TI Oprea Current opinion in chemical biology 8 (3), 255-263, 2004	572	2004
BDDCS applied to over 900 drugs LZ Benet, F Broccatelli, TI Oprea The AAPS journal 13 (4), 519-547, 2011	546	2011
In vivo effects of a GPR30 antagonist MK Dennis, R Burai, C Ramesh, WK Petrie, SN Alcon, TK Nayak, ... Nature chemical biology 5 (6), 421-427, 2009	514	2009
Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system E Brailoiu, SL Dun, GC Brailoiu, K Mizuo, LA Sklar, TI Oprea, ER Prossnitz, ... Journal of endocrinology 193 (2), 311-321, 2007	507	2007
G protein–coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17β-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells L Albanito, A Madeo, R Lappano, A Vivacqua, V Rago, A Carpino, ... Cancer research 67 (4), 1859-1866, 2007	464	2007
Chemography: the art of navigating in chemical space TI Oprea, J Gottfries Journal of combinatorial chemistry 3 (2), 157-166, 2001	347	2001
Integrating virtual screening in lead discovery TI Oprea, H Matter Current opinion in chemical biology 8 (4), 349-358, 2004	338	2004
VALIDATE: A new method for the receptor-based prediction of binding affinities of novel ligands RD Head, ML Smythe, TI Oprea, CL Waller, SM Green, GR Marshall Journal of the American Chemical society 118 (16), 3959-3969, 1996	328	1996
Current trends in lead discovery: Are we looking at the appropriate property TI Oprea Journal of computer-aided molecular design 16 (5-6), 325-334, 2002	298*	2002
Novel chemical space exploration via natural products J Rosén, J Gottfries, S Muresan, A Backlund, TI Oprea Journal of medicinal chemistry 52 (7), 1953-1962, 2009	278	2009
Temporal disease trajectories condensed from population-wide registry data covering 6.2 million patients AB Jensen, PL Moseley, TI Oprea, SG Ellesøe, R Eriksson, H Schmock, ... Nature communications 5 (1), 1-10, 2014	270	2014
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity MK Dennis, AS Field, R Burai, C Ramesh, WK Petrie, CG Bologa, ... The Journal of steroid biochemistry and molecular biology 127 (3-5), 358-366, 2011	261	2011
Drug repurposing from an academic perspective TI Oprea, JE Bauman, CG Bologa, T Buranda, A Chigaev, BS Edwards, ... Drug Discovery Today: Therapeutic Strategies 8 (3-4), 61-69, 2011	260	2011
The G protein–coupled receptor GPR30 inhibits proliferation of estrogen receptor–positive breast cancer cells EA Ariazi, E Brailoiu, S Yerrum, HA Shupp, MJ Slifker, HE Cunliffe, ... Cancer research 70 (3), 1184-1194, 2010	251	2010

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