Jean Lou Dorne
Jean Lou Dorne
Senior Scientific Officer, EFSA
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Systems toxicology approaches for understanding the joint effects of environmental chemical mixtures
DJ Spurgeon, OAH Jones, JLCM Dorne, C Svendsen, S Swain, ...
Science of the total environment 408 (18), 3725-3734, 2010
Risk assessment of coccidostatics during feed cross-contamination: animal and human health aspects
J Dorne, ML Fernández-Cruz, U Bertelsen, DW Renshaw, K Peltonen, ...
Toxicology and applied pharmacology 270 (3), 196-208, 2013
The refinement of uncertainty/safety factors in risk assessment by the incorporation of data on toxicokinetic variability in humans
J Dorne, AG Renwick
Toxicological Sciences 86 (1), 20-26, 2005
An analysis of the need for an additional uncertainty factor for infants and children
AG Renwick, JL Dorne, K Walton
Regulatory Toxicology and Pharmacology 31 (3), 286-296, 2000
Human variability in xenobiotic metabolism and pathway-related uncertainty factors for chemical risk assessment: a review
J Dorne, K Walton, AG Renwick
Food and chemical toxicology 43 (2), 203-216, 2005
Nitrite in feed: from animal health to human health
A Cockburn, G Brambilla, ML Fernández, D Arcella, LR Bordajandi, ...
Toxicology and applied pharmacology 270 (3), 209-217, 2013
Recent advances in the risk assessment of melamine and cyanuric acid in animal feed
JL Dorne, DR Doerge, M Vandenbroeck, J Fink-Gremmels, W Mennes, ...
Toxicology and applied pharmacology 270 (3), 218-229, 2013
Current EU research activities on combined exposure to multiple chemicals
SK Bopp, R Barouki, W Brack, S Dalla Costa, JLCM Dorne, PE Drakvik, ...
Environment international 120, 544-562, 2018
Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment
J Dorne, K Walton, AG Renwick
Food and Chemical Toxicology 41 (2), 201-224, 2003
Guidance on the use of the weight of evidence approach in scientific assessments
EFSA Scientific Committee, A Hardy, D Benford, T Halldorsson, MJ Jeger, ...
EFSA Journal 15 (8), e04971, 2017
Uncertainty factors for chemical risk assessment: human variability in the pharmacokinetics of CYP1A2 probe substrates
J Dorne, K Walton, AG Renwick
Food and Chemical Toxicology 39 (7), 681-696, 2001
Human risk assessment of heavy metals: principles and applications
JL Dorne, GE Kass, LR Bordajandi, B Amzal, U Bertelsen, AF Castoldi, ...
Met Ions Life Sci 8 (4), 27-60, 2011
Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates
K Walton, JL Dorne, AG Renwick
Food and Chemical Toxicology 39 (7), 667-680, 2001
Guidance on harmonised methodologies for human health, animal health and ecological risk assessment of combined exposure to multiple chemicals
SJ More, V Bampidis, D Benford, SH Bennekou, C Bragard, ...
Efsa journal 17 (3), 2019
The effects on terrestrial invertebrates of reducing pesticide inputs in arable crop edges: a meta‐analysis
GK Frampton, JLCM Dorne
Journal of Applied Ecology 44 (2), 362-373, 2007
Human and environmental risk assessment of pharmaceuticals: differences, similarities, lessons from toxicology
J Dorne, L Skinner, GK Frampton, DJ Spurgeon, AMJ Ragas
Analytical and Bioanalytical Chemistry 387 (4), 1259-1268, 2007
Comparative toxicity of pesticides and environmental contaminants in bees: are honey bees a useful proxy for wild bee species?
MS Heard, J Baas, JL Dorne, E Lahive, AG Robinson, A Rortais, ...
Science of the Total Environment 578, 357-365, 2017
Combining analytical techniques, exposure assessment and biological effects for risk assessment of chemicals in food
J Dorne, LR Bordajandi, B Amzal, P Ferrari, P Verger
TrAC Trends in Analytical Chemistry 28 (6), 695-707, 2009
Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate?
J Dorne, K Walton, W Slob, AG Renwick
Food and Chemical Toxicology 40 (11), 1633-1656, 2002
Metabolism, variability and risk assessment
J Dorne
Toxicology 268 (3), 156-164, 2010
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