| Small-molecule inhibition of APT1 affects Ras localization and signaling FJ Dekker, O Rocks, N Vartak, S Menninger, C Hedberg, R Balamurugan, ... Nature chemical biology 6 (6), 449, 2010 | 321 | 2010 |
| Natural-product-derived fragments for fragment-based ligand discovery B Over, S Wetzel, C Grütter, Y Nakai, S Renner, D Rauh, H Waldmann Nature chemistry 5 (1), 21-28, 2013 | 227 | 2013 |
| Interactive exploration of chemical space with Scaffold Hunter S Wetzel, K Klein, S Renner, D Rauh, TI Oprea, P Mutzel, H Waldmann Nature chemical biology 5 (8), 581-583, 2009 | 223 | 2009 |
| Scaffold‐hopping: how far can you jump? G Schneider, P Schneider, S Renner Qsar & Combinatorial Science 25 (12), 1162-1171, 2006 | 141 | 2006 |
| Bioactivity-guided mapping and navigation of chemical space S Renner, WAL Van Otterlo, MD Seoane, S Möcklinghoff, B Hofmann, ... Nature chemical biology 5 (8), 585-592, 2009 | 132 | 2009 |
| Comparison of correlation vector methods for ligand-based similarity searching U Fechner, L Franke, S Renner, P Schneider, G Schneider Journal of computer-aided molecular design 17 (10), 687-698, 2003 | 116 | 2003 |
| Scaffold‐hopping potential of ligand‐based similarity concepts S Renner, G Schneider ChemMedChem: Chemistry Enabling Drug Discovery 1 (2), 181-185, 2006 | 107 | 2006 |
| A Collection of Robust Organic Synthesis Reactions for In Silico Molecule Design M Hartenfeller, M Eberle, P Meier, C Nieto-Oberhuber, KH Altmann, ... Journal of chemical information and modeling 51 (12), 3093-3098, 2011 | 81 | 2011 |
| Total synthesis of chondramide C and its binding mode to F‐actin H Waldmann, TS Hu, S Renner, S Menninger, R Tannert, T Oda, HD Arndt Angewandte Chemie International Edition 47 (34), 6473-6477, 2008 | 78 | 2008 |
| Mining for bioactive scaffolds with scaffold networks: improved compound set enrichment from primary screening data T Varin, A Schuffenhauer, P Ertl, S Renner Journal of chemical information and modeling 51 (7), 1528-1538, 2011 | 70 | 2011 |
| Development of highly potent inhibitors of the Ras‐targeting human acyl protein thioesterases based on substrate similarity design C Hedberg, FJ Dekker, M Rusch, S Renner, S Wetzel, N Vartak, ... Angewandte Chemie International Edition 50 (42), 9832-9837, 2011 | 68 | 2011 |
| Homology model-based virtual screening for GPCR ligands using docking and target-biased scoring T Weil, S Renner Journal of chemical information and modeling 48 (5), 1104-1117, 2008 | 68 | 2008 |
| Fuzzy pharmacophore models from molecular alignments for correlation-vector-based virtual screening S Renner, G Schneider Journal of medicinal chemistry 47 (19), 4653-4664, 2004 | 67 | 2004 |
| Positive and negative modulation of group I metabotropic glutamate receptors M Vanejevs, C Jatzke, S Renner, S Müller, M Hechenberger, T Bauer, ... Journal of medicinal chemistry 51 (3), 634-647, 2008 | 61 | 2008 |
| Anticancer properties of an important drug lead podophyllotoxin can be efficiently mimicked by diverse heterocyclic scaffolds accessible via one-step synthesis IV Magedov, L Frolova, M Manpadi, U Bhoga, H Tang, NM Evdokimov, ... Journal of medicinal chemistry 54 (12), 4234-4246, 2011 | 57 | 2011 |
| Recent trends and observations in the design of high-quality screening collections S Renner, M Popov, A Schuffenhauer, HJ Roth, W Breitenstein, ... Future medicinal chemistry 3 (6), 751-766, 2011 | 56 | 2011 |
| Impact of conformational flexibility on three-dimensional similarity searching using correlation vectors S Renner, CH Schwab, J Gasteiger, G Schneider Journal of chemical information and modeling 46 (6), 2324-2332, 2006 | 54 | 2006 |
| A Scaffold‐Tree‐Merging Strategy for Prospective Bioactivity Annotation of γ‐Pyrones S Wetzel, W Wilk, S Chammaa, B Sperl, AG Roth, A Yektaoglu, S Renner, ... Angewandte Chemie 122 (21), 3748-3752, 2010 | 49 | 2010 |
| Maximum common binding modes (MCBM): consensus docking scoring using multiple ligand information and interaction fingerprints S Renner, S Derksen, S Radestock, F Mörchen Journal of chemical information and modeling 48 (2), 319-332, 2008 | 49 | 2008 |
| DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery C Ye, DJ Ho, M Neri, C Yang, T Kulkarni, R Randhawa, M Henault, ... Nature communications 9 (1), 1-9, 2018 | 48 | 2018 |
Gisbert SchneiderETH ZurichVerified email at ethz.ch
