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Lydia Lynch
Lydia Lynch
Harvard Medical School
Adresse e-mail validée de bwh.harvard.edu
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Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production
L Lynch, M Nowak, B Varghese, J Clark, AE Hogan, V Toxavidis, SP Balk, ...
Immunity 37 (3), 574-587, 2012
5442012
Metabolic reprogramming of natural killer cells in obesity limits antitumor responses
X Michelet, L Dyck, A Hogan, RM Loftus, D Duquette, K Wei, S Beyaz, ...
Nature immunology 19 (12), 1330-1340, 2018
4932018
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer
D Wu, D Hu, H Chen, G Shi, IS Fetahu, F Wu, K Rabidou, R Fang, L Tan, ...
Nature 559 (7715), 637-641, 2018
3892018
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue
L Lynch, X Michelet, S Zhang, PJ Brennan, A Moseman, C Lester, ...
Nature immunology 16 (1), 85-95, 2015
3802015
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue
L Lynch, X Michelet, S Zhang, PJ Brennan, A Moseman, C Lester, ...
Nature immunology 16 (1), 85, 2015
3802015
Clinical anxiety, cortisol and interleukin-6: Evidence for specificity in emotion–biology relationships
A O’Donovan, BM Hughes, GM Slavich, L Lynch, MT Cronin, C O’Farrelly, ...
Brain, behavior, and immunity 24 (7), 1074-1077, 2010
3382010
Srebp-controlled glucose metabolism is essential for NK cell functional responses
N Assmann, KL O'Brien, RP Donnelly, L Dyck, V Zaiatz-Bittencourt, ...
Nature immunology 18 (11), 1197-1206, 2017
3132017
γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis
AC Kohlgruber, ST Gal-Oz, NM LaMarche, M Shimazaki, D Duquette, ...
Nature immunology 19 (5), 464-474, 2018
3082018
Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity
L Lynch, D O'Shea, DC Winter, J Geoghegan, DG Doherty, C O'Farrelly
European journal of immunology 39 (7), 1893-1901, 2009
3022009
Interplay between the immune system and adipose tissue in obesity
MA Exley, L Hand, D O'Shea, L Lynch
Journal of Endocrinology 223 (2), R41-R48, 2014
2992014
Are Natural Killer Cells Protecting the Metabolically Healthy Obese Patient&quest
LA Lynch, JM O'Connell, AK Kwasnik, TJ Cawood, C O'Farrelly, ...
Obesity 17 (3), 601-605, 2008
2882008
The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity
J O'Connell, L Lynch, TJ Cawood, A Kwasnik, N Nolan, J Geoghegan, ...
PloS one 5 (4), e9997, 2010
2762010
Lactate-mediated acidification of tumor microenvironment induces apoptosis of liver-resident NK cells in colorectal liver metastasis
C Harmon, MW Robinson, F Hand, D Almuaili, K Mentor, DD Houlihan, ...
Cancer immunology research 7 (2), 335-346, 2019
2382019
Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus
AE Hogan, G Gaoatswe, L Lynch, MA Corrigan, C Woods, J O’Connell, ...
Diabetologia 57 (4), 781-784, 2014
2082014
Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity
S Boulenouar, X Michelet, D Duquette, D Alvarez, AE Hogan, C Dold, ...
Immunity 46 (2), 273-286, 2017
1962017
Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke
D O'Shea, TJ Cawood, C O'Farrelly, L Lynch
PloS one 5 (1), e8660, 2010
1872010
Adipose tissue inflammation in the pathogenesis of type 2 diabetes
A Kohlgruber, L Lynch
Current diabetes reports 15 (11), 92, 2015
1832015
iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy
L Lynch, AE Hogan, D Duquette, C Lester, A Banks, K LeClair, DE Cohen, ...
Cell Metabolism 24 (3), 510-519, 2016
1822016
Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity
E Carolan, LM Tobin, BA Mangan, M Corrigan, G Gaoatswe, G Byrne, ...
The Journal of Immunology, 1402945, 2015
1802015
Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis
AE Hogan, AM Tobin, T Ahern, MA Corrigan, G Gaoatswe, R Jackson, ...
Diabetologia 54 (11), 2745-2754, 2011
1802011
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