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| Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor NM King, M Prabu-Jeyabalan, EA Nalivaika, P Wigerinck, MP de Béthune, ... Journal of virology 78 (21), 12012-12021, 2004 | 263 | 2004 |
| Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor DLNG Surleraux, A Tahri, WG Verschueren, GME Pille, HA De Kock, ... Journal of medicinal chemistry 48 (6), 1813-1822, 2005 | 262 | 2005 |
| Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments TD Wu, CA Schiffer, MJ Gonzales, J Taylor, R Kantor, S Chou, D Israelski, ... Journal of virology 77 (8), 4836-4847, 2003 | 251 | 2003 |
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| Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding KP Romano, A Ali, WE Royer, CA Schiffer Proceedings of the National Academy of Sciences 107 (49), 20986-20991, 2010 | 184 | 2010 |
| The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors KP Romano, A Ali, C Aydin, D Soumana, A Özen, LM Deveau, C Silver, ... PLoS pathogens 8 (7), 2012 | 178 | 2012 |
| Combating susceptibility to drug resistance: lessons from HIV-1 protease NM King, M Prabu-Jeyabalan, EA Nalivaika, CA Schiffer Chemistry & biology 11 (10), 1333-1338, 2004 | 138 | 2004 |
| Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site CA Schiffer, IJ Clifton, VJ Davisson, DV Santi, RM Stroud Biochemistry 34 (50), 16279-16287, 1995 | 129 | 1995 |
| Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces SMD Shandilya, MNL Nalam, EA Nalivaika, PJ Gross, JC Valesano, ... Structure 18 (1), 28-38, 2010 | 127 | 2010 |
| Molecular basis for drug resistance in HIV-1 protease A Ali, RM Bandaranayake, Y Cai, NM King, M Kolli, S Mittal, JF Murzycki, ... Viruses 2 (11), 2509-2535, 2010 | 125 | 2010 |
| HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants MD Altman, A Ali, GSK Kumar Reddy, MNL Nalam, SG Anjum, H Cao, ... Journal of the American Chemical Society 130 (19), 6099-6113, 2008 | 124 | 2008 |
| PTEN enters the nucleus by diffusion F Liu, S Wagner, RB Campbell, JA Nickerson, CA Schiffer, AH Ross Journal of cellular biochemistry 96 (2), 221-234, 2005 | 120 | 2005 |
| Replacement of the P1 amino acid of human immunodeficiency virus type 1 Gag processing sites can inhibit or enhance the rate of cleavage by the viral protease SC Pettit, GJ Henderson, CA Schiffer, R Swanstrom Journal of virology 76 (20), 10226-10233, 2002 | 118 | 2002 |
| Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy M Prabu-Jeyabalan, EA Nalivaika, NM King, CA Schiffer Journal of virology 77 (2), 1306-1315, 2003 | 112 | 2003 |
| Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy M Prabu-Jeyabalan, EA Nalivaika, NM King, CA Schiffer Journal of virology 77 (2), 1306-1315, 2003 | 112 | 2003 |
| Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A MA Carpenter, M Li, A Rathore, L Lackey, EK Law, AM Land, B Leonard, ... Journal of Biological Chemistry 287 (41), 34801-34808, 2012 | 111 | 2012 |
| Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5 W Chen, SS Lam, H Srinath, Z Jiang, JJ Correia, CA Schiffer, ... Nature structural & molecular biology 15 (11), 1213, 2008 | 107 | 2008 |
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