| Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug–drug interactions M Karlgren, A Vildhede, U Norinder, JR Wisniewski, E Kimoto, Y Lai, ... Journal of medicinal chemistry 55 (10), 4740-4763, 2012 | 374 | 2012 |
| Development of a new permeability assay using low‐efflux MDCKII cells L Di, C Whitney‐Pickett, JP Umland, H Zhang, X Zhang, DF Gebhard, ... Journal of pharmaceutical sciences 100 (11), 4974-4985, 2011 | 277 | 2011 |
| Protein abundance of clinically relevant multidrug transporters along the entire length of the human intestine M Drozdzik, C Gröer, J Penski, J Lapczuk, M Ostrowski, Y Lai, B Prasad, ... Molecular pharmaceutics 11 (10), 3547-3555, 2014 | 273 | 2014 |
| In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development KLR Brouwer, D Keppler, KA Hoffmaster, DAJ Bow, Y Cheng, Y Lai, ... Clinical Pharmacology & Therapeutics 94 (1), 95-112, 2013 | 270 | 2013 |
| Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data HM Jones, HA Barton, Y Lai, Y Bi, E Kimoto, S Kempshall, SC Tate, ... Drug Metabolism and Disposition 40 (5), 1007-1017, 2012 | 263 | 2012 |
| Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver X Chu, K Korzekwa, R Elsby, K Fenner, A Galetin, Y Lai, P Matsson, ... Clinical Pharmacology & Therapeutics 94 (1), 126-141, 2013 | 252 | 2013 |
| Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs Y Lai, CM Tse, JD Unadkat Journal of Biological Chemistry 279 (6), 4490-4497, 2004 | 171 | 2004 |
| In situ hybridization and immunolocalization of concentrative and equilibrative nucleoside transporters in the human intestine, liver, kidneys, and placenta R Govindarajan, AH Bakken, KL Hudkins, Y Lai, FJ Casado, ... American Journal of Physiology-Regulatory, Integrative and Comparative …, 2007 | 165 | 2007 |
| Clinical probes and endogenous biomarkers as substrates for transporter drug‐drug interaction evaluation: perspectives from the international transporter consortium X Chu, M Liao, H Shen, K Yoshida, AA Zur, V Arya, A Galetin, ... Clinical Pharmacology & Therapeutics 104 (5), 836-864, 2018 | 159 | 2018 |
| LC–MS/MS-based quantification of clinically relevant intestinal uptake and efflux transporter proteins C Gröer, S Brück, Y Lai, A Paulick, A Busemann, CD Heidecke, ... Journal of pharmaceutical and biomedical analysis 85, 253-261, 2013 | 153 | 2013 |
| Coproporphyrins in plasma and urine can be appropriate clinical biomarkers to recapitulate drug-drug interactions mediated by organic anion transporting polypeptide inhibition Y Lai, S Mandlekar, H Shen, VK Holenarsipur, R Langish, P Rajanna, ... Journal of Pharmacology and Experimental Therapeutics 358 (3), 397-404, 2016 | 151 | 2016 |
| Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design L Di, C Keefer, DO Scott, TJ Strelevitz, G Chang, YA Bi, Y Lai, J Duckworth, ... European journal of medicinal chemistry 57, 441-448, 2012 | 146 | 2012 |
| Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions MVS Varma, Y Lai, B Feng, J Litchfield, TC Goosen, A Bergman Pharmaceutical research 29, 2860-2873, 2012 | 141 | 2012 |
| Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial … EW Lee, Y Lai, H Zhang, JD Unadkat Journal of Biological Chemistry 281 (24), 16700-16706, 2006 | 132 | 2006 |
| Hepatic uptake of atorvastatin: influence of variability in transporter expression on uptake clearance and drug-drug interactions A Vildhede, M Karlgren, EK Svedberg, JR Wisniewski, Y Lai, A Norén, ... Drug metabolism and disposition 42 (7), 1210-1218, 2014 | 126 | 2014 |
| Interindividual variability in the hepatic expression of the human breast cancer resistance protein (BCRP/ABCG2): effect of age, sex, and genotype B Prasad, Y Lai, Y Lin, JD Unadkat Journal of pharmaceutical sciences 102 (3), 787-793, 2013 | 122 | 2013 |
| Identification of interspecies difference in efflux transporters of hepatocytes from dog, rat, monkey and human M Li, H Yuan, N Li, G Song, Y Zheng, M Baratta, F Hua, A Thurston, ... European Journal of Pharmaceutical Sciences 35 (1-2), 114-126, 2008 | 119 | 2008 |
| Transporter expression in liver tissue from subjects with alcoholic or hepatitis C cirrhosis quantified by targeted quantitative proteomics L Wang, C Collins, EJ Kelly, X Chu, AS Ray, L Salphati, G Xiao, C Lee, ... Drug Metabolism and Disposition 44 (11), 1752-1758, 2016 | 115 | 2016 |
| Characterization of organic anion transporting polypeptide (OATP) expression and its functional contribution to the uptake of substrates in human hepatocytes E Kimoto, K Yoshida, LM Balogh, Y Bi, K Maeda, A El-Kattan, Y Sugiyama, ... Molecular pharmaceutics 9 (12), 3535-3542, 2012 | 115 | 2012 |
| A novel relay method for determining low-clearance values L Di, P Trapa, RS Obach, K Atkinson, YA Bi, AC Wolford, B Tan, ... Drug metabolism and disposition 40 (9), 1860-1865, 2012 | 112 | 2012 |
Jashvant UnadkatVerified email at uw.edu
