| Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion D Sareen, JG O’Rourke, P Meera, A Muhammad, S Grant, M Simpkinson, ... Science translational medicine 5 (208), 208ra149-208ra149, 2013 | 757 | 2013 |
| Genome-wide analyses identify KIF5A as a novel ALS gene A Nicolas, KP Kenna, AE Renton, N Ticozzi, F Faghri, R Chia, ... Neuron 97 (6), 1268-1283. e6, 2018 | 576 | 2018 |
| The library of integrated network-based cellular signatures NIH program: system-level cataloging of human cells response to perturbations AB Keenan, SL Jenkins, KM Jagodnik, S Koplev, E He, D Torre, Z Wang, ... Cell systems 6 (1), 13-24, 2018 | 390 | 2018 |
| Modeling ALS with motor neurons derived from human induced pluripotent stem cells S Sances, LI Bruijn, S Chandran, K Eggan, R Ho, JR Klim, MR Livesey, ... Nature neuroscience 19 (4), 542-553, 2016 | 299 | 2016 |
| Resveratrol inhibits tumor growth of human neuroblastoma and mediates apoptosis by directly targeting mitochondria PR Van Ginkel, D Sareen, L Subramanian, Q Walker, SR Darjatmoko, ... Clinical Cancer Research 13 (17), 5162-5169, 2007 | 222 | 2007 |
| Postmortem cortex samples identify distinct molecular subtypes of ALS: retrotransposon activation, oxidative stress, and activated glia OH Tam, NV Rozhkov, R Shaw, D Kim, I Hubbard, S Fennessey, N Propp, ... Cell reports 29 (5), 1164-1177. e5, 2019 | 217 | 2019 |
| Mitochondria, calcium, and calpain are key mediators of resveratrol-induced apoptosis in breast cancer D Sareen, SR Darjatmoko, DM Albert, AS Polans Molecular pharmacology 72 (6), 1466-1475, 2007 | 185 | 2007 |
| Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice Nature neuroscience 20 (5), 648-660, 2017 | 184 | 2017 |
| Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy D Sareen, AD Ebert, BM Heins, JV McGivern, L Ornelas, CN Svendsen PloS one 7 (6), e39113, 2012 | 171 | 2012 |
| miR-409-3p/-5p promotes tumorigenesis, epithelial-to-mesenchymal transition, and bone metastasis of human prostate cancer S Josson, M Gururajan, P Hu, C Shao, GCY Chu, HE Zhau, C Liu, K Lao, ... Clinical cancer research 20 (17), 4636-4646, 2014 | 147 | 2014 |
| Human iPSC-derived endothelial cells and microengineered organ-chip enhance neuronal development S Sances, R Ho, G Vatine, D West, A Laperle, A Meyer, M Godoy, PS Kay, ... Stem cell reports 10 (4), 1222-1236, 2018 | 146 | 2018 |
| Human induced pluripotent stem cells differentiate into functional mesenchymal stem cells and repair bone defects D Sheyn, S Ben-David, G Shapiro, S De Mel, M Bez, L Ornelas, ... Stem cells translational medicine 5 (11), 1447-1460, 2016 | 136 | 2016 |
| Mitochondria as the primary target of resveratrol-induced apoptosis in human retinoblastoma cells D Sareen, PR Van Ginkel, JC Takach, A Mohiuddin, SR Darjatmoko, ... Investigative ophthalmology & visual science 47 (9), 3708-3716, 2006 | 134 | 2006 |
| Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord D Sareen, G Gowing, A Sahabian, K Staggenborg, R Paradis, P Avalos, ... Journal of Comparative Neurology 522 (12), 2707-2728, 2014 | 126 | 2014 |
| EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs AD Ebert, BC Shelley, AM Hurley, M Onorati, V Castiglioni, TN Patitucci, ... Stem cell research 10 (3), 417-427, 2013 | 123 | 2013 |
| HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity VB Mattis, C Tom, S Akimov, J Saeedian, ME Østergaard, AL Southwell, ... Human molecular genetics 24 (11), 3257-3271, 2015 | 120 | 2015 |
| Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics M Candolfi, W Xiong, K Yagiz, C Liu, A Muhammad, M Puntel, D Foulad, ... Proceedings of the National Academy of Sciences 107 (46), 20021-20026, 2010 | 109 | 2010 |
| ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks R Ho, S Sances, G Gowing, MW Amoroso, JG O'Rourke, A Sahabian, ... Nature neuroscience 19 (9), 1256-1267, 2016 | 107 | 2016 |
| Chromosome 7 and 19 trisomy in cultured human neural progenitor cells D Sareen, E McMillan, AD Ebert, BC Shelley, JA Johnson, LF Meisner, ... PloS one 4 (10), e7630, 2009 | 101 | 2009 |
| G4C2 repeat RNA initiates a POM121-mediated reduction in specific nucleoporins in C9orf72 ALS/FTD AN Coyne, BL Zaepfel, L Hayes, B Fitchman, Y Salzberg, EC Luo, ... Neuron 107 (6), 1124-1140. e11, 2020 | 98 | 2020 |
