| Optimized arylomycins are a new class of Gram-negative antibiotics PA Smith, MFT Koehler, HS Girgis, D Yan, Y Chen, Y Chen, JJ Crawford, ... Nature 561 (7722), 189-194, 2018 | 314 | 2018 |
| Hippo pathway in cancer: aberrant regulation and therapeutic opportunities PC Calses, JJ Crawford, JR Lill, A Dey Trends in cancer 5 (5), 297-307, 2019 | 302 | 2019 |
| Discovery of GDC-0853: a potent, selective, and noncovalent Bruton’s tyrosine kinase inhibitor in early clinical development JJ Crawford, AR Johnson, DL Misner, LD Belmont, G Castanedo, R Choy, ... Journal of medicinal chemistry 61 (6), 2227-2245, 2018 | 218 | 2018 |
| Copper/TEMPO catalysed synthesis of nitriles from aldehydes or alcohols using aqueous ammonia and with air as the oxidant LM Dornan, Q Cao, JCA Flanagan, JJ Crawford, MJ Cook, MJ Muldoon Chemical communications 49 (54), 6030-6032, 2013 | 143 | 2013 |
| Battling Btk mutants with noncovalent inhibitors that overcome Cys481 and Thr474 mutations AR Johnson, PB Kohli, A Katewa, E Gogol, LD Belmont, R Choy, ... ACS chemical biology 11 (10), 2897-2907, 2016 | 140 | 2016 |
| Inhibitors of p21-activated kinases (PAKs) miniperspective J Rudolph, JJ Crawford, KP Hoeflich, W Wang Journal of medicinal chemistry 58 (1), 111-129, 2015 | 125 | 2015 |
| NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus HD Brightbill, E Suto, N Blaquiere, N Ramamoorthi, S Sujatha-Bhaskar, ... Nature communications 9 (1), 179, 2018 | 110 | 2018 |
| Diethylphosphine oxide (DEPO): high-yielding and facile preparation of indolones in water TA Khan, R Tripoli, JJ Crawford, CG Martin, JA Murphy Organic Letters 5 (16), 2971-2974, 2003 | 100 | 2003 |
| Small molecule dysregulation of TEAD lipidation induces a dominant-negative inhibition of hippo pathway signaling JK Holden, JJ Crawford, CL Noland, S Schmidt, JR Zbieg, JA Lacap, ... Cell reports 31 (12), 2020 | 89 | 2020 |
| RORγ antagonists and inverse agonists: a patent review SM Bronner, JR Zbieg, JJ Crawford Expert opinion on therapeutic patents 27 (1), 101-112, 2017 | 88 | 2017 |
| Recent progress on nuclear receptor RORγ modulators P Cyr, SM Bronner, JJ Crawford Bioorganic & medicinal chemistry letters 26 (18), 4387-4393, 2016 | 86 | 2016 |
| Total synthesis and stereochemistry of uncialamycin KC Nicolaou, H Zhang, JS Chen, JJ Crawford, L Pasunoori Angewandte Chemie International Edition 46 (25), 4704-4707, 2007 | 83 | 2007 |
| Streamlined total synthesis of uncialamycin and its application to the synthesis of designed analogues for biological investigations KC Nicolaou, Y Wang, M Lu, D Mandal, MR Pattanayak, R Yu, AA Shah, ... Journal of the American Chemical Society 138 (26), 8235-8246, 2016 | 82 | 2016 |
| Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pKa Polar Moiety CO Ndubaku, JJ Crawford, J Drobnick, I Aliagas, D Campbell, P Dong, ... ACS medicinal chemistry letters 6 (12), 1241-1246, 2015 | 81 | 2015 |
| Learning medicinal chemistry absorption, distribution, metabolism, excretion, and toxicity (ADMET) rules from cross-company matched molecular pairs analysis (MMPA) miniperspective C Kramer, A Ting, H Zheng, J Hert, T Schindler, M Stahl, G Robb, ... Journal of medicinal chemistry 61 (8), 3277-3292, 2017 | 76 | 2017 |
| A simple in vitro assay for assessing the reactivity of nitrile containing compounds PA MacFaul, AD Morley, JJ Crawford Bioorganic & Medicinal Chemistry Letters 19 (4), 1136-1138, 2009 | 76 | 2009 |
| Hippo pathway inhibition by blocking the YAP/TAZ–TEAD interface: a patent review JJ Crawford, SM Bronner, JR Zbieg Expert opinion on therapeutic patents 28 (12), 867-873, 2018 | 73 | 2018 |
| Chemically diverse group I p21-activated kinase (PAK) inhibitors impart acute cardiovascular toxicity with a narrow therapeutic window J Rudolph, LJ Murray, CO Ndubaku, T O’Brien, E Blackwood, W Wang, ... Journal of medicinal chemistry 59 (11), 5520-5541, 2016 | 64 | 2016 |
| Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell–associated damage in IFNα-driven lupus nephritis A Katewa, Y Wang, JA Hackney, T Huang, E Suto, N Ramamoorthi, ... JCI insight 2 (7), 2017 | 63 | 2017 |
| Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834 WB Young, J Barbosa, P Blomgren, MC Bremer, JJ Crawford, D Dambach, ... Bioorganic & Medicinal Chemistry Letters 25 (6), 1333-1337, 2015 | 61 | 2015 |
Daniel OrtwineConsultantVerified email at nestedtx.com
