|Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining|
KM Miller, JV Tjeertes, J Coates, G Legube, SE Polo, S Britton, ...
Nature structural & molecular biology 17 (99), 1144-1151, 2010
|Small-molecule–induced DNA damage identifies alternative DNA structures in human genes|
R Rodriguez, KM Miller, JV Forment, CR Bradshaw, M Nikan, S Britton, ...
Nature chemical biology 8 (3), 301-310, 2012
|A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair|
S Britton, J Coates, SP Jackson
J Cell Biol 202 (3), 579-595, 2013
|Chemical inhibition of NAT10 corrects defects of laminopathic cells|
D Larrieu, S Britton, M Demir, R Rodriguez, SP Jackson
Science 344 (6183), 527-532, 2014
|TRF2 and Apollo cooperate with topoisomerase 2α to protect human telomeres from replicative damage|
J Ye, C Lenain, S Bauwens, A Rizzo, A Saint-Léger, A Poulet, ...
Cell 142 (2), 230-242, 2010
|DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal|
S Britton, E Dernoncourt, C Delteil, C Froment, O Schiltz, B Salles, P Frit, ...
Nucleic acids research, gku601, 2014
|Neddylation promotes ubiquitylation and release of Ku from DNA-damage sites|
JS Brown, N Lukashchuk, M Sczaniecka-Clift, S Britton, C le Sage, ...
Cell reports 11 (5), 704-714, 2015
|Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks|
P Chanut, S Britton, J Coates, SP Jackson, P Calsou
Nature Communications 7, 2016
|ATR controls cellular adaptation to hypoxia through positive regulation of hypoxia-inducible factor 1 (HIF-1) expression|
F Fallone, S Britton, L Nieto, B Salles, C Muller
Oncogene 32 (37), 4387-4396, 2013
|Cell nonhomologous end joining capacity controls SAF-A phosphorylation by DNA-PK in response to DNA double-strand breaks inducers|
S Britton, C Froment, P Frit, B Monsarrat, B Salles, P Calsou
Cell Cycle 8 (22), 3717-3722, 2009
|ARTEMIS nuclease facilitates apoptotic chromatin cleavage|
S Britton, P Frit, D Biard, B Salles, P Calsou
Cancer research 69 (20), 8120-8126, 2009
|Biased and unbiased strategies to identify biologically active small molecules|
V Abet, A Mariani, FR Truscott, S Britton, R Rodriguez
Bioorganic & medicinal chemistry 22 (16), 4474-4489, 2014
|Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks|
A Cristini, G Ricci, S Britton, S Salimbeni, SN Huang, J Marinello, ...
Cell reports 28 (12), 3167-3181. e6, 2019
|c-MYC protein is degraded in response to UV irradiation|
S Britton, B Salles, P Calsou
Cell cycle 7 (1), 63-70, 2008
|A novel cytoprotective function for the DNA repair protein Ku in regulating p53 mRNA translation and function|
A Lamaa, M Le Bras, N Skuli, S Britton, P Frit, P Calsou, H Prats, ...
EMBO reports 17 (4), 508-518, 2016
|Phosphorylation of SAF-A/hnRNP-U serine 59 by Polo-like kinase 1 is required for mitosis|
P Douglas, R Ye, N Morrice, S Britton, L Trinkle-Mulcahy, SP Lees-Miller
Molecular and cellular biology 35 (15), 2699-2713, 2015
|Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein|
Y Yuan, S Britton, C Delteil, J Coates, SP Jackson, N Barboule, P Frit, ...
Nucleic acids research, gkv894, 2015
|Identification of three-way DNA junction ligands through screening of chemical libraries and validation by complementary in vitro assays|
K Duskova, J Lamarche, S Amor, C Caron, N Queyriaux, M Gaschard, ...
Journal of medicinal chemistry, 2019
|DNA junction ligands trigger DNA damage and are synthetic lethal with DNA repair inhibitors in cancer cells|
K Duskova, P Lejault, É Benchimol, R Guillot, S Britton, A Granzhan, ...
Journal of the American Chemical Society, 2019
|Biological relevance and therapeutic applications of DNA-and RNA-quadruplexes: double helix versus quadruple helix|
D Monchaud, S Britton, A Bartoli, R Rodriguez, P Šket, J Plavec, ...
Future Science Ltd, 2015