| Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes N Baker, L Glover, JC Munday, D Aguinaga Andrés, MP Barrett, ... Proceedings of the National Academy of Sciences 109 (27), 10996-11001, 2012 | 177 | 2012 |
| Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of … JC Munday, AA Eze, N Baker, L Glover, C Clucas, D Aguinaga Andrés, ... Journal of Antimicrobial Chemotherapy 69 (3), 651-663, 2014 | 138 | 2014 |
| Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei JC Munday, L Settimo, HP De Koning Frontiers in pharmacology 6, 32, 2015 | 76 | 2015 |
| Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA MK Gould, S Bachmaier, JAM Ali, S Alsford, DNA Tagoe, JC Munday, ... Antimicrobial agents and chemotherapy 57 (10), 4882-4893, 2013 | 66 | 2013 |
| Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake JC Munday, KER López, AA Eze, V Delespaux, J Van Den Abbeele, ... International Journal for Parasitology: Drugs and Drug Resistance 3, 69-76, 2013 | 62 | 2013 |
| The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes IA Teka, AJN Kazibwe, N El-Sabbagh, MI Al-Salabi, CP Ward, AA Eze, ... Molecular pharmacology 80 (1), 110-116, 2011 | 57 | 2011 |
| Oligopeptidase B deficient mutants of Leishmania major JC Munday, K McLuskey, E Brown, GH Coombs, JC Mottram Molecular and biochemical parasitology 175 (1), 49-57, 2011 | 54 | 2011 |
| Chimerization at the AQP2–AQP3 locus is the genetic basis of melarsoprol–pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates FE Graf, N Baker, JC Munday, HP De Koning, D Horn, P Mäser International Journal for Parasitology: Drugs and Drug Resistance 5 (2), 65-68, 2015 | 50 | 2015 |
| Functional analysis of drug resistance‐associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for … JC Munday, DNA Tagoe, AA Eze, JAM Krezdorn, KE Rojas López, ... Molecular microbiology 96 (4), 887-900, 2015 | 47 | 2015 |
| In vitro interactions between sitamaquine and amphotericin B, sodium stibogluconate, miltefosine, paromomycin and pentamidine against Leishmania donovani K Seifert, J Munday, T Syeda, SL Croft Journal of antimicrobial chemotherapy 66 (4), 850-854, 2011 | 43 | 2011 |
| Pyrimidine Biosynthesis Is Not an Essential Function for Trypanosoma brucei Bloodstream Forms JAM Ali, DNA Tagoe, JC Munday, A Donachie, LJ Morrison, ... Plos one 8 (3), e58034, 2013 | 42 | 2013 |
| Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal … AR Blaazer, AK Singh, E De Heuvel, E Edink, KM Orrling, JJN Veerman, ... Journal of medicinal chemistry 61 (9), 3870-3888, 2018 | 40 | 2018 |
| Reduced mitochondrial membrane potential Is a late adaptation of Trypanosoma brucei brucei to isometamidium preceded by mutations in the γ subunit of the F1Fo-ATPase AA Eze, MK Gould, JC Munday, DNA Tagoe, V Stelmanis, A Schnaufer, ... PLoS neglected tropical diseases 10 (8), e0004791, 2016 | 37 | 2016 |
| Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense FE Graf, P Ludin, C Arquint, RS Schmidt, N Schaub, C Kunz Renggli, ... Cellular and molecular life sciences 73, 3387-3400, 2016 | 29 | 2016 |
| Novel Minor Groove Binders cure animal African trypanosomiasis in an in vivo mouse model F Giordani, AI Khalaf, K Gillingwater, JC Munday, HP De Koning, ... Journal of medicinal chemistry 62 (6), 3021-3035, 2019 | 28 | 2019 |
| Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei AH Alghamdi, JC Munday, GD Campagnaro, D Gurvic, F Svensson, ... Elife 9, e56416, 2020 | 22 | 2020 |
| Cyclic nucleotide-specific phosphodiesterases as potential drug targets for anti-Leishmania therapy V Sebastián-Pérez, S Hendrickx, JC Munday, T Kalejaiye, A Martínez, ... Antimicrobial agents and chemotherapy 62 (10), 10.1128/aac. 00603-18, 2018 | 21 | 2018 |
| Diminazene resistance in Trypanosoma congolense is not caused by reduced transport capacity but associated with reduced mitochondrial membrane potential LV Carruthers, JC Munday, GU Ebiloma, P Steketee, S Jayaraman, ... Molecular Microbiology 116 (2), 564-588, 2021 | 15 | 2021 |
| Trypanosoma brucei bloodstream forms express highly specific and separate transporters for adenine and hypoxanthine; evidence for a new protozoan purine transporter family? GD Campagnaro, KJ Alzahrani, JC Munday, HP De Koning Molecular and biochemical parasitology 220, 46-56, 2018 | 15 | 2018 |
| Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity SS Botros, S William, ANA Sabra, NM El-Lakkany, SHS El-Din, ... International Journal for Parasitology: Drugs and Drug Resistance 9, 35-43, 2019 | 12 | 2019 |
