|Activation of innate immunity is required for efficient nuclear reprogramming|
J Lee, N Sayed, A Hunter, KF Au, WH Wong, ES Mocarski, RR Pera, ...
Cell 151 (3), 547-558, 2012
|NO and CO differentially activate soluble guanylyl cyclase via a heme pivot‐bend mechanism|
X Ma, N Sayed, A Beuve, F Van Den Akker
The EMBO journal 26 (2), 578-588, 2007
|Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation|
N Sayed, P Baskaran, X Ma, F Van Den Akker, A Beuve
Proceedings of the National Academy of Sciences 104 (30), 12312-12317, 2007
|High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells|
A Sharma, PW Burridge, WL McKeithan, R Serrano, P Shukla, N Sayed, ...
Science translational medicine 9 (377), 2017
|Translation of human-induced pluripotent stem cells: from clinical trial in a dish to precision medicine|
N Sayed, C Liu, JC Wu
Journal of the American College of Cardiology 67 (18), 2161-2176, 2016
|Nitroglycerin-induced S-nitrosylation and desensitization of soluble guanylyl cyclase contribute to nitrate tolerance|
N Sayed, DD Kim, X Fioramonti, T Iwahashi, WN Durán, A Beuve
Circulation research 103 (6), 606-614, 2008
|Transdifferentiation of human fibroblasts to endothelial cells: role of innate immunity|
N Sayed, WT Wong, F Ospino, S Meng, J Lee, A Jha, P Dexheimer, ...
Circulation 131 (3), 300-309, 2015
|Transcriptome profiling of patient-specific human iPSC-cardiomyocytes predicts individual drug safety and efficacy responses in vitro|
E Matsa, PW Burridge, KH Yu, JH Ahrens, V Termglinchan, H Wu, C Liu, ...
Cell stem cell 19 (3), 311-325, 2016
|PAS-mediated dimerization of soluble guanylyl cyclase revealed by signal transduction histidine kinase domain crystal structure|
X Ma, N Sayed, P Baskaran, A Beuve, F Van Den Akker
Journal of Biological Chemistry 283 (2), 1167-1178, 2008
|Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond|
C Liu, A Oikonomopoulos, N Sayed, JC Wu
Development 145 (5), 2018
|Determining the pathogenicity of a genomic variant of uncertain significance using CRISPR/Cas9 and human-induced pluripotent stem cells|
N Ma, JZ Zhang, I Itzhaki, SL Zhang, H Chen, F Haddad, T Kitani, ...
Circulation 138 (23), 2666-2681, 2018
|Large-scale single-cell RNA-seq reveals molecular signatures of heterogeneous populations of human induced pluripotent stem cell-derived endothelial cells|
DT Paik, L Tian, J Lee, N Sayed, IY Chen, S Rhee, JW Rhee, Y Kim, ...
Circulation research 123 (4), 443-450, 2018
|NaHS relaxes rat cerebral artery in vitro via inhibition of l-type voltage-sensitive Ca2+ channel|
XY Tian, WT Wong, N Sayed, J Luo, SY Tsang, ZX Bian, Y Lu, ...
Pharmacological research 65 (2), 239-246, 2012
|Endothelial cells derived from nuclear reprogramming|
WT Wong, NF Huang, CM Botham, N Sayed, JP Cooke
Circulation research 111 (10), 1363-1375, 2012
|Human-induced pluripotent stem cell model of trastuzumab-induced cardiac dysfunction in patients with breast cancer|
T Kitani, SG Ong, CK Lam, JW Rhee, JZ Zhang, A Oikonomopoulos, N Ma, ...
Circulation 139 (21), 2451-2465, 2019
|Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity|
Z Zhou, N Sayed, A Pyriochou, C Roussos, D Fulton, A Beuve, ...
Arteriosclerosis, thrombosis, and vascular biology 28 (10), 1803-1810, 2008
|Vascular aging: implications for cardiovascular disease and therapy|
YT Ghebre, E Yakubov, WT Wong, P Krishnamurthy, N Sayed, AG Sikora, ...
Translational medicine (Sunnyvale, Calif.) 6 (4), 2016
|A human iPSC double-reporter system enables purification of cardiac lineage subpopulations with distinct function and drug response profiles|
JZ Zhang, V Termglinchan, NY Shao, I Itzhaki, C Liu, N Ma, L Tian, ...
Cell Stem Cell 24 (5), 802-811. e5, 2019
|Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs|
MT Zhao, H Chen, Q Liu, NY Shao, N Sayed, HT Wo, JZ Zhang, SG Ong, ...
Proceedings of the National Academy of Sciences 114 (52), E11111-E11120, 2017
|Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?|
JP Stack, J Moslehi, N Sayed, JC Wu
European heart journal 40 (22), 1764-1770, 2019