| Insulin/IGF-1 drives PERIOD synthesis to entrain circadian rhythms with feeding time P Crosby, R Hamnett, M Putker, NP Hoyle, M Reed, CJ Karam, ... Cell 177 (4), 896-909. e20, 2019 | 270 | 2019 |
| Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate S Hameed P, S Solapure, V Patil, PP Henrich, PA Magistrado, S Bharath, ... Nature Communications 6 (1), 6715, 2015 | 68 | 2015 |
| Ligands for retinoic acid receptors are elevated in osteoarthritis and may contribute to pathologic processes in the osteoarthritic joint MR Davies, LR Ribeiro, M Downey‐Jones, MRC Needham, C Oakley, ... Arthritis & Rheumatism: Official Journal of the American College of …, 2009 | 41 | 2009 |
| A practical guide to secondary pharmacology in drug discovery S Jenkinson, F Schmidt, LR Ribeiro, A Delaunois, JP Valentin Journal of Pharmacological and Toxicological Methods 105, 106869, 2020 | 39 | 2020 |
| (1R,2R)-N-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly … AG Dossetter, H Beeley, J Bowyer, CR Cook, JJ Crawford, JE Finlayson, ... Journal of medicinal chemistry 55 (14), 6363-6374, 2012 | 37 | 2012 |
| In vitro secondary pharmacological profiling: An IQ-DruSafe industry survey on current practices JP Valentin, JM Guillon, S Jenkinson, V Kadambi, P Ravikumar, ... Journal of Pharmacological and Toxicological Methods 93, 7-14, 2018 | 27 | 2018 |
| Pharmacokinetic benefits of 3, 4-dimethoxy substitution of a phenyl ring and design of isosteres yielding orally available cathepsin K inhibitors JJ Crawford, PW Kenny, J Bowyer, CR Cook, JE Finlayson, C Heyes, ... Journal of Medicinal Chemistry 55 (20), 8827-8837, 2012 | 25 | 2012 |
| 5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors AD Morley, PW Kenny, B Burton, RA Heald, PA MacFaul, J Mullett, ... Bioorganic & medicinal chemistry letters 19 (6), 1658-1661, 2009 | 15 | 2009 |
| A semi-quantitative translational pharmacology analysis to understand the relationship between in vitro ENT1 inhibition and the clinical incidence of dyspnoea and bronchospasm LR Ribeiro, RI Storer Toxicology and Applied Pharmacology 317, 41-50, 2017 | 12 | 2017 |
| New associations between drug-induced adverse events in animal models and humans reveal novel candidate safety targets KA Giblin, D Basili, AM Afzal, L Rosenbrier-Ribeiro, N Greene, I Barrett, ... Chemical Research in Toxicology 34 (2), 438-451, 2020 | 10 | 2020 |
| Isosteric replacements for benzothiazoles and optimisation to potent Cathepsin K inhibitors free from hERG channel inhibition AG Dossetter, J Bowyer, CR Cook, JJ Crawford, JE Finlayson, NM Heron, ... Bioorganic & medicinal chemistry letters 22 (17), 5563-5568, 2012 | 5 | 2012 |
| New Trends in Pharmacological and Pharmaceutical Profiling LR Ribeiro, D Armstrong, T Jean, JP Valentin Drug Discovery and Development, Third Edition, 263-289, 2019 | 2 | 2019 |
| SARS-CoV-2 comprehensive receptor profiling: mechanistic insight to drive new therapeutic strategies SMV Brockbank, J Soden, R Faba-Rodriguez, LR Ribeiro, C Geh, ... BioRxiv, 2021.03. 11.434937, 2021 | 1 | 2021 |
| Acetylcholinesterase: Is there a recommended level of off target activity that can be tolerated and predicted safe? LR Ribeiro, M Morton, L Wright, S Kavanagh, M Rolf, D Armstrong, ... Journal of Pharmacological and Toxicological Methods 70 (3), 327, 2014 | 1 | 2014 |
| SARS-CoV-2 comprehensive receptor profiling: mechanistic insight to drive new therapeutic strategies (preprint) SMV Brockbank, R Faba-Rodriguez, LR Ribeiro, C Geh, H Thomas, ... | | 2021 |
| In vitro off-target profiling: impacting drug design and guiding quantitative translation risk assessments JP Valentin, D Armstrong, S Jenkinson, P Ravi, LR Ribeiro Toxicology Letters 295, S21, 2018 | | 2018 |
| Application of PBPK modelling of enterocyte exposure aids in vitro to in vivo translational risk assessment of μ-opioid-induced clinical constipation S Kavanagh, LR Ribeiro, T Noeske, P Sharma Toxicology Letters 295, S250, 2018 | | 2018 |
| Application of PBPK modelling of enterocyte exposure aids in vitro to in vivo translational risk assessment of μ-opioid-induced clinical constipation LR Ribeiro, P Sharma, S Kavanagh, T Noeske Journal of Pharmacological and Toxicological Methods 93, 151, 2018 | | 2018 |
| Evolution in diversity of a drugs primary target class poses a challenge to standard secondary pharmacology profiling: A look to future requirements and opportunities LR Ribeiro, C Larner, M Persson, C Scott Journal of Pharmacological and Toxicological Methods 93, 171-172, 2018 | | 2018 |
| Interpreting In Vitro Pharmacological Profiling Data Requires Contextualisation of Risk in Relation to the Safety Margin for Different Off-target Interactions: Translational … LR Ribeiro, M Pietras Journal of Pharmacological and Toxicological Methods 88, 215, 2017 | | 2017 |
