Paolo Arosio
Paolo Arosio
Assistant Professor, ETH Zurich
Email verificata su - Home page
Citata da
Citata da
On the lag phase in amyloid fibril formation
P Arosio, TPJ Knowles, S Linse
Physical Chemistry Chemical Physics 17, 7606-7618, 2015
Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology
G Wei, Z Su, NP Reynolds, P Arosio, IW Hamley, E Gazit, R Mezzenga
Chemical Society Reviews 46 (15), 4661-4708, 2017
Molecular mechanisms of protein aggregation from global fitting of kinetic models.
G Meisl, JB Kirkegaard, P Arosio, TCT Michaels, M Vendruscolo, ...
Nature Protocols 11 (2), 252-272, 2016
A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers
SIA Cohen, P Arosio, J Presto, F Kurudenkandy, H Roshan Biverstal, ...
Nature structural & molecular biology 22 (3), 207-213, 2015
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation
N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, ...
Journal of the American Chemical Society 136 (10), 3859-3868, 2014
Chemical kinetics for drug discovery to combat protein aggregation diseases
P Arosio, M Vendruscolo, CM Dobson, TPJ Knowles
Trends in pharmacological sciences 35 (3), 127-135, 2014
Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation
P Arosio, TCT Michaels, S Linse, C Mnsson, C Emanuelsson, J Presto, ...
Nature communications 7 (1), 1-9, 2016
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease
J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, ...
Proceedings of the National Academy of Sciences 114 (2), E200-E208, 2017
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, ...
Science advances 2 (2), e1501244, 2016
The S/T-rich motif in the DNAJB6 chaperone delays polyglutamine aggregation and the onset of disease in a mouse model
V Kakkar, C Mnsson, EP de Mattos, S Bergink, M van der Zwaag, ...
Molecular cell 62 (2), 272-283, 2016
Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
TCT Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, AJ Dear, ...
Nature chemistry 12 (5), 445-451, 2020
Quantification of the concentration of Aβ42 propagons during the lag phase by an amyloid chain reaction assay
P Arosio, R Cukalevski, B Frohm, TPJ Knowles, S Linse
Journal of the American Chemical Society 136 (1), 219-225, 2014
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, ...
Science advances 3 (6), e1700488, 2017
Aggregation mechanism of an IgG2 and two IgG1 monoclonal antibodies at low pH: from oligomers to larger aggregates
P Arosio, S Rima, M Morbidelli
Pharmaceutical research 30 (3), 641-654, 2013
Secondary nucleation and elongation occur at different sites on Alzheimer’s amyloid-β aggregates
T Scheidt, U Łapińska, JR Kumita, DR Whiten, D Klenerman, MR Wilson, ...
Science Advances 5 (4), eaau3112, 2019
Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation
C Mnsson, P Arosio, R Hussein, HH Kampinga, RM Hashem, ...
Journal of Biological Chemistry 289 (45), 31066-31076, 2014
Aggregation stability of a monoclonal antibody during downstream processing
P Arosio, G Barolo, T Mller-Spth, H Wu, M Morbidelli
Pharmaceutical research 28 (8), 1884-1894, 2011
Microfluidic diffusion analysis of the sizes and interactions of proteins under native solution conditions
P Arosio, T Mueller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, ...
ACS Nano 10, 333-341, 2016
Structural ensembles of membrane-bound α-synuclein reveal the molecular determinants of synaptic vesicle affinity
G Fusco, A De Simone, P Arosio, M Vendruscolo, G Veglia, CM Dobson
Scientific reports 6 (1), 1-9, 2016
Population balance modeling of antibodies aggregation kinetics
P Arosio, S Rima, M Lattuada, M Morbidelli
The Journal of Physical Chemistry B 116 (24), 7066-7075, 2012
Il sistema al momento non pu eseguire l'operazione. Riprova pi tardi.
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