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Peter W Kenny
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Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure
AG Leach, HD Jones, DA Cosgrove, PW Kenny, L Ruston, P MacFaul, ...
Journal of medicinal chemistry 49 (23), 6672-6682, 2006
2942006
Structure modification in chemical databases
PW Kenny, J Sadowski
Chemoinformatics in drug discovery, 271-285, 2005
2372005
Identification of compounds with nanomolar binding affinity for checkpoint kinase-1 using knowledge-based virtual screening
PD Lyne, PW Kenny, DA Cosgrove, C Deng, S Zabludoff, JJ Wendoloski, ...
Journal of medicinal chemistry 47 (8), 1962-1968, 2004
1662004
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, ...
Cell Stem Cell 29 (2), 217-231. e8, 2022
1652022
Hydrogen bonding, electrostatic potential, and molecular design
PW Kenny
Journal of chemical information and modeling 49 (5), 1234-1244, 2009
1562009
An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes
JS Albert, N Blomberg, AL Breeze, AJH Brown, JN Burrows, PD Edwards, ...
Current Topics in Medicinal Chemistry 7 (16), 1600-1629, 2007
1482007
Pharmacophoric pattern matching in files of three-dimensional chemical structures: Comparison of conformational-searching algorithms for flexible searching
DE Clark, G Jones, P Willett, PW Kenny, RC Glen
Journal of Chemical Information and Computer Sciences 34 (1), 197-206, 1994
1361994
Structure-based design of protein tyrosine phosphatase-1B inhibitors
E Black, J Breed, AL Breeze, K Embrey, R Garcia, TW Gero, L Godfrey, ...
Bioorganic & medicinal chemistry letters 15 (10), 2503-2507, 2005
1072005
Design of compound libraries for fragment screening
N Blomberg, DA Cosgrove, PW Kenny, K Kolmodin
Journal of computer-aided molecular design 23, 513-525, 2009
902009
Inflation of correlation in the pursuit of drug-likeness
PW Kenny, CA Montanari
Journal of computer-aided molecular design 27, 1-13, 2013
882013
Molecular design, synthesis and trypanocidal activity of dipeptidyl nitriles as cruzain inhibitors
LAA Avelar, CD Camilo, S de Albuquerque, WB Fernandes, C Gonçalez, ...
PLOS Neglected Tropical Diseases 9 (7), e0003916, 2015
812015
The nature of ligand efficiency
PW Kenny
Journal of Cheminformatics 11, 1-18, 2019
762019
Prediction of hydrogen bond basicity from computed molecular electrostatic properties: implications for comparative molecular field analysis
PW Kenny
Journal of the Chemical Society, Perkin Transactions 2, 199-202, 1994
751994
New nonpeptide angiotensin II receptor antagonists. 3. Synthesis, biological properties, and structure-activity relationships of 2-alkyl-4-(biphenylylmethoxy) pyridine derivatives
RH Bradbury, CP Allott, M Dennis, JA Girdwood, PW Kenny, JS Major, ...
Journal of medicinal chemistry 36 (9), 1245-1254, 1993
731993
Ligand efficiency metrics considered harmful
PW Kenny, A Leitao, CA Montanari
Journal of computer-aided molecular design 28, 699-710, 2014
652014
Dipeptidyl nitrile inhibitors of Cathepsin L
N Asaad, PA Bethel, MD Coulson, JE Dawson, SJ Ford, S Gerhardt, ...
Bioorganic & Medicinal Chemistry Letters 19 (15), 4280-4283, 2009
622009
Pharmacophoric pattern matching in files of three-dimensional chemical structures: use of bounded distance matrices for the representation and searching of conformationally …
DE Clark, P Willett, PW Kenny
Journal of molecular graphics 10 (4), 194-204, 1992
551992
COVID moonshot: open science discovery of SARS-CoV-2 main protease inhibitors by combining crowdsourcing, high-throughput experiments, computational simulations, and machine …
H Achdout, A Aimon, E Bar-David, GM Morris
BioRxiv, 2020
532020
Discovery of novel imidazo [1, 2-a] pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase
R Ducray, I Simpson, FH Jung, JWM Nissink, PW Kenny, M Fitzek, ...
Bioorganic & medicinal chemistry letters 21 (16), 4698-4701, 2011
522011
Toward prediction of alkane/water partition coefficients
A Toulmin, JM Wood, PW Kenny
Journal of medicinal chemistry 51 (13), 3720-3730, 2008
522008
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Articles 1–20