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Sylvie Lesage
Sylvie Lesage
Professor of Immunology, Université de Montréal
Adresse e-mail validée de umontreal.ca
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Aire regulates negative selection of organ-specific T cells
A Liston, S Lesage, J Wilson, L Peltonen, CC Goodnow
Nature immunology 4 (4), 350-354, 2003
9822003
Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells
A Philips, S Lesage, R Gingras, MH Maira, Y Gauthier, P Hugo, J Drouin
Molecular and cellular biology, 1997
4311997
Gene Dosage–limiting Role of Aire in Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity
A Liston, DHD Gray, S Lesage, AL Fletcher, J Wilson, KE Webster, ...
The Journal of experimental medicine 200 (8), 1015-1026, 2004
3482004
Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis
JE Jun, LE Wilson, CG Vinuesa, S Lesage, M Blery, LA Miosge, MC Cook, ...
Immunity 18 (6), 751-762, 2003
3372003
The importance of dendritic cells in maintaining immune tolerance
C Audiger, MJ Rahman, TJ Yun, KV Tarbell, S Lesage
The Journal of Immunology 198 (6), 2223-2231, 2017
2802017
Antagonism between Nur77 and glucocorticoid receptor for control of transcription
A Philips, M Maira, A Mullick, M Chamberland, S Lesage, P Hugo, ...
Molecular and cellular biology 17 (10), 5952-5959, 1997
2541997
Generalized resistance to thymic deletion in the NOD mouse: a polygenic trait characterized by defective induction of Bim
A Liston, S Lesage, DHD Gray, LA O'Reilly, A Strasser, AM Fahrer, ...
Immunity 21 (6), 817-830, 2004
2072004
Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes
S Lesage, SB Hartley, S Akkaraju, J Wilson, M Townsend, CC Goodnow
The Journal of experimental medicine 196 (9), 1175-1188, 2002
1812002
Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes
J Dooley, L Tian, S Schonefeldt, V Delghingaro-Augusto, JE Garcia-Perez, ...
Nature genetics 48 (5), 519-527, 2016
1402016
Expression of the self‐marker CD47 on dendritic cells governs their trafficking to secondary lymphoid organs
VQ Van, S Lesage, S Bouguermouh, P Gautier, M Rubio, M Levesque, ...
The EMBO journal 25 (23), 5560-5568, 2006
1092006
Specific activation of the cysteine protease CPP32 during the negative selection of T cells in the thymus
A Alam, MY Braun, F Hartgers, S Lesage, L Cohen, P Hugo, F Denis, ...
The Journal of experimental medicine 186 (9), 1503-1512, 1997
1091997
CD4+ CD8+ thymocytes are preferentially induced to die following CD45 cross-linking, through a novel apoptotic pathway.
S Lesage, AM Steff, F Philippoussis, M Pagé, S Trop, V Mateo, P Hugo
Journal of immunology (Baltimore, Md.: 1950) 159 (10), 4762-4771, 1997
1051997
A comprehensive review of the phenotype and function of antigen-specific immunoregulatory double negative T cells
EE Hillhouse, S Lesage
Journal of autoimmunity 40, 58-65, 2013
1002013
IL23R (interleukin 23 receptor) variants protective against inflammatory bowel diseases (IBD) display loss of function due to impaired protein stability and intracellular …
D Sivanesan, C Beauchamp, C Quinou, J Lee, S Lesage, S Chemtob, ...
Journal of Biological Chemistry 291 (16), 8673-8685, 2016
892016
Genetic lesions in T‐cell tolerance and thresholds for autoimmunity
A Liston, S Lesage, DHD Gray, RL Boyd, CC Goodnow
Immunological reviews 204 (1), 87-101, 2005
802005
T cell tolerance to a neo-self antigen expressed by thymic epithelial cells: the soluble form is more effective than the membrane-bound form
M Zhang, MS Vacchio, BP Vistica, S Lesage, CE Egwuagu, CR Yu, ...
The Journal of Immunology 170 (8), 3954-3962, 2003
652003
Interleukin‐10 limits the expansion of immunoregulatory CD4CD8 T cells in autoimmune‐prone non‐obese diabetic mice
EE Hillhouse, C Beauchamp, G Chabot‐Roy, V Dugas, S Lesage
Immunology and cell biology 88 (8), 771-780, 2010
602010
The orphan nuclear receptor NR4A3 controls the differentiation of monocyte-derived dendritic cells following microbial stimulation
S Boulet, JF Daudelin, L Odagiu, AN Pelletier, TJ Yun, S Lesage, ...
Proceedings of the National Academy of Sciences 116 (30), 15150-15159, 2019
582019
Implication of the CD47 pathway in autoimmune diabetes
V Dugas, C Beauchamp, G Chabot-Roy, EE Hillhouse, S Lesage
Journal of autoimmunity 35 (1), 23-32, 2010
562010
LILAC pilot study: effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy
D Planas, A Pagliuzza, R Ponte, A Fert, LR Marchand, M Massanella, ...
EBioMedicine 65, 2021
502021
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