| Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins DJ Schaer, PW Buehler, AI Alayash, JD Belcher, GM Vercellotti Blood, The Journal of the American Society of Hematology 121 (8), 1276-1284, 2013 | 749 | 2013 |
| Systemic and mucosal antibody responses specific to SARS-CoV-2 during mild versus severe COVID-19 C Cervia, J Nilsson, Y Zurbuchen, A Valaperti, J Schreiner, ... Journal of Allergy and Clinical Immunology 147 (2), 545-557. e9, 2021 | 415 | 2021 |
| Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes P Linscheid, D Seboek, DJ Schaer, H Zulewski, U Keller, B Müller Critical care medicine 32 (8), 1715-1721, 2004 | 403 | 2004 |
| Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10 C Pereira, DJ Schaer, EB Bachli, MO Kurrer, G Schoedon Arteriosclerosis, thrombosis, and vascular biology 28 (3), 504-510, 2008 | 380 | 2008 |
| Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin CA Schaer, G Schoedon, A Imhof, MO Kurrer, DJ Schaer Circulation research 99 (9), 943-950, 2006 | 321 | 2006 |
| CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin DJ Schaer, CA Schaer, PW Buehler, RA Boykins, G Schoedon, AI Alayash, ... Blood 107 (1), 373-380, 2006 | 321 | 2006 |
| Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy JH Baek, F D’Agnillo, F Vallelian, CP Pereira, MC Williams, Y Jia, ... The Journal of clinical investigation 122 (4), 1444-1458, 2012 | 301 | 2012 |
| Haptoglobin, hemopexin, and related defense pathways—basic science, clinical perspectives, and drug development DJ Schaer, F Vinchi, G Ingoglia, E Tolosano, PW Buehler Frontiers in physiology 5, 107819, 2014 | 282 | 2014 |
| Haemophagocytic syndromes in adults: current concepts and challenges ahead U Emmenegger, DJ Schaer, C Larroche, KA Neftel Swiss medical weekly 135 (2122), 299-314, 2005 | 268 | 2005 |
| Soluble hemoglobin–haptoglobin scavenger receptor CD163 as a lineage‐specific marker in the reactive hemophagocytic syndrome DJ Schaer, B Schleiffenbaum, M Kurrer, A Imhof, E Bächli, J Fehr, ... European journal of haematology 74 (1), 6-10, 2005 | 239 | 2005 |
| Activating transcription factor 1 directs Mhem atheroprotective macrophages through coordinated iron handling and foam cell protection JJ Boyle, M Johns, T Kampfer, AT Nguyen, L Game, DJ Schaer, JC Mason, ... Circulation research 110 (1), 20-33, 2012 | 219 | 2012 |
| Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification PW Buehler, B Abraham, F Vallelian, C Linnemayr, CP Pereira, JF Cipollo, ... Blood, The Journal of the American Society of Hematology 113 (11), 2578-2586, 2009 | 218 | 2009 |
| Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs FS Boretti, PW Buehler, F D’Agnillo, K Kluge, T Glaus, OI Butt, Y Jia, ... The Journal of clinical investigation 119 (8), 2271-2280, 2009 | 214 | 2009 |
| Neurological adverse events to voriconazole: evidence for therapeutic drug monitoring A Imhof, DJ Schaer, U Schwarz, U Schanz Swiss medical weekly 136 (4546), 739-742, 2006 | 182 | 2006 |
| Induction of the CD163‐dependent haemoglobin uptake by macrophages as a novel anti‐inflammatory action of glucocorticoids DJ Schaer, FS Boretti, G Schoedon, A Schaffner British journal of haematology 119 (1), 239-243, 2002 | 180 | 2002 |
| Hemoglobin-based oxygen carriers: from mechanisms of toxicity and clearance to rational drug design PW Buehler, F D’Agnillo, DJ Schaer Trends in molecular medicine 16 (10), 447-457, 2010 | 161 | 2010 |
| A distinct innate immune signature marks progression from mild to severe COVID-19 S Chevrier, Y Zurbuchen, C Cervia, S Adamo, ME Raeber, N de Souza, ... Cell Reports Medicine 2 (1), 2021 | 133 | 2021 |
| Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis DJ Schaer, CA Schaer, G Schoedon, A Imhof, MO Kurrer European journal of haematology 77 (5), 432-436, 2006 | 125 | 2006 |
| Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response JW Deuel, CA Schaer, FS Boretti, L Opitz, I García-Rubio, JH Baek, ... Cell death & disease 7 (1), e2064-e2064, 2016 | 122 | 2016 |
| Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145 CE Cooper, DJ Schaer, PW Buehler, MT Wilson, BJ Reeder, G Silkstone, ... Antioxidants & redox signaling 18 (17), 2264-2273, 2013 | 117 | 2013 |
