Laura M. Bohn, PhD
Laura M. Bohn, PhD
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Enhanced morphine analgesia in mice lacking β-arrestin 2
LM Bohn, RJ Lefkowitz, RR Gainetdinov, K Peppel, MG Caron, FT Lin
Science 286 (5449), 2495-2498, 1999
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
LM Bohn, RR Gainetdinov, FT Lin, RJ Lefkowitz, MG Caron
Nature 408 (6813), 720-723, 2000
Desensitization of G protein–coupled receptors and neuronal functions
RR Gainetdinov, RT Premont, LM Bohn, RJ Lefkowitz, MG Caron
Annu. Rev. Neurosci. 27, 107-144, 2004
Mice lacking the norepinephrine transporter are supersensitive to psychostimulants
F Xu, RR Gainetdinov, WC Wetsel, SR Jones, LM Bohn, GW Miller, ...
Nature neuroscience 3 (5), 465-471, 2000
Morphine side effects in β-arrestin 2 knockout mice
KM Raehal, JKL Walker, LM Bohn
Journal of Pharmacology and Experimental Therapeutics 314 (3), 1195-1201, 2005
Crystal structure of the human cannabinoid receptor CB1
T Hua, K Vemuri, M Pu, L Qu, GW Han, Y Wu, S Zhao, W Shui, S Li, ...
Cell 167 (3), 750-762. e14, 2016
Differential mechanisms of morphine antinociceptive tolerance revealed in βarrestin-2 knock-out mice
LM Bohn, RJ Lefkowitz, MG Caron
Journal of Neuroscience 22 (23), 10494-10500, 2002
Crystal structures of agonist-bound human cannabinoid receptor CB1
T Hua, K Vemuri, SP Nikas, RB Laprairie, Y Wu, L Qu, M Pu, A Korde, ...
Nature 547 (7664), 468-471, 2017
Bias factor and therapeutic window correlate to predict safer opioid analgesics
CL Schmid, NM Kennedy, NC Ross, KM Lovell, Z Yue, J Morgenweck, ...
Cell 171 (5), 1165-1175. e13, 2017
An opioid agonist that does not induce μ-opioid receptor—arrestin interactions or receptor internalization
CE Groer, K Tidgewell, RA Moyer, WW Harding, RB Rothman, ...
Molecular pharmacology 71 (2), 549-557, 2007
Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice
RR Gainetdinov, LM Bohn, TD Sotnikova, M Cyr, A Laakso, AD Macrae, ...
Neuron 38 (2), 291-303, 2003
Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance
KM Raehal, CL Schmid, CE Groer, LM Bohn
Pharmacological reviews 63 (4), 1001-1019, 2011
Muscarinic supersensitivity and impaired receptor desensitization in G protein–coupled receptor kinase 5–deficient mice
RR Gainetdinov, LM Bohn, JKL Walker, SA Laporte, AD Macrae, ...
Neuron 24 (4), 1029-1036, 1999
Opioid receptor homo-and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer
D Wang, X Sun, LM Bohn, W Sadee
Molecular pharmacology 67 (6), 2173-2184, 2005
Enhanced rewarding properties of morphine, but not cocaine, in βarrestin-2 knock-out mice
LM Bohn, RR Gainetdinov, TD Sotnikova, IO Medvedev, RJ Lefkowitz, ...
Journal of Neuroscience 23 (32), 10265-10273, 2003
Biased agonism: An emerging paradigm in GPCR drug discovery
Z Rankovic, TF Brust, LM Bohn
Bioorganic & medicinal chemistry letters 26 (2), 241-250, 2016
Agonist-directed signaling of the serotonin 2A receptor depends on β-arrestin-2 interactions in vivo
CL Schmid, KM Raehal, LM Bohn
Proceedings of the National Academy of Sciences 105 (3), 1079-1084, 2008
Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery
LM Bohn, LA Dykstra, RJ Lefkowitz, MG Caron, LS Barak
Molecular pharmacology 66 (1), 106-112, 2004
Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter
RR Gainetdinov, AR Mohn, LM Bohn, MG Caron
Proceedings of the National Academy of Sciences 98 (20), 11047-11054, 2001
The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics
KM Raehal, LM Bohn
Neuropharmacology 60 (1), 58-65, 2011
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