| Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators AC Kruegel, MM Gassaway, A Kapoor, A Váradi, S Majumdar, M Filizola, ... Journal of the American Chemical Society 138 (21), 6754-6764, 2016 | 295 | 2016 |
| Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM TET Hughes, DT Lodowski, KW Huynh, A Yazici, J Del Rosario, A Kapoor, ... Nature structural & molecular biology 25 (1), 53-60, 2018 | 117 | 2018 |
| Clinical development times for innovative drugs DG Brown, HJ Wobst, A Kapoor, LA Kenna, N Southall Nat. Rev. Drug Discov 21 (11), 793-794, 2021 | 90 | 2021 |
| Molecular mechanism of setron-mediated inhibition of full-length 5-HT3A receptor S Basak, Y Gicheru, A Kapoor, ML Mayer, M Filizola, S Chakrapani Nature communications 10 (1), 3225, 2019 | 50 | 2019 |
| Structural insight of dopamine β-hydroxylase, a drug target for complex traits, and functional significance of exonic single nucleotide polymorphisms A Kapoor, M Shandilya, S Kundu PloS one 6 (10), e26509, 2011 | 47 | 2011 |
| Structure-based characterization of novel TRPV5 inhibitors TET Hughes, JS Del Rosario, A Kapoor, AT Yazici, Y Yudin, EC Fluck III, ... Elife 8, e49572, 2019 | 45 | 2019 |
| Dynamic and Kinetic Elements of µ-Opioid Receptor Functional Selectivity A Kapoor, G Martinez-Rosell, D Provasi, G de Fabritiis, M Filizola Scientific Reports, 2017 | 43 | 2017 |
| Differential dynamics of RAS isoforms in GDP‐and GTP‐bound states A Kapoor, A Travesset Proteins: Structure, Function, and Bioinformatics 83 (6), 1091-1106, 2015 | 43 | 2015 |
| High-resolution structures of multiple 5-HT3AR-setron complexes reveal a novel mechanism of competitive inhibition S Basak, A Kumar, S Ramsey, E Gibbs, A Kapoor, M Filizola, ... Elife 9, e57870, 2020 | 35 | 2020 |
| Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake JH Wardman, I Gomes, EN Bobeck, JA Stockert, A Kapoor, P Bisignano, ... Science Signaling 9 (430), ra55-ra55, 2016 | 33 | 2016 |
| Predicted Mode of Binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom’s Alkaloids with Reported Antinociception In Vivo Y Zhou, S Ramsey, D Provasi, A El Daibani, K Appourchaux, ... Biochemistry 60 (18), 1420-1429, 2020 | 27 | 2020 |
| A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects KD Pryce, HJ Kang, F Sakloth, Y Liu, S Khan, K Toth, A Kapoor, A Nicolais, ... Neuropharmacology 195, 108673, 2021 | 18 | 2021 |
| Atomic-level characterization of the methadone-stabilized active conformation of µ-opioid receptor A Kapoor, D Provasi, M Filizola Molecular Pharmacology 98 (4), 475-486, 2020 | 17 | 2020 |
| Folding and stability of helical bundle proteins from coarse-grained models A Kapoor, A Travesset Biophysical Journal 104 (2), 225a, 2013 | 13 | 2013 |
| Structural and Functional Significance of the N- and C-Terminal Appendages in Arabidopsis Truncated Hemoglobin N Mukhi, S Dhindwal, S Uppal, A Kapoor, R Arya, P Kumar, J Kaur, ... Biochemistry 55 (12), 1724-1740, 2016 | 12 | 2016 |
| Mechanism of the exchange reaction in HRAS from multiscale modeling A Kapoor, A Travesset PloS one 9 (10), e108846, 2014 | 11 | 2014 |
| High-throughput cellular thermal shift assay using acoustic transfer of protein lysates AE Owens, MJ Iannotti, TW Sanchez, T Voss, A Kapoor, MD Hall, ... ACS chemical biology 17 (2), 322-330, 2022 | 10 | 2022 |
| SOX11 inhibitors are cytotoxic in mantle cell lymphoma SS Jatiani, S Christie, VV Leshchenko, R Jain, A Kapoor, P Bisignano, ... Clinical Cancer Research 27 (16), 4652-4663, 2021 | 9 | 2021 |
| Folding 19 proteins to their native state and stability of large proteins from a coarse‐grained model A Kapoor, A Travesset Proteins: Structure, Function, and Bioinformatics 82 (3), 505-516, 2014 | 6 | 2014 |
| Phe28B10 Induces Channel-Forming Cytotoxic Amyloid Fibrillation in Human Neuroglobin, the Brain-Specific Hemoglobin S Uppal, AK Singh, R Arya, D Tewari, N Jaiswal, A Kapoor, AK Bera, ... Biochemistry 55 (49), 6832-6847, 2016 | 3 | 2016 |
Marta FilizolaDean and Professor at Icahn School of Medicine at Mount SinaiVerified email at mssm.edu
