Hongtao Zhao
Hongtao Zhao
Unknown affiliation
Verified email at lephar.com - Homepage
Cited by
Cited by
PARP1 ADP-ribosylates lysine residues of the core histone tails
S Messner, M Altmeyer, H Zhao, A Pozivil, B Roschitzki, P Gehrig, ...
Nucleic acids research 38 (19), 6350-6362, 2010
Multilayer membranes for glucose biosensing via layer-by-layer assembly of multiwall carbon nanotubes and glucose oxidase
H Zhao, H Ju
Analytical biochemistry 350 (1), 138-144, 2006
Electrodeposition of silver–DNA hybrid nanoparticles for electrochemical sensing of hydrogen peroxide and glucose
S Wu, H Zhao, H Ju, C Shi, J Zhao
Electrochemistry Communications 8 (8), 1197-1203, 2006
Molecular dynamics in drug design
H Zhao, A Caflisch
European journal of medicinal chemistry 91, 4-14, 2015
Discovery of BRD4 bromodomain inhibitors by fragment-based high-throughput docking
H Zhao, L Gartenmann, J Dong, D Spiliotopoulos, A Caflisch
Bioorganic & medicinal chemistry letters 24 (11), 2493-2496, 2014
Discovery of ZAP70 inhibitors by high-throughput docking into a conformation of its kinase domain generated by molecular dynamics
H Zhao, A Caflisch
Bioorganic & medicinal chemistry letters 23 (20), 5721-5726, 2013
Hydrogen bonding penalty upon ligand binding
H Zhao, D Huang
PloS one 6 (6), e19923, 2011
Electrochemical biosensors for DNA analysis
H Ju, H Zhao
Frontiers in Bioscience 10 (1), 37-46, 2005
Discovery of tyrosine kinase inhibitors by docking into an inactive kinase conformation generated by molecular dynamics
H Zhao, D Huang, A Caflisch
ChemMedChem 7 (11), 1983-1990, 2012
Discovery of a novel chemotype of tyrosine kinase inhibitors by fragment-based docking and molecular dynamics
H Zhao, J Dong, K Lafleur, C Nevado, A Caflisch
ACS Medicinal Chemistry Letters 3 (10), 834-838, 2012
Enriching screening libraries with bioactive fragment space
N Zhang, H Zhao
Bioorganic & medicinal chemistry letters 26 (15), 3594-3597, 2016
The “Gatekeeper” residue influences the mode of binding of acetyl indoles to bromodomains
A Unzue, H Zhao, G Lolli, J Dong, J Zhu, M Zechner, A Dolbois, A Caflisch, ...
Journal of Medicinal Chemistry 59 (7), 3087-3097, 2016
Pyrrolo[3,2-b]quinoxaline Derivatives as Types I1/2 and II Eph Tyrosine Kinase Inhibitors: Structure-Based Design, Synthesis, and in Vivo Validation
A Unzue, J Dong, K Lafleur, H Zhao, E Frugier, A Caflisch, C Nevado
Journal of medicinal chemistry 57 (15), 6834-6844, 2014
Discovery of dual ZAP70 and Syk kinases inhibitors by docking into a rare C-helix-out conformation of Syk
H Zhao, A Caflisch
Bioorganic & medicinal chemistry letters 24 (6), 1523-1527, 2014
Three stories on Eph kinase inhibitors: From in silico discovery to in vivo validation
A Unzue, K Lafleur, H Zhao, T Zhou, J Dong, P Kolb, J Liebl, S Zahler, ...
European journal of medicinal chemistry 112, 347-366, 2016
Current kinase inhibitors cover a tiny fraction of fragment space
H Zhao, A Caflisch
Bioorganic & Medicinal Chemistry Letters 25 (11), 2372-2376, 2015
Biosensor for Hepatitis B Virus DNA PCR Product and Electrochemical Study of the Interaction of Di (2, 2′‐bipyridine) osmium (III) with DNA
H Zhao, H Ju
Electroanalysis: An International Journal Devoted to Fundamental and …, 2004
Structural Analysis of the Binding of Type I, I1/2, and II Inhibitors to Eph Tyrosine Kinases
J Dong, H Zhao, T Zhou, D Spiliotopoulos, C Rajendran, XD Li, D Huang, ...
ACS medicinal chemistry letters 6 (1), 79-83, 2015
Identification and regulation of the catalytic promiscuity of (−)-γ-lactamase from Microbacterium hydrocarbonoxydans
Y Sun, H Zhao, J Wang, J Zhu, S Wu
Applied microbiology and biotechnology 99 (18), 7559-7568, 2015
Rational design of coumarin derivatives as CK2 inhibitors by improving the interaction with the hinge region
N Zhang, W Chen, Y Zhou, H Zhao, R Zhong
Molecular informatics 35 (1), 15-18, 2016
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