| Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 13447* | 2021 |
| Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes ARJ Young, EYW Chan, XW Hu, R Köchl, SG Crawshaw, S High, ... Journal of cell science 119 (18), 3888-3900, 2006 | 982 | 2006 |
| RasGRP, a Ras guanyl nucleotide-releasing protein with calcium-and diacylglycerol-binding motifs JO Ebinu, DA Bottorff, EYW Chan, SL Stang, RJ Dunn, JC Stone Science 280 (5366), 1082-1086, 1998 | 823 | 1998 |
| Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1, 4, 5) triphosphate receptor type 1 TS Tang, H Tu, EYW Chan, A Maximov, Z Wang, CL Wellington, ... Neuron 39 (2), 227-239, 2003 | 604 | 2003 |
| siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy EYW Chan, S Kir, SA Tooze Journal of Biological Chemistry 282 (35), 25464-25474, 2007 | 535 | 2007 |
| Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes R Köchl, XW Hu, EYW Chan, SA Tooze Traffic 7 (2), 129-145, 2006 | 522 | 2006 |
| Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism EYW Chan, A Longatti, NC McKnight, SA Tooze Molecular and cellular biology 29 (1), 157-171, 2009 | 519 | 2009 |
| Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain R Luthi-Carter, SA Hanson, AD Strand, DA Bergstrom, W Chun, NL Peters, ... Human molecular genetics 11 (17), 1911-1926, 2002 | 454 | 2002 |
| Early endosomes and endosomal coatomer are required for autophagy M Razi, EYW Chan, SA Tooze Journal of Cell Biology 185 (2), 305-321, 2009 | 315 | 2009 |
| mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex EY Chan Science signaling 2 (84), pe51-pe51, 2009 | 263 | 2009 |
| Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo SC Warby, EY Chan, M Metzler, L Gan, RR Singaraja, SF Crocker, ... Human molecular genetics 14 (11), 1569-1577, 2005 | 191 | 2005 |
| Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease EYW Chan, R Luthi-Carter, A Strand, SM Solano, SA Hanson, ... Human molecular genetics 11 (17), 1939-1951, 2002 | 184 | 2002 |
| Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2 F McAlpine, LE Williamson, SA Tooze, EYW Chan Autophagy 9 (3), 361-373, 2013 | 174 | 2013 |
| Evolution of Atg1 function and regulation EY Chan, SA Tooze Autophagy 5 (6), 758-765, 2009 | 157 | 2009 |
| Advances in autophagy regulatory mechanisms LE Gallagher, LE Williamson, EYW Chan Cells 5 (2), 24, 2016 | 146 | 2016 |
| ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells M Karvela, P Baquero, EM Kuntz, A Mukhopadhyay, R Mitchell, EK Allan, ... Autophagy 12 (6), 936-948, 2016 | 107 | 2016 |
| Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior EYW Chan, J Nasir, CA Gutekunst, S Coleman, A Maclean, A Maas, ... Human molecular genetics 11 (8), 945-959, 2002 | 97 | 2002 |
| Targeting BCR-ABL-independent TKI resistance in chronic myeloid leukemia by mTOR and autophagy inhibition R Mitchell, LEM Hopcroft, P Baquero, EK Allan, K Hewit, D James, ... JNCI: Journal of the National Cancer Institute 110 (5), 467-478, 2018 | 94 | 2018 |
| AMPK inhibits ULK1-dependent autophagosome formation and lysosomal acidification via distinct mechanisms C Nwadike, LE Williamson, LE Gallagher, JL Guan, EYW Chan Molecular and cellular biology 38 (10), e00023-18, 2018 | 90 | 2018 |
| A novel pathway for tumor necrosis factor-α and ceramide signaling involving sequential activation of tyrosine kinase, p21ras, and phosphatidylinositol 3-kinase AN Hanna, EYW Chan, J Xu, JC Stone, DN Brindley Journal of Biological Chemistry 274 (18), 12722-12729, 1999 | 82 | 1999 |
Sharon A. ToozeThe Francis Crick InstituteAdresse e-mail validée de crick.ac.uk
