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Jackson Cahn
Jackson Cahn
Merck Protein Engineering
Bestätigte E-Mail-Adresse bei merck.com
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Zitiert von
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A general tool for engineering the NAD/NADP cofactor preference of oxidoreductases
JKB Cahn, CA Werlang, A Baumschlager, S Brinkmann-Chen, SL Mayo, ...
ACS synthetic biology 6 (2), 326-333, 2017
1272017
Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models
SC Dodani, G Kiss, JKB Cahn, Y Su, VS Pande, FH Arnold
Nature chemistry 8 (5), 419-425, 2016
1162016
General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH
S Brinkmann-Chen, T Flock, JKB Cahn, CD Snow, EM Brustad, ...
Proceedings of the National Academy of Sciences 110 (27), 10946-10951, 2013
1132013
Single-bacterial genomics validates rich and varied specialized metabolism of uncultivated Entotheonella sponge symbionts
T Mori, JKB Cahn, MC Wilson, RA Meoded, V Wiebach, AFC Martinez, ...
Proceedings of the National Academy of Sciences 115 (8), 1718-1723, 2018
732018
Directed evolution mimics allosteric activation by stepwise tuning of the conformational ensemble
AR Buller, P Van Roye, JKB Cahn, RA Scheele, M Herger, FH Arnold
Journal of the American Chemical Society 140 (23), 7256-7266, 2018
722018
Directed evolution of a bright near-infrared fluorescent rhodopsin using a synthetic chromophore
L Herwig, AJ Rice, CN Bedbrook, RK Zhang, A Lignell, JKB Cahn, ...
Cell chemical biology 24 (3), 415-425, 2017
622017
Structural, functional, and spectroscopic characterization of the substrate scope of the novel nitrating cytochrome P450 TxtE
SC Dodani, JKB Cahn, T Heinisch, S Brinkmann‐Chen, JA McIntosh, ...
ChemBioChem 15 (15), 2259-2267, 2014
502014
Mutations in adenine-binding pockets enhance catalytic properties of NAD (P) H-dependent enzymes
JKB Cahn, A Baumschlager, S Brinkmann-Chen, FH Arnold
Protein Engineering Design and Selection 29 (1), 31-38, 2016
402016
4S-Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation
SA Lieblich, KY Fang, JKB Cahn, J Rawson, J LeBon, HT Ku, DA Tirrell
Journal of the American Chemical Society 139 (25), 8384-8387, 2017
372017
The use of trimethylamine N-oxide as a primary precipitating agent and related methylamine osmolytes as cryoprotective agents for macromolecular crystallography
H Marshall, M Venkat, NS Hti Lar Seng, J Cahn, DH Juers
Acta Crystallographica Section D: Biological Crystallography 68 (1), 69-81, 2012
342012
Uncovering rare NADH-preferring ketol-acid reductoisomerases
S Brinkmann-Chen, JKB Cahn, FH Arnold
Metabolic engineering 26, 17-22, 2014
272014
Cofactor specificity motifs and the induced fit mechanism in Class I ketol-acid reductoisomerases
JKB Cahn, S Brinkmann-Chen, T Spatzal, JA Wiig, AR Buller, O Einsle, ...
Biochemical Journal 468 (3), 475-484, 2015
242015
A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds
P Moosmann, F Ecker, S Leopold-Messer, JKB Cahn, CL Dieterich, ...
Nature chemistry 12 (10), 968-972, 2020
192020
Cell adhesion to borate glasses by colloidal probe microscopy
SM Wiederhorn, YH Chae, CG Simon Jr, J Cahn, Y Deng, D Day
Acta biomaterialia 7 (5), 2256-2263, 2011
182011
Opening up the Single‐Cell Toolbox for Microbial Natural Products Research
J Cahn, J Piel
Angewandte Chemie International Edition, 2019
142019
The impact of cryosolution thermal contraction on proteins and protein crystals: volumes, conformation and order
DH Juers, CA Farley, CP Saxby, RA Cotter, JKB Cahn, RC Holton-Burke, ...
Acta Crystallographica Section D: Structural Biology 74 (9), 922-938, 2018
102018
Single-cell metabolite detection and genomics reveals uncultivated talented producer
M Kogawa, R Miyaoka, F Hemmerling, M Ando, K Yura, K Ide, ...
PNAS Nexus 1 (1), pgab007, 2022
82022
Characterization of an orphan type III polyketide synthase conserved in uncultivated “Entotheonella” sponge symbionts
S Reiter, JKB Cahn, V Wiebach, R Ueoka, J Piel
ChemBioChem 21 (4), 564-571, 2020
62020
Artificial domain duplication replicates evolutionary history of ketol‐acid reductoisomerases
JKB Cahn, S Brinkmann‐Chen, AR Buller, FH Arnold
Protein Science 25 (7), 1241-1248, 2015
62015
Enzyme nicotinamide cofactor specificity reversal guided by automated structural analysis and library design
JKB Cahn, S Brinkmann-Chen, FH Arnold
Synthetic Metabolic Pathways: Methods and Protocols, 15-26, 2018
42018
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