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Christina Lamers
Christina Lamers
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Year
Revealing the macromolecular targets of complex natural products
D Reker, AM Perna, T Rodrigues, P Schneider, M Reutlinger, B Mönch, ...
Nature chemistry 6 (12), 1072-1078, 2014
1172014
Therapeutic modulators of peroxisome proliferator-activated receptors (PPAR): a patent review (2008–present)
C Lamers, M Schubert-Zsilavecz, D Merk
Expert opinion on therapeutic patents 22 (7), 803-841, 2012
682012
Nonacidic farnesoid X receptor modulators
D Flesch, SY Cheung, J Schmidt, M Gabler, P Heitel, J Kramer, A Kaiser, ...
Journal of Medicinal Chemistry 60 (16), 7199-7205, 2017
532017
Extending the structure–activity relationship of anthranilic acid derivatives as Farnesoid X receptor modulators: Development of a highly potent partial Farnesoid X receptor …
D Merk, C Lamers, K Ahmad, R Carrasco Gomez, G Schneider, ...
Journal of Medicinal Chemistry 57 (19), 8035-8055, 2014
482014
N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators
R Blöcher, C Lamers, SK Wittmann, D Merk, M Hartmann, L Weizel, ...
Journal of medicinal chemistry 59 (1), 61-81, 2016
412016
Molecular tuning of farnesoid X receptor partial agonism
D Merk, S Sreeramulu, D Kudlinzki, K Saxena, V Linhard, SL Gande, ...
Nature communications 10 (1), 1-14, 2019
402019
Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR)
D Merk, M Gabler, RC Gomez, D Flesch, T Hanke, A Kaiser, C Lamers, ...
Bioorganic & medicinal chemistry 22 (8), 2447-2460, 2014
292014
Medicinal chemistry and pharmacological effects of Farnesoid X Receptor (FXR) antagonists
C Lamers, M Schubert-Zsilavecz, D Merk
Current topics in medicinal chemistry 14 (19), 2188-2205, 2014
272014
Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors
E Buscató, R Blöcher, C Lamers, FM Klingler, S Hahn, D Steinhilber, ...
Journal of medicinal chemistry 55 (23), 10771-10775, 2012
272012
Anthranilic acid derivatives as nuclear receptor modulators—Development of novel PPAR selective and dual PPAR/FXR ligands
D Merk, C Lamers, J Weber, D Flesch, M Gabler, E Proschak, ...
Bioorganic & medicinal chemistry 23 (3), 499-514, 2015
252015
Cyclic peptide FXII inhibitor provides safe anticoagulation in a thrombosis model and in artificial lungs
J Wilbs, XD Kong, SJ Middendorp, R Prince, A Cooke, CT Demarest, ...
Nature communications 11 (1), 1-13, 2020
222020
Novel prostaglandin receptor modulators–Part II: EP receptor modulators; a patent review (2002–2012)
D Flesch, D Merk, C Lamers, M Schubert-Zsilavecz
Expert opinion on therapeutic patents 23 (2), 233-267, 2013
152013
Macrocyclization strategies for cyclic peptides and peptidomimetics
C Bechtler, C Lamers
RSC medicinal chemistry, 2021
132021
Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition
T Hanke, C Lamers, RC Gomez, G Schneider, O Werz, ...
Bioorganic & medicinal chemistry letters 24 (16), 3757-3763, 2014
132014
Novel prostaglandin receptor modulators: a patent review (2002–2012)–part I: non-EP receptor modulators
C Lamers, D Flesch, M Schubert-Zsilavecz, D Merk
Expert opinion on therapeutic patents 23 (1), 47-77, 2013
132013
Molecular determinants for improved activity at PPARα: Structure–activity relationship of pirinixic acid derivatives, docking study and site-directed mutagenesis of PPARα
C Lamers, M Dittrich, R Steri, E Proschak, M Schubert-Zsilavecz
Bioorganic & Medicinal Chemistry Letters 24 (16), 4048-4052, 2014
102014
SAR studies on FXR modulators led to the discovery of the first combined FXR antagonistic/TGR5 agonistic compound
C Lamers, D Merk, M Gabler, D Flesch, A Kaiser, M Schubert-Zsilavecz
Future medicinal chemistry 8 (2), 133-148, 2016
92016
The promiscuous profile of complement receptor 3 in ligand binding, immune modulation, and pathophysiology
C Lamers, CJ Plüss, D Ricklin
Frontiers in immunology 12, 662164, 2021
72021
Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators
R Blöcher, C Lamers, SK Wittmann, O Diehl, T Hanke, D Merk, ...
MedChemComm 7 (6), 1209-1216, 2016
72016
SAR-studies of γ-secretase modulators with PPARγ-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer’s disease
D Flesch, J Ness, C Lamers, F Dehm, S Popella, R Steri, I Ogorek, ...
Bioorganic & Medicinal Chemistry Letters 25 (4), 841-846, 2015
62015
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