| Expansion and length-dependent fragility of CTG repeats in yeast CH Freudenreich, SM Kantrow, VA Zakian Science 279 (5352), 853-856, 1998 | 477 | 1998 |
| Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome CH Freudenreich, JB Stavenhagen, VA Zakian Molecular and cellular biology, 1997 | 279 | 1997 |
| An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae H Zhang, CH Freudenreich Molecular cell 27 (3), 367-379, 2007 | 200 | 2007 |
| Repeat instability during DNA repair: Insights from model systems K Usdin, NCM House, CH Freudenreich Critical reviews in biochemistry and molecular biology 50 (2), 142-167, 2015 | 185 | 2015 |
| Chromatin modifications and DNA repair: beyond double-strand breaks NCM House, MR Koch, CH Freudenreich Frontiers in genetics 5, 296, 2014 | 137 | 2014 |
| Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility JL Callahan, KJ Andrews, VA Zakian, CH Freudenreich Molecular and cellular biology 23 (21), 7849-7860, 2003 | 124 | 2003 |
| Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability XA Su, V Dion, SM Gasser, CH Freudenreich Genes & development 29 (10), 1006-1017, 2015 | 120 | 2015 |
| Repeat expansions confer WRN dependence in microsatellite-unstable cancers N van Wietmarschen, S Sridharan, WJ Nathan, A Tubbs, EM Chan, ... Nature 586 (7828), 292-298, 2020 | 112 | 2020 |
| Localization of an aminoacridine antitumor agent in a type II topoisomerase-DNA complex. CH Freudenreich, KN Kreuzer Proceedings of the National Academy of Sciences 91 (23), 11007-11011, 1994 | 110 | 1994 |
| Trinucleotide repeat instability: a hairpin curve at the crossroads of replication, recombination, and repair BA Lenzmeier, CH Freudenreich Cytogenetic and genome research 100 (1-4), 7-24, 2003 | 109 | 2003 |
| SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination A Kerrest, RP Anand, R Sundararajan, R Bermejo, G Liberi, B Dujon, ... Nature structural & molecular biology 16 (2), 159-167, 2009 | 104 | 2009 |
| CGG/CCG repeats exhibit orientation-dependent instability and orientation-independent fragility in Saccharomyces cerevisiae BS Balakumaran, CH Freudenreich, VA Zakian Human molecular genetics 9 (1), 93-100, 2000 | 104 | 2000 |
| Saccharomyces cerevisiae Flap Endonuclease 1 Uses Flap Equilibration To Maintain Triplet Repeat Stability Y Liu, H Zhang, J Veeraraghavan, RA Bambara, CH Freudenreich Molecular and cellular biology 24 (9), 4049-4064, 2004 | 93 | 2004 |
| Overcoming natural replication barriers: differential helicase requirements RP Anand, KA Shah, H Niu, P Sung, SM Mirkin, CH Freudenreich Nucleic acids research 40 (3), 1091-1105, 2012 | 90 | 2012 |
| Expanded CAG repeats activate the DNA damage checkpoint pathway M Lahiri, TL Gustafson, ER Majors, CH Freudenreich Molecular cell 15 (2), 287-293, 2004 | 88 | 2004 |
| Cytosine deamination and base excision repair cause R-loop–induced CAG repeat fragility and instability in Saccharomyces cerevisiae XA Su, CH Freudenreich Proceedings of the National Academy of Sciences 114 (40), E8392-E8401, 2017 | 86 | 2017 |
| Mutational analysis of a type II topoisomerase cleavage site: distinct requirements for enzyme and inhibitors. CH Freudenreich, KN Kreuzer The EMBO Journal 12 (5), 2085-2097, 1993 | 83 | 1993 |
| Chromosome fragility: molecular mechanisms and cellular consequences CH Freudenreich Front Biosci 12 (12), 4911, 2007 | 78 | 2007 |
| The role of fork stalling and DNA structures in causing chromosome fragility S Kaushal, CH Freudenreich Genes, Chromosomes and Cancer 58 (5), 270-283, 2019 | 73 | 2019 |
| Double-strand break repair pathways protect against CAG/CTG repeat expansions, contractions and repeat-mediated chromosomal fragility in Saccharomyces cerevisiae R Sundararajan, L Gellon, RM Zunder, CH Freudenreich Genetics 184 (1), 65-77, 2010 | 67 | 2010 |
