| Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals JM Flynn, SB Neher, YI Kim, RT Sauer, TA Baker Molecular cell 11 (3), 671-683, 2003 | 718 | 2003 |
| Sculpting the proteome with AAA+ proteases and disassembly machines RT Sauer, DN Bolon, BM Burton, RE Burton, JM Flynn, RA Grant, ... Cell 119 (1), 9-18, 2004 | 526 | 2004 |
| Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis JM Flynn, I Levchenko, M Seidel, SH Wickner, RT Sauer, TA Baker Proceedings of the National Academy of Sciences 98 (19), 10584-10589, 2001 | 374 | 2001 |
| Modulating substrate choice: the SspB adaptor delivers a regulator of the extracytoplasmic-stress response to the AAA+ protease ClpXP for degradation JM Flynn, I Levchenko, RT Sauer, TA Baker Genes & development 18 (18), 2292-2301, 2004 | 259 | 2004 |
| Latent ClpX-recognition signals ensure LexA destruction after DNA damage SB Neher, JM Flynn, RT Sauer, TA Baker Genes & development 17 (9), 1084-1089, 2003 | 156 | 2003 |
| Design principles of the proteolytic cascade governing the σE-mediated envelope stress response in Escherichia coli: keys to graded, buffered, and rapid signal transduction R Chaba, IL Grigorova, JM Flynn, TA Baker, CA Gross Genes & development 21 (1), 124-136, 2007 | 136 | 2007 |
| Systematic mutant analyses elucidate general and client-specific aspects of Hsp90 function P Mishra, JM Flynn, TN Starr, DNA Bolon Cell reports 15 (3), 588-598, 2016 | 114 | 2016 |
| Pervasive contingency and entrenchment in a billion years of Hsp90 evolution TN Starr, JM Flynn, P Mishra, DNA Bolon, JW Thornton Proceedings of the National Academy of Sciences 115 (17), 4453-4458, 2018 | 100 | 2018 |
| Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms JM Flynn, N Samant, G Schneider-Nachum, DT Barkan, NK Yilmaz, ... Elife 11, e77433, 2022 | 59 | 2022 |
| Viewing protein fitness landscapes through a next-gen lens JI Boucher, P Cote, J Flynn, L Jiang, A Laban, P Mishra, BP Roscoe, ... Genetics 198 (2), 461-471, 2014 | 59 | 2014 |
| Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments K Nakano, J Chen, GE Tarr, T Yoshida, JM Flynn, MW Bitensky Proceedings of the National Academy of Sciences 98 (8), 4693-4698, 2001 | 58 | 2001 |
| Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance AM Shaqra, SN Zvornicanin, QYJ Huang, GJ Lockbaum, M Knapp, ... Nature communications 13 (1), 3556, 2022 | 57 | 2022 |
| Comprehensive fitness maps of Hsp90 show widespread environmental dependence JM Flynn, A Rossouw, P Cote-Hammarlof, I Fragata, D Mavor, C Hollins III, ... Elife 9, e53810, 2020 | 56 | 2020 |
| Versatile modes of peptide recognition by the AAA+ adaptor protein SspB I Levchenko, RA Grant, JM Flynn, RT Sauer, TA Baker Nature structural & molecular biology 12 (6), 520-525, 2005 | 54 | 2005 |
| Mechanistic asymmetry in Hsp90 dimers JM Flynn, P Mishra, DNA Bolon Journal of molecular biology 427 (18), 2904-2911, 2015 | 36 | 2015 |
| Evolutionary mechanisms studied through protein fitness landscapes AS Canale, PA Cote-Hammarlof, JM Flynn, DNA Bolon Current opinion in structural biology 48, 141-148, 2018 | 33 | 2018 |
| Expression of N-formylated proteins in Escherichia coli S Spector, JM Flynn, B Tidor, TA Baker, RT Sauer Protein expression and purification 32 (2), 317-322, 2003 | 26 | 2003 |
| The adaptive potential of the middle domain of yeast Hsp90 PA Cote-Hammarlof, I Fragata, J Flynn, D Mavor, KB Zeldovich, C Bank, ... Molecular Biology and Evolution 38 (2), 368-379, 2021 | 10 | 2021 |
| Systematic analyses of the resistance potential of drugs targeting SARS-CoV-2 main protease JM Flynn, QYJ Huang, SN Zvornicanin, G Schneider-Nachum, AM Shaqra, ... ACS infectious diseases 9 (7), 1372-1386, 2023 | 7 | 2023 |
| A complete allosteric map of a GTPase switch in its native cellular network CJP Mathy, P Mishra, JM Flynn, T Perica, D Mavor, DNA Bolon, ... Cell Systems 14 (3), 237-246. e7, 2023 | 7 | 2023 |
