Julia Flynn
Julia Flynn
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Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals
JM Flynn, SB Neher, YI Kim, RT Sauer, TA Baker
Molecular cell 11 (3), 671-683, 2003
Sculpting the proteome with AAA+ proteases and disassembly machines
RT Sauer, DN Bolon, BM Burton, RE Burton, JM Flynn, RA Grant, ...
Cell 119 (1), 9-18, 2004
Overlapping recognition determinants within the ssrA degradation tag allow modulation of proteolysis
JM Flynn, I Levchenko, M Seidel, SH Wickner, RT Sauer, TA Baker
Proceedings of the National Academy of Sciences 98 (19), 10584-10589, 2001
Modulating substrate choice: the SspB adaptor delivers a regulator of the extracytoplasmic-stress response to the AAA+ protease ClpXP for degradation
JM Flynn, I Levchenko, RT Sauer, TA Baker
Genes & development 18 (18), 2292-2301, 2004
Latent ClpX-recognition signals ensure LexA destruction after DNA damage
SB Neher, JM Flynn, RT Sauer, TA Baker
Genes & development 17 (9), 1084-1089, 2003
Design principles of the proteolytic cascade governing the σE-mediated envelope stress response in Escherichia coli: keys to graded, buffered, and rapid signal transduction
R Chaba, IL Grigorova, JM Flynn, TA Baker, CA Gross
Genes & development 21 (1), 124-136, 2007
Systematic mutant analyses elucidate general and client-specific aspects of Hsp90 function
P Mishra, JM Flynn, TN Starr, DNA Bolon
Cell reports 15 (3), 588-598, 2016
Pervasive contingency and entrenchment in a billion years of Hsp90 evolution
TN Starr, JM Flynn, P Mishra, DNA Bolon, JW Thornton
Proceedings of the National Academy of Sciences 115 (17), 4453-4458, 2018
Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments
K Nakano, J Chen, GE Tarr, T Yoshida, JM Flynn, MW Bitensky
Proceedings of the National Academy of Sciences 98 (8), 4693-4698, 2001
Viewing protein fitness landscapes through a next-gen lens
JI Boucher, P Cote, J Flynn, L Jiang, A Laban, P Mishra, BP Roscoe, ...
Genetics 198 (2), 461-471, 2014
Versatile modes of peptide recognition by the AAA+ adaptor protein SspB
I Levchenko, RA Grant, JM Flynn, RT Sauer, TA Baker
Nature structural & molecular biology 12 (6), 520-525, 2005
Mechanistic asymmetry in Hsp90 dimers
JM Flynn, P Mishra, DNA Bolon
Journal of molecular biology 427 (18), 2904-2911, 2015
Evolutionary mechanisms studied through protein fitness landscapes
AS Canale, PA Cote-Hammarlof, JM Flynn, DNA Bolon
Current opinion in structural biology 48, 141-148, 2018
Comprehensive fitness maps of Hsp90 show widespread environmental dependence
JM Flynn, A Rossouw, P Cote-Hammarlof, I Fragata, D Mavor, C Hollins III, ...
Elife 9, e53810, 2020
Expression of N-formylated proteins in Escherichia coli
S Spector, JM Flynn, B Tidor, TA Baker, RT Sauer
Protein expression and purification 32 (2), 317-322, 2003
The adaptive potential of the middle domain of yeast Hsp90
PA Cote-Hammarlof, I Fragata, J Flynn, D Mavor, KB Zeldovich, C Bank, ...
Molecular biology and evolution 38 (2), 368-379, 2021
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance
AM Shaqra, SN Zvornicanin, QYJ Huang, GJ Lockbaum, M Knapp, ...
Nature communications 13 (1), 1-11, 2022
Substrate selection by the ClpXP protease: a tail of destruction
JM Flynn
Massachusetts Institute of Technology, 2004
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
JM Flynn, N Samant, G Schneider-Nachum, DT Bakan, NK Yilmaz, ...
Elife 11, e77433, 2022
Analyses of HIV proteases variants at the threshold of viability reveals relationships between processing efficiency and fitness
G Schneider-Nachum, J Flynn, D Mavor, CA Schiffer, DNA Bolon
Virus evolution 7 (2), veab103, 2021
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