| PROTAC-mediated degradation of Bruton’s tyrosine kinase is inhibited by covalent binding CP Tinworth, H Lithgow, L Dittus, ZI Bassi, SE Hughes, M Muelbaier, ... ACS chemical biology 14 (3), 342-347, 2019 | 146 | 2019 |
| Facts, patterns, and principles in drug discovery: Appraising the rule of 5 with measured physicochemical data CP Tinworth, RJ Young Journal of medicinal chemistry 63 (18), 10091-10108, 2020 | 73 | 2020 |
| Structural insights into PROTAC-mediated degradation of Bcl-xL C Chung, H Dai, E Fernandez, CP Tinworth, I Churcher, J Cryan, ... ACS Chemical Biology 15 (9), 2316-2323, 2020 | 59 | 2020 |
| Small Molecule-Mediated Protein Knockdown as a New Approach to Drug Discovery CP Tinworth, H Lithgow, I Churcher | 41 | 2016 |
| Targeting the regulatory site of ER aminopeptidase 1 leads to the discovery of a natural product modulator of antigen presentation J Liddle, JP Hutchinson, S Kitchen, P Rowland, M Neu, T Cecconie, ... Journal of Medicinal Chemistry 63 (6), 3348-3358, 2020 | 24 | 2020 |
| Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs) ED Vita Chemical Communications 58 (78), 10933-10936, 2022 | 15 | 2022 |
| Computational mapping of dirhodium (ii) catalysts AI Green, CP Tinworth, S Warriner, A Nelson, N Fey Chemistry–A European Journal 27 (7), 2402-2409, 2021 | 14 | 2021 |
| Activity‐Directed Synthesis of Inhibitors of the p53/hDM2 Protein–Protein Interaction AI Green, F Hobor, CP Tinworth, S Warriner, AJ Wilson, A Nelson Chemistry–A European Journal 26 (47), 10682-10689, 2020 | 14 | 2020 |
| A two-faced selectivity solution to target SMARCA2 for cancer therapy JD Harling, CP Tinworth nature communications 14 (1), 515, 2023 | 3 | 2023 |
| Novel compounds JD Harling, C Tinworth US Patent App. 16/326,234, 2019 | 1 | 2019 |
| Identification of a small molecule for enhancing lentiviral transduction of T cells P Malach, C Kay, C Tinworth, F Patel, B Joosse, J Wade, MR do Carmo, ... Molecular Therapy-Methods & Clinical Development 31, 2023 | | 2023 |
| Cover Feature: Activity‐Directed Synthesis of Inhibitors of the p53/hDM2 Protein–Protein Interaction (Chem. Eur. J. 47/2020) AI Green, F Hobor, CP Tinworth, S Warriner, AJ Wilson, A Nelson Chemistry–A European Journal 26 (47), 10645-10645, 2020 | | 2020 |
| Novel Compounds JD Harling, C Tinworth US Patent App. 16/308,542, 2019 | | 2019 |
| Targeted protein degradation as a new approach to drug discovery CP Tinworth | | 2017 |
Ian ChurcherGSKVerified email at gsk.com
