| E-cadherin and LGN align epithelial cell divisions with tissue tension independently of cell shape KC Hart, J Tan, KA Siemers, JY Sim, BL Pruitt, WJ Nelson, M Gloerich Proceedings of the National Academy of Sciences 114 (29), E5845-E5853, 2017 | 99 | 2017 |
| Spatial distribution of cell–cell and cell–ECM adhesions regulates force balance while maintaining E-cadherin molecular tension in cell pairs JY Sim, J Moeller, KC Hart, D Ramallo, V Vogel, AR Dunn, WJ Nelson, ... Molecular biology of the cell 26 (13), 2456-2465, 2015 | 92 | 2015 |
| Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis BW Benham-Pyle, JY Sim, KC Hart, BL Pruitt, WJ Nelson Elife 5, e19799, 2016 | 48 | 2016 |
| LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining KS Lawrence, EC Tapley, VE Cruz, Q Li, K Aung, KC Hart, TU Schwartz, ... Journal of Cell Biology 215 (6), 801-821, 2016 | 45 | 2016 |
| An easy-to-fabricate cell stretcher reveals density-dependent mechanical regulation of collective cell movements in epithelia KC Hart, JY Sim, MA Hopcroft, DJ Cohen, J Tan, WJ Nelson, BL Pruitt Cellular and Molecular Bioengineering 14, 569-581, 2021 | 9 | 2021 |
| High valency of IGM-2323, a CD20xCD3 IgM bispecific T cell engager, displaces rituximab binding and induces potent B lymphoma cell killing KC Hart, K Logronio, M Li, P Yakkundi, M Manlusoc, K Li, PR Hinton, ... Cancer Research 82 (12), 2022 | 1 | 2022 |
| Mechanistic evaluation of anti-DR5 IgM antibody IGM-8444 with potent tumor cytotoxicity, without in vitro hepatotoxicity BT Wang, T Kothambawala, KC Hart, X Chen, M Desbois, SE Calhoun, ... Proceedings of the American Association for Cancer Research Annual Meeting …, 2021 | 1 | 2021 |
| Novel combinations of aplitabart, a DR5 agonist IgM antibody, with ADCs or chemotherapeutic agents lead to robust anti-tumor responses in solid tumor models M Desbois, SE Calhoun, KC Hart, CR Denson, P Yakkundi, TJ Matthew, ... Cancer Research 84 (6_Supplement), 1899-1899, 2024 | | 2024 |
| IGM-2644, a CD38xCD3 bispecific IgM T cell engager, shows enhanced anti-tumor activity compared to daratumumab in preclinical models of multiple myeloma KC Hart, D Santos, K Li, R Yun, M Chai, A Kabai, G Li, P Yakkundi, ... Cancer Research 84 (6_Supplement), 1237-1237, 2024 | | 2024 |
| Uses of effector cell engaging molecules with moieties of differing potencies DS Chen, WR Godfrey, MGH Hernandez, I Sison, Q Ibrahim, KC Hart, ... US Patent App. 18/252,759, 2024 | | 2024 |
| P-047 Trial in progress: an open-label, multicenter, phase 1 study for IGM-2644 in participants with relapsed and/or refractory multiple myeloma (RRMM) R Funke, H Schade, J Berdeja, K Li, M Kotturi, G Hernandez, Y Guan, ... Clinical Lymphoma Myeloma and Leukemia 23, S60-S61, 2023 | | 2023 |
| P815: HIGH VALENCY OF IGM-2644, A CD38XCD3 IGM BISPECIFIC T CELL ENGAGER, DISPLACES DARATUMUMAB BINDING AND INDUCES POTENT MULTIPLE MYELOMA CELL KILLING KC Hart, D Santos, D Pandya, R Deng, LI Keyu, Y Guan, G Hernandez, ... HemaSphere 7 (S3), e630565c, 2023 | | 2023 |
| Novel CD38xCD3 Bispecific IgM T Cell Engager, IGM-2644, Potently Kills Multiple Myeloma Cells Through Complement and T Cell Dependent Mechanisms K Li, R Yun, M Chai, P Yakkundi, R Rosete, G Li, L Liu, M Li, D Santos, ... Cancer Research 83 (7_Supplement), 2959-2959, 2023 | | 2023 |
| P1276: DOSE RESPONSE PROFILE OF IGM-2323, A CD20XCD3 IGM BISPECIFIC T CELL ENGAGER, IN TRANSLATIONAL MODELS SUPPORTS PHASE 2 DOSE SELECTION IN NON-HODGKIN’S LYMPHOMA MK Leabman, G Hernandez, CM Ng, J Tang, D Pandya, KC Hart, K Li, ... HemaSphere 6, 1161-1162, 2022 | | 2022 |
| Uses of effector cell engaging molecules with moieties of differing potencies MFK Daniel S. Chen, Wayne R. Godfrey, Maria Genevive Hermoso Hernandez, Iris ... WO Patent WO2022109023A1, 2022 | | 2022 |
| Mechanical Regulation of E-Cadherin Adhesion and Signaling in Epithelia K Hart Stanford University, 2018 | | 2018 |
| Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle BW Benham-Pyle, JY Sim, KC Hart | | 2016 |
| Increasing beta-catenin/Wnt3A Activity Levels Drive Mechanical Strain-Induced Epithelial Cell Cycle Progression through Mitosis. BW Benham-Pyle, J Sim, KC Hart, BL Pruitt, WJ Nelson MOLECULAR BIOLOGY OF THE CELL 27, 2016 | | 2016 |
| The Mechano-Responsive E-cadherin/LGN Complex Instructs Epithelial Cell Division Orientation. M Gloerich, KC Hart, JM Bianchini, KA Siemers, DJ Cohen, J Tan, J Sim, ... MOLECULAR BIOLOGY OF THE CELL 27, 2016 | | 2016 |
| A Highlights from MBoC Selection: Spatial distribution of cell–cell and cell–ECM adhesions regulates force balance while maintaining E-cadherin molecular tension in cell pairs JY Sim, J Moeller, KC Hart, D Ramallo, V Vogel, AR Dunn, WJ Nelson, ... Molecular Biology of the Cell 26 (13), 2456, 2015 | | 2015 |
