| Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal EM Pietras, C Mirantes-Barbeito, S Fong, D Loeffler, LV Kovtonyuk, ... Nature cell biology 18 (6), 607-618, 2016 | 606 | 2016 |
| Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment LV Kovtonyuk, K Fritsch, X Feng, MG Manz, H Takizawa Frontiers in immunology 7, 502, 2016 | 343 | 2016 |
| Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling ML Balmer, CM Schürch, Y Saito, MB Geuking, H Li, M Cuenca, ... The Journal of Immunology 193 (10), 5273-5283, 2014 | 264 | 2014 |
| Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic stem cells promotes proliferation but reduces competitive fitness H Takizawa, K Fritsch, LV Kovtonyuk, Y Saito, C Yakkala, K Jacobs, ... Cell stem cell 21 (2), 225-240. e5, 2017 | 252 | 2017 |
| IL-1 mediates microbiome-induced inflammaging of hematopoietic stem cells in mice LV Kovtonyuk, F Caiado, S Garcia-Martin, EM Manz, P Helbling, ... Blood, The Journal of the American Society of Hematology 139 (1), 44-58, 2022 | 68 | 2022 |
| Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo LV Kovtonyuk, MG Manz, H Takizawa Blood, The Journal of the American Society of Hematology 127 (25), 3175-3179, 2016 | 56 | 2016 |
| inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice JM Ellegast, PJ Rauch, LV Kovtonyuk, R Müller, U Wagner, Y Saito, ... Blood, The Journal of the American Society of Hematology 128 (17), 2130-2134, 2016 | 45 | 2016 |
| Aging drives Tet2+/− clonal hematopoiesis via IL-1 signaling F Caiado, LV Kovtonyuk, NG Gonullu, J Fullin, S Boettcher, MG Manz Blood 141 (8), 886-903, 2023 | 43 | 2023 |
| Immunotherapy of hepatocellular carcinoma with small double-stranded RNA TO Kabilova, LV Kovtonyuk, EV Zonov, EI Ryabchikova, NA Popova, ... BMC cancer 14, 1-11, 2014 | 35 | 2014 |
| Fas (CD 95) expression in myeloid cells promotes obesity‐induced muscle insulin resistance S Wueest, R Mueller, M Blüher, F Item, ASH Chin, MSF Wiedemann, ... EMBO molecular medicine 6 (1), 43-56, 2014 | 31 | 2014 |
| Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness S Isringhausen, YV Mun, L Kovtonyuk, NJ Kräutler, U Suessbier, ... Journal of Experimental Medicine 218 (12), e20192070, 2021 | 30 | 2021 |
| Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment. Front Immunol. 2016; 7: 502 LV Kovtonyuk, K Fritsch, X Feng, MG Manz, H Takizawa This comprehensive review present evidence supporting the concept of …, 2016 | 18 | 2016 |
| CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis RC Gerosa, S Boettcher, LV Kovtonyuk, A Hausmann, WD Hardt, ... Blood advances 5 (23), 5002-5015, 2021 | 12 | 2021 |
| Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic stem cells promotes proliferation but reduces competitive fitness H Takizawa, K Fritsch, LV Kovtonyuk, Y Saito, C Yakkala, K Jacobs, ... Cell Stem Cell 27 (1), 177, 2020 | 12 | 2020 |
| A single metabolite which modulates lipid metabolism alters hematopoietic stem/progenitor cell behavior and promotes lymphoid reconstitution S Giger, LV Kovtonyuk, SG Utz, M Ramosaj, WJ Kovacs, E Schmid, ... Stem cell reports 15 (3), 566-576, 2020 | 11 | 2020 |
| TP53 mutations confer resistance to hypomethylating agents and BCL-2 inhibition in myeloid neoplasms RR Schimmer, LV Kovtonyuk, N Klemm, J Fullin, SM Stolz, J Mueller, ... Blood advances 6 (11), 3201-3206, 2022 | 10 | 2022 |
| Humanised mouse models for haematopoiesis and infectious diseases V Lysenko, D McHugh, L Behrmann, MA Rochat, CM Wilk, LV Kovtonyuk, ... Swiss medical weekly 147, w14516, 2017 | 9 | 2017 |
| Hematopoietic stem cells increase quiescence during aging LV Kovtonyuk, P Ashcroft, G Spaltro, NR Tata, RC Skoda, S Bonhoeffer, ... Blood 134, 2484, 2019 | 5 | 2019 |
| Microbial metabolites and immunotherapy: Basic rationale and clinical indications LV Kovtonyuk, KD McCoy Seminars in immunology 67, 101755, 2023 | 4 | 2023 |
| Clonal dynamics after allogeneic haematopoietic cell transplantation using genome-wide somatic mutations P Campbell, MS Chapman, M Wilk, S Boettcher, E Mitchell, K Dawson, ... | 3 | 2023 |
Hitoshi TakizawaInternational Research Center for Medical Sciences, Kumamoto UniversityVerified email at kumamoto-u.ac.jp
