Francesco Iorio
Francesco Iorio
Wellcome Sanger Institute
Verified email at sanger.ac.uk
Title
Cited by
Cited by
Year
Systematic identification of genomic markers of drug sensitivity in cancer cells
MJ Garnett, EJ Edelman, SJ Heidorn, CD Greenman, A Dastur, KW Lau, ...
Nature 483 (7391), 570-575, 2012
18552012
Prospective derivation of a living organoid biobank of colorectal cancer patients
M van de Wetering, HE Francies, JM Francis, G Bounova, F Iorio, A Pronk, ...
Cell 161 (4), 933-945, 2015
9562015
A landscape of pharmacogenomic interactions in cancer
F Iorio, TA Knijnenburg, DJ Vis, GR Bignell, MP Menden, M Schubert, ...
Cell 166 (3), 740-754, 2016
7452016
Discovery of drug mode of action and drug repositioning from transcriptional responses
F Iorio, R Bosotti, E Scacheri, V Belcastro, P Mithbaokar, R Ferriero, ...
Proceedings of the National Academy of Sciences 107 (33), 14621-14626, 2010
6472010
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma
N Bolli, H Avet-Loiseau, DC Wedge, P Van Loo, LB Alexandrov, ...
Nature communications 5 (1), 1-13, 2014
6222014
Drug repurposing: progress, challenges and recommendations
S Pushpakom, F Iorio, PA Eyers, KJ Escott, S Hopper, A Wells, A Doig, ...
Nature reviews Drug discovery 18 (1), 41-58, 2019
5842019
A yeast synthetic network for in vivo assessment of reverse-engineering and modeling approaches
I Cantone, L Marucci, F Iorio, MA Ricci, V Belcastro, M Bansal, S Santini, ...
Cell 137 (1), 172-181, 2009
3802009
Machine learning prediction of cancer cell sensitivity to drugs based on genomic and chemical properties
MP Menden, F Iorio, M Garnett, U McDermott, CH Benes, PJ Ballester, ...
PLoS one 8 (4), e61318, 2013
2932013
A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia
K Tzelepis, H Koike-Yusa, E De Braekeleer, Y Li, E Metzakopian, ...
Cell reports 17 (4), 1193-1205, 2016
2782016
Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens
FM Behan, F Iorio, G Picco, E Gonçalves, CM Beaver, G Migliardi, ...
Nature 568 (7753), 511-516, 2019
2232019
Transcriptional data: a new gateway to drug repositioning?
F Iorio, T Rittman, H Ge, M Menden, J Saez-Rodriguez
Drug discovery today 18 (7-8), 350-357, 2013
1762013
Pharmacogenomic agreement between two cancer cell line data sets
Cancer Cell Line Encyclopedia Consortium, ...
Nature 528 (7580), 84, 2015
1642015
BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model
D Perna, FA Karreth, AG Rust, PA Perez-Mancera, M Rashid, F Iorio, ...
Proceedings of the National Academy of Sciences 112 (6), E536-E545, 2015
1072015
Transcriptional gene network inference from a massive dataset elucidates transcriptome organization and gene function
V Belcastro, V Siciliano, F Gregoretti, P Mithbaokar, G Dharmalingam, ...
Nucleic acids research 39 (20), 8677-8688, 2011
1002011
Identifying network of drug mode of action by gene expression profiling
F Iorio, R Tagliaferri, D Bernardo
Journal of Computational Biology 16 (2), 241-251, 2009
932009
Characterizing mutational signatures in human cancer cell lines reveals episodic APOBEC mutagenesis
M Petljak, LB Alexandrov, JS Brammeld, S Price, DC Wedge, ...
Cell 176 (6), 1282-1294. e20, 2019
822019
Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts
A Mupo, M Seiler, V Sathiaseelan, A Pance, Y Yang, AA Agrawal, F Iorio, ...
Leukemia 31 (3), 720-727, 2017
712017
Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors
P Casado, MP Alcolea, F Iorio, JC Rodríguez-Prados, B Vanhaesebroeck, ...
Genome biology 14 (4), 1-18, 2013
562013
DvD: An R/Cytoscape pipeline for drug repurposing using public repositories of gene expression data
C Pacini, F Iorio, E Gonçalves, M Iskar, T Klabunde, P Bork, ...
Bioinformatics 29 (1), 132-134, 2013
562013
Identification of small molecules enhancing autophagic function from drug network analysis
F Iorio, A Isacchi, D di Bernardo, N Brunetti-Pierri
Autophagy 6 (8), 1204-1205, 2010
522010
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Articles 1–20