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Roman P. Jakob
Roman P. Jakob
Bestätigte E-Mail-Adresse bei unibas.ch
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Catch-bond mechanism of the bacterial adhesin FimH
MM Sauer, RP Jakob, J Eras, S Baday, D Eriş, G Navarra, S Berneche, ...
Nature communications 7 (1), 10738, 2016
2352016
The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase
H Kaur, RP Jakob, JK Marzinek, R Green, Y Imai, JR Bolla, E Agustoni, ...
Nature 593 (7857), 125-129, 2021
1462021
The structural basis of autotransporter translocation by TamA
F Gruss, F Zähringer, RP Jakob, BM Burmann, S Hiller, T Maier
Nature structural & molecular biology 20 (11), 1318-1320, 2013
1352013
Increased Folding Stability of TEM-1 β-Lactamase by In Vitro Selection
I Kather, RP Jakob, H Dobbek, FX Schmid
Journal of molecular biology 383 (1), 238-251, 2008
1062008
FimH antagonists: bioisosteres to improve the in vitro and in vivo PK/PD profile
S Kleeb, L Pang, K Mayer, D Eris, A Sigl, RC Preston, P Zihlmann, ...
American Chemical Society, 2015
1052015
Binding of the bacterial adhesin FimH to its natural, multivalent high-mannose type glycan targets
MM Sauer, RP Jakob, T Luber, F Canonica, G Navarra, B Ernst, ...
Journal of the American Chemical Society 141 (2), 936-944, 2018
972018
Long-lived T follicular helper cells retain plasticity and help sustain humoral immunity
M Künzli, D Schreiner, TC Pereboom, N Swarnalekha, LC Litzler, ...
Science immunology 5 (45), eaay5552, 2020
932020
Quercetinase QueD of Streptomyces sp. FLA, a Monocupin Dioxygenase with a Preference for Nickel and Cobalt
H Merkens, R Kappl, RP Jakob, FX Schmid, S Fetzner
Biochemistry 47 (46), 12185-12196, 2008
902008
Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthases
DA Herbst, RP Jakob, F Zähringer, T Maier
Nature 531 (7595), 533-537, 2016
872016
Chaperone domains convert prolyl isomerases into generic catalysts of protein folding
RP Jakob, G Zoldák, T Aumüller, FX Schmid
Proceedings of the National Academy of Sciences 106 (48), 20282-20287, 2009
802009
Xenobiotic Reductase A in the Degradation of Quinoline by Pseudomonas putida 86: Physiological Function, Structure and Mechanism of 8-Hydroxycoumarin …
JJ Griese, RP Jakob, S Schwarzinger, H Dobbek
Journal of molecular biology 361 (1), 140-152, 2006
752006
E-selectin ligand complexes adopt an extended high-affinity conformation
RC Preston, RP Jakob, FPC Binder, CP Sager, B Ernst, T Maier
Journal of molecular cell biology 8 (1), 62-72, 2016
702016
The structural organization of substrate loading in iterative polyketide synthases
DA Herbst, CR Huitt-Roehl, RP Jakob, JM Kravetz, PA Storm, JR Alley, ...
Nature chemical biology 14 (5), 474-479, 2018
572018
Computational identification of a systemic antibiotic for gram-negative bacteria
RD Miller, A Iinishi, SM Modaresi, BK Yoo, TD Curtis, PJ Lariviere, L Liang, ...
Nature microbiology 7 (10), 1661-1672, 2022
552022
The tyrosine gate of the bacterial lectin FimH: a conformational analysis by NMR spectroscopy and X‐ray crystallography
B Fiege, S Rabbani, RC Preston, RP Jakob, P Zihlmann, O Schwardt, ...
ChemBioChem 16 (8), 1235-1246, 2015
532015
The prolyl isomerase domain of PpiD from Escherichia coli shows a parvulin fold but is devoid of catalytic activity
U Weininger, RP Jakob, M Kovermann, J Balbach, FX Schmid
Protein Science 19 (1), 6-18, 2010
522010
Energetic coupling between native-state prolyl isomerization and conformational protein folding
RP Jakob, FX Schmid
Journal of molecular biology 377 (5), 1560-1575, 2008
502008
Dimeric structure of the bacterial extracellular foldase PrsA
RP Jakob, JR Koch, BM Burmann, PAM Schmidpeter, M Hunkeler, ...
Journal of Biological Chemistry 290 (6), 3278-3292, 2015
472015
The dynamic mechanism of 4E-BP1 recognition and phosphorylation by mTORC1
R Böhm, S Imseng, RP Jakob, MN Hall, T Maier, S Hiller
Molecular cell 81 (11), 2403-2416. e5, 2021
462021
Evolutionary origins of the multienzyme architecture of giant fungal fatty acid synthase
HST Bukhari, RP Jakob, T Maier
Structure 22 (12), 1775-1785, 2014
452014
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