| Enforced Helicity: Efficient Access to Self‐Organized Helical Molecular Strands by the Imine Route KM Gardinier, RG Khoury, JM Lehn Chemistry–A European Journal 6 (22), 4124-4131, 2000 | 100 | 2000 |
| New chemical modalities and strategic thinking in early drug discovery MJ Blanco, KM Gardinier ACS medicinal chemistry letters 11 (3), 228-231, 2020 | 84 | 2020 |
| Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism AS Kato, KD Burris, KM Gardinier, DL Gernert, WJ Porter, J Reel, C Ding, ... Nature medicine 22 (12), 1496-1501, 2016 | 82 | 2016 |
| Perampanel, an antagonist of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, for the treatment of epilepsy: studies in human epileptic brain and nonepileptic … R Zwart, E Sher, X Ping, X Jin, JR Sims, AS Chappell, SD Gleason, ... Journal of Pharmacology and Experimental Therapeutics 351 (1), 124-133, 2014 | 77 | 2014 |
| Enantiospecific total synthesis of the potent antitumor macrolides cryptophycins 1 and 8 KM Gardinier, JW Leahy The Journal of Organic Chemistry 62 (21), 7098-7099, 1997 | 74 | 1997 |
| Janus molecules: Synthesis of double-headed heterocycles containing two identical hydrogen bonding arrays A Marsh, EG Nolen, KM Gardinier, JM Lehn Tetrahedron letters 35 (3), 397-400, 1994 | 61 | 1994 |
| Discovery of the first α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8 KM Gardinier, DL Gernert, WJ Porter, JK Reel, PL Ornstein, P Spinazze, ... Journal of medicinal chemistry 59 (10), 4753-4768, 2016 | 56 | 2016 |
| Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1 … J Hao, JP Beck, JM Schaus, JH Krushinski, Q Chen, CD Beadle, P Vidal, ... Journal of Medicinal Chemistry 62 (19), 8711-8732, 2019 | 49 | 2019 |
| Radiolabeling of a high potency cannabinoid subtype‐1 receptor ligand, N‐(4‐fluoro‐benzyl)‐4‐(3‐(piperidin‐1‐yl)‐indole‐1‐sulfonyl)benzamide (PipISB), with … SR Donohue, C Halldin, M Schou, J Hong, L Phebus, E Chernet, ... Journal of Labelled Compounds and Radiopharmaceuticals: The Official Journal …, 2008 | 33 | 2008 |
| Untitled WO Patent 2003091226:A1, 0 | 31* | |
| MCH receptor antagonists MB Arnold, Y Dao, KM Gardinier, DJ Garmene, SJ Green, EJ Hembre, ... US Patent 8,263,772, 2012 | 27 | 2012 |
| Structural determinants of the γ-8 TARP dependent AMPA receptor antagonist MR Lee, KM Gardinier, DL Gernert, DA Schober, RA Wright, H Wang, ... ACS chemical neuroscience 8 (12), 2631-2647, 2017 | 23 | 2017 |
| Tachykinin receptor antagonists AK Amegadzie, KM Gardinier, EJ Hembre, JE Hong, LN Jungheim, ... US Patent 7,179,804, 2007 | 22 | 2007 |
| Reconstitution of synaptic Ion channels from rodent and human brain in Xenopus oocytes: a biochemical and electrophysiological characterization F Mazzo, R Zwart, GM Serratto, KM Gardinier, W Porter, J Reel, G Maraula, ... Journal of neurochemistry 138 (3), 384-396, 2016 | 21 | 2016 |
| Modulation of TARP γ8–Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain KL Knopp, RMA Simmons, W Guo, BL Adams, KM Gardinier, DL Gernert, ... Journal of Pharmacology and Experimental Therapeutics 369 (3), 345-363, 2019 | 17 | 2019 |
| Advancing new chemical modalities into clinical studies MJ Blanco, KM Gardinier, MN Namchuk ACS Medicinal Chemistry Letters 13 (11), 1691-1698, 2022 | 16 | 2022 |
| Electroencephalographic, cognitive, and neurochemical effects of LY3130481 (CERC-611), a selective antagonist of TARP-γ8-associated AMPA receptors JM Witkin, J Li, G Gilmour, SN Mitchell, G Carter, SD Gleason, WF Seidel, ... Neuropharmacology 126, 257-270, 2017 | 15 | 2017 |
| Retinoid X receptor modulators KM Gardinier, DL Gernert, TA Grese, DA Neel, CM Mapes, PY Michellys, ... US Patent 7,348,359, 2008 | 12 | 2008 |
| Triazole derivatives as tachykinin receptor antagonists AK Amegadzie, KM Gardinier, EJ Hembre, JE Hong, LN Jungheim, ... US Patent 7,320,994, 2008 | 12 | 2008 |
| Targeted blockade of TARP-γ8-associated AMPA receptors: anticonvulsant activity with the selective antagonist LY3130481 (CERC-611) JM Witkin, DA Schober, SD Gleason, JT Catlow, WJ Porter, J Reel, X Jin, ... CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS …, 2017 | 11 | 2017 |
