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Jonathan E Gable
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Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1
EG Geier, A Schlessinger, H Fan, JE Gable, JJ Irwin, A Sali, KM Giacomini
Proceedings of the National Academy of Sciences 110 (14), 5480-5485, 2013
2012013
Hydrogen bonding and solvent polarity markers in the UV resonance Raman spectrum of tryptophan: application to membrane proteins
DE Schlamadinger, JE Gable, JE Kim
The Journal of Physical Chemistry B 113 (44), 14769-14778, 2009
782009
Effects of tryptophan microenvironment, soluble domain, and vesicle size on the thermodynamics of membrane protein folding: lessons from the transmembrane protein OmpA
KM Sanchez, JE Gable, DE Schlamadinger, JE Kim
Biochemistry 47 (48), 12844-12852, 2008
502008
Enzyme inhibition by allosteric capture of an inactive conformation
GM Lee, T Shahian, A Baharuddin, JE Gable, CS Craik
Journal of molecular biology 411 (5), 999-1016, 2011
402011
Förster resonance energy transfer and conformational stability of proteins. An advanced biophysical module for physical chemistry students
KM Sanchez, DE Schlamadinger, JE Gable, JE Kim
Journal of chemical education 85 (9), 1253, 2008
322008
Current and potential treatments for ubiquitous but neglected herpesvirus infections
JE Gable, TM Acker, CS Craik
Chemical Reviews 114 (22), 11382-11412, 2014
302014
Fluorescence and UV resonance Raman study of peptide− vesicle interactions of human cathelicidin LL-37 and its F6W and F17W Mutants
JE Gable, DE Schlamadinger, AL Cogen, RL Gallo, JE Kim
Biochemistry 48 (47), 11264-11272, 2009
282009
An artificial intelligence approach to proactively inspire drug discovery with recommendations
SL Rohall, L Auch, J Gable, J Gora, J Jansen, Y Lu, E Martin, ...
Journal of medicinal chemistry 63 (16), 8824-8834, 2020
192020
Allosteric inhibitors, crystallography, and comparative analysis reveal network of coordinated movement across human herpesvirus proteases
TM Acker, JE Gable, MF Bohn, P Jaishankar, MC Thompson, JS Fraser, ...
Journal of the American Chemical Society 139 (34), 11650-11653, 2017
182017
Broad-spectrum allosteric inhibition of herpesvirus proteases
JE Gable, GM Lee, P Jaishankar, BR Hearn, CA Waddling, AR Renslo, ...
Biochemistry 53 (28), 4648-4660, 2014
182014
Fragment‐Based Protein–Protein Interaction Antagonists of a Viral Dimeric Protease
JE Gable, GM Lee, TM Acker, KR Hulce, ER Gonzalez, P Schweigler, ...
ChemMedChem 11 (8), 862-869, 2016
122016
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections
SPS Rao, MK Gould, J Noeske, M Saldivia, RS Jumani, PS Ng, O René, ...
Science 380 (6652), 1349-1356, 2023
112023
Toxins and antimicrobial peptides: Interactions with membranes
DE Schlamadinger, JE Gable, JE Kim
Biosensing II 7397, 114-126, 2009
82009
Discovery of novel quinoline-based proteasome inhibitors for Human African Trypanosomiasis (HAT)
DC Koester, VM Marx, S Williams, J Jiricek, M Dauphinais, O René, ...
Journal of medicinal chemistry 65 (17), 11776-11787, 2022
72022
Factor XIIa inhibitors
AU Rao, BA McKittrick, M Lombardo, JD Hicks, AB McCracken, HD Chu, ...
US Patent 10,875,851, 2020
2020
AI-based recommendations for drug discovery
N Stiefl, E Martin, W Shirley, J Jansen, J Gora, L Auch, S ROHALL, Y Lu, ...
American Chemical Society SciMeetings 1 (2), 2020
2020
DRUG DISCOVERY EFFORTS AND DEVELOPMENT OF KINETO-PLASTID ASSAYS AT NOVARTIS INSTITUTES FOR TROPICAL DISEASES
L Pei, SM Concepcion, H Cheung, YL Chen, S Rao, S Williams, J Gable, ...
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE 113, S90-S90, 2019
2019
Allosteric inhibition via two-step enzyme isomerization of human herpesvirus protease protein-protein interaction decreases viral infectivity of Kaposi's sarcoma-associated …
T Acker, J Gable, M Bohn, P Jaishankar, A Renslo, C Craik
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 253, 2017
2017
Developing protein-protein interaction inhibitors of the herpesvirus protease family
JE Gable
UCSF, 2015
2015
Broad-spectrum allosteric inhibition of herpesvirus proteases
C Craik, A Renslo, JE Gable, GM Lee, P Jaishankar, BR Hearn, ...
2014
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Articles 1–20