Janel Kopp
Janel Kopp
Assistant Professor, Department of Cellular & Physiological Sciences, Life Sciences Institute
Verified email at - Homepage
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Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
JL Kopp, G von Figura, E Mayes, FF Liu, CL Dubois, JP Morris, FC Pan, ...
Cancer cell 22 (6), 737-750, 2012
Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
JL Kopp, CL Dubois, AE Schaffer, E Hao, HP Shih, PA Seymour, J Ma, ...
Development 138 (4), 653-665, 2011
Hybrid periportal hepatocytes regenerate the injured liver without giving rise to cancer
J Font-Burgada, S Shalapour, S Ramaswamy, B Hsueh, D Rossell, ...
Cell 162 (4), 766-779, 2015
Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells
JL Kopp, BD Ormsbee, M Desler, A Rizzino
Stem cells 26 (4), 903-911, 2008
Embryonic ductal plate cells give rise to cholangiocytes, periportal hepatocytes, and adult liver progenitor cells
R Carpentier, RE Su˝er, N Van Hul, JL Kopp, JB Beaudry, S Cordi, ...
Gastroenterology 141 (4), 1432-1438. e4, 2011
Sox9 plays multiple roles in the lung epithelium during branching morphogenesis
BE Rockich, SM Hrycaj, HP Shih, MS Nagy, MAH Ferguson, JL Kopp, ...
Proceedings of the National Academy of Sciences 110 (47), E4456-E4464, 2013
Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice
C Dorrell, L Erker, J Schug, JL Kopp, PS Canaday, AJ Fox, O Smirnova, ...
Genes & development 25 (11), 1193-1203, 2011
A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation
HP Shih, JL Kopp, M Sandhu, CL Dubois, PA Seymour, A Grapin-Botton, ...
Development 139 (14), 2488-2499, 2012
Stem cells versus plasticity in liver and pancreas regeneration
JL Kopp, M Grompe, M Sander
Nature cell biology 18 (3), 238-245, 2016
Elevating the levels of Sox2 in embryonal carcinoma cells and embryonic stem cells inhibits the expression of Sox2: Oct-3/4 target genes
B Boer, J Kopp, S Mallanna, M Desler, H Chakravarthy, PJ Wilder, ...
Nucleic acids research 35 (6), 1773-1786, 2007
Hnf1b controls pancreas morphogenesis and the generation of Ngn3+ endocrine progenitors
MG De Vas, JL Kopp, C Heliot, M Sander, S Cereghini, C Haumaitre
Development 142 (5), 871-882, 2015
Hyperinsulinemia in obesity, inflammation, and cancer
AMY Zhang, EA Wellberg, JL Kopp, JD Johnson
Diabetes & metabolism journal 45 (3), 285, 2021
Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma
RG Fox, NK Lytle, DV Jaquish, FD Park, T Ito, J Bajaj, CS Koechlein, ...
Nature 534 (7607), 407-411, 2016
Cell of origin affects tumour development and phenotype in pancreatic ductal adenocarcinoma
AYL Lee, CL Dubois, K Sarai, S Zarei, DF Schaeffer, M Sander, JL Kopp
Gut 68 (3), 487-498, 2019
Progenitor cell domains in the developing and adult pancreas
JL Kopp, CL Dubois, E Hao, F Thorel, PL Herrera, M Sander
Cell cycle 10 (12), 1921-1927, 2011
Sox9 and Sox8 protect the adult testis from male-to-female genetic reprogramming and complete degeneration
FJ Barrionuevo, A Hurtado, GJ Kim, FM Real, M Bakkali, JL Kopp, ...
Elife 5, e15635, 2016
Aggressive PDACs show hypomethylation of repetitive elements and the execution of an intrinsic IFN program linked to a ductal cell of origin
E Espinet, Z Gu, CD Imbusch, NA Giese, M BŘscher, M Safavi, ...
Cancer discovery 11 (3), 638-659, 2021
Loss of Pten and activation of Kras synergistically induce formation of intraductal papillary mucinous neoplasia from pancreatic ductal cells in mice
JL Kopp, CL Dubois, DF Schaeffer, A Samani, F Taghizadeh, RW Cowan, ...
Gastroenterology 154 (5), 1509-1523. e5, 2018
Endogenous hyperinsulinemia contributes to pancreatic cancer development
AMY Zhang, J Magrill, TJJ de Winter, X Hu, S Skovs°, DF Schaeffer, ...
Cell metabolism 30 (3), 403-404, 2019
Unique and selective effects of five Ets family members, Elf3, Ets1, Ets2, PEA3, and PU. 1, on the promoter of the type II transforming growth factor-β receptor gene
JL Kopp, PJ Wilder, M Desler, JH Kim, J Hou, T Nowling, A Rizzino
Journal of Biological Chemistry 279 (19), 19407-19420, 2004
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