| Crystal structure of aspirin-acetylated human cyclooxygenase-2: insight into the formation of products with reversed stereochemistry MJ Lucido, BJ Orlando, AJ Vecchio, MG Malkowski Biochemistry 55 (8), 1226-1238, 2016 | 195 | 2016 |
| Structural basis of fatty acid substrate binding to cyclooxygenase-2 AJ Vecchio, DM Simmons, MG Malkowski Journal of Biological Chemistry 285 (29), 22152-22163, 2010 | 175 | 2010 |
| Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer L Dong, AJ Vecchio, NP Sharma, BJ Jurban, MG Malkowski, WL Smith Journal of Biological Chemistry 286 (21), 19035-19046, 2011 | 120 | 2011 |
| The structural basis of endocannabinoid oxygenation by cyclooxygenase-2 AJ Vecchio, MG Malkowski Journal of Biological Chemistry 286 (23), 20736-20745, 2011 | 56 | 2011 |
| Highlighting membrane protein structure and function: A celebration of the Protein Data Bank F Li, PF Egea, AJ Vecchio, I Asial, M Gupta, J Paulino, R Bajaj, ... Journal of Biological Chemistry 296, 2021 | 54 | 2021 |
| Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove AJ Vecchio, BJ Orlando, R Nandagiri, MG Malkowski Journal of Biological Chemistry 287 (29), 24619-24630, 2012 | 52 | 2012 |
| Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown AJ Vecchio, RM Stroud Proceedings of the National Academy of Sciences 116 (36), 17817-17824, 2019 | 50 | 2019 |
| The structure of NS-398 bound to cyclooxygenase-2 AJ Vecchio, MG Malkowski Journal of structural biology 176 (2), 254-258, 2011 | 37 | 2011 |
| Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut AJ Vecchio, SS Rathnayake, RM Stroud Proceedings of the National Academy of Sciences 118 (15), e2024651118, 2021 | 24 | 2021 |
| Claudin-1-targeted nanoparticles for delivery to aging-induced alterations in the blood–brain barrier BA Bony, AW Tarudji, HA Miller, S Gowrikumar, S Roy, ET Curtis, CC Gee, ... Acs Nano 15 (11), 18520-18531, 2021 | 16 | 2021 |
| Disruption of Claudin-Made Tight Junction Barriers by Clostridium perfringens Enterotoxin: Insights from Structural Biology CP Ogbu, S Roy, AJ Vecchio Cells 11 (5), 903, 2022 | 10 | 2022 |
| Identification and characterization of a first-generation inhibitor of claudin-1 in colon cancer progression and metastasis I Fatima, JP Uppada, YS Chhonker, S Gowrikumar, S Barman, S Roy, ... Biomedicine & Pharmacotherapy 159, 114255, 2023 | 7 | 2023 |
| Claudin-1 interacts with EPHA2 to promote cancer stemness and chemoresistance in colorectal cancer M Primeaux, X Liu, S Gowrikumar, I Fatima, KW Fisher, D Bastola, ... Cancer Letters 579, 216479, 2023 | 6 | 2023 |
| Computational design of soluble functional analogues of integral membrane proteins CA Goverde, M Pacesa, N Goldbach, LJ Dornfeld, PEM Balbi, ... bioRxiv, 2023.05. 09.540044, 2023 | 5 | 2023 |
| Development, structure, and mechanism of synthetic antibodies that target claudin and Clostridium perfringens enterotoxin complexes BJ Orlando, PK Dominik, S Roy, CP Ogbu, SK Erramilli, AA Kossiakoff, ... Journal of Biological Chemistry 298 (9), 2022 | 4 | 2022 |
| Cryo-EM structures of a synthetic antibody against 22 kDa claudin-4 reveal its complex with Clostridium perfringens enterotoxin SK Erramilli, PK Dominik, CP Ogbu, AA Kossiakoff, AJ Vecchio bioRxiv, 2023.06. 12.544689, 2023 | 1 | 2023 |
| Substrates bound to the cyclooxygenase‐2 homodimer exhibit alternate conformations per monomer AJ Vecchio, MG Malkowski The FASEB Journal 25, 551.13-551.13, 2011 | 1 | 2011 |
| Structural basis of Clostridium perfringens enterotoxin activation and oligomerization by trypsin CP Ogbu, S Kapoor, AJ Vecchio Biophysical Journal 123 (3), 346a, 2024 | | 2024 |
| Structural Basis of Clostridium perfringens Enterotoxin Activation and Oligomerization by Trypsin CP Ogbu, S Kapoor, AJ Vecchio Toxins 15 (11), 637, 2023 | | 2023 |
| Identification and characterization of a first-generation inhibitor of claudin-1 to inhibit colon cancer progression and metastasis I Fatima, JP Uppada, YS Chhonker, S Gowrikumar, S Barman, S Roy, ... Cancer Research 83 (7_Supplement), 1590-1590, 2023 | | 2023 |
