Hans-Ulrich Demuth
Hans-Ulrich Demuth
Professor of Protein biotechnology
Verified email at izi.fraunhofer.de - Homepage
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Dipeptidyl peptidase IV inhibitor treatment stimulates β-cell survival and islet neogenesis in streptozotocin-induced diabetic rats
JA Pospisilik, J Martin, T Doty, JA Ehses, N Pamir, FC Lynn, S Piteau, ...
Diabetes 52 (3), 741-750, 2003
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β
JM Nussbaum, S Schilling, H Cynis, A Silva, E Swanson, T Wangsanut, ...
Nature 485 (7400), 651-655, 2012
Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide
RA Pederson, HA White, D Schlenzig, RP Pauly, CHS McIntosh, ...
Diabetes 47 (8), 1253-1258, 1998
The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism
M Engel, T Hoffmann, L Wagner, M Wermann, U Heiser, R Kiefersauer, ...
Proceedings of the National Academy of Sciences 100 (9), 5063-5068, 2003
Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology
S Schilling, U Zeitschel, T Hoffmann, U Heiser, M Francke, A Kehlen, ...
Nature medicine 14 (10), 1106-1111, 2008
Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and β-cell …
JA Pospisilik, SG Stafford, HU Demuth, R Brownsey, W Parkhouse, ...
Diabetes 51 (4), 943-950, 2002
Type 2 diabetes—therapy with dipeptidyl peptidase IV inhibitors
HU Demuth, CHS McIntosh, RA Pederson
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1751 (1), 33-44, 2005
On the seeding and oligomerization of pGlu-amyloid peptides (in vitro)
S Schilling, T Lauber, M Schaupp, S Manhart, E Scheel, G Böhm, ...
Biochemistry 45 (41), 12393-12399, 2006
Use of dipeptidyl peptidase IV effectors for lowering the blood glucose level in mammals
HU Demuth, F Rosche, J Schmidt, RP Pauly, CHS McIntosh, ...
US Patent 6,303,661, 2001
Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor
C Parthier, M Kleinschmidt, P Neumann, R Rudolph, S Manhart, ...
Proceedings of the National Academy of Sciences 104 (35), 13942-13947, 2007
Dipeptidyl peptidase IV inhibitors: how do they work as new antidiabetic agents?
CHS McIntosh, HU Demuth, JA Pospisilik, R Pederson
Regulatory peptides 128 (2), 159-165, 2005
Glucose-dependent insulinotropic polypeptide promotes β-(INS-1) cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p38 mitogen …
JA Ehses, VR Casilla, T Doty, JA Pospisilik, KD Winter, HU Demuth, ...
Endocrinology 144 (10), 4433-4445, 2003
Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1
SA Hinke, K Kühn-Wache, T Hoffmann, RA Pederson, CHS McIntosh, ...
Biochemical and biophysical research communications 291 (5), 1302-1308, 2002
The role of dipeptidyl peptidase IV in human T lymphocyte activation. Inhibitors and antibodies against dipeptidyl peptidase IV suppress lymphocyte proliferation and …
E Schön, S Jahn, ST Kiessig, HU Demuth, K Neubert, A Barth, ...
European journal of immunology 17 (12), 1821-1826, 1987
Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides
D Schlenzig, S Manhart, Y Cinar, M Kleinschmidt, G Hause, D Willbold, ...
Biochemistry 48 (29), 7072-7078, 2009
Investigation of glucose-dependent insulinotropic polypeptide (1-42) and glucagon-like peptide-1-(7-36) degradation in vitro by dipeptidyl peptidase IV using matrix-assisted …
RP Pauly, F Rosche, M Wermann, CHS McIntosh, RA Pederson, ...
Journal of Biological Chemistry 271 (38), 23222-23229, 1996
Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study
JA Pospisilik, SG Stafford, HU Demuth, CHS McIntosh, RA Pederson
Diabetes 51 (9), 2677-2683, 2002
Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model
O Wirths, H Breyhan, H Cynis, S Schilling, HU Demuth, TA Bayer
Acta neuropathologica 118 (4), 487-496, 2009
Effectors of dipeptidyl peptidase IV
HU Demuth, K Glund, D Schlenzig, S Kruber
US Patent 6,548,481, 2003
Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions
S Schilling, T Hoffmann, S Manhart, M Hoffmann, HU Demuth
FEBS letters 563 (1-3), 191-196, 2004
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