| Endoplasmic reticulum dysfunction in neurological disease BD Roussel, AJ Kruppa, E Miranda, DC Crowther, DA Lomas, ... The Lancet Neurology 12 (1), 105-118, 2013 | 465 | 2013 |
| Intraneuronal Aβ, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer’s disease DC Crowther, KJ Kinghorn, E Miranda, R Page, JA Curry, FAI Duthie, ... Neuroscience 132 (1), 123-135, 2005 | 433 | 2005 |
| ANS binding reveals common features of cytotoxic amyloid species B Bolognesi, JR Kumita, TP Barros, EK Esbjorner, LM Luheshi, ... ACS chemical biology 5 (8), 735-740, 2010 | 410 | 2010 |
| Iron promotes the toxicity of amyloid β peptide by impeding its ordered aggregation B Liu, A Moloney, S Meehan, K Morris, SE Thomas, LC Serpell, R Hider, ... Journal of Biological Chemistry 286 (6), 4248-4256, 2011 | 253 | 2011 |
| Protein misfolding and disease: from the test tube to the organism LM Luheshi, DC Crowther, CM Dobson Current opinion in chemical biology 12 (1), 25-31, 2008 | 221 | 2008 |
| Systematic in vivo analysis of the intrinsic determinants of amyloid β pathogenicity LM Luheshi, GG Tartaglia, AC Brorsson, AP Pawar, IE Watson, F Chiti, ... PLoS biology 5 (11), e290, 2007 | 220 | 2007 |
| Fenton chemistry and oxidative stress mediate the toxicity of the β‐amyloid peptide in a Drosophila model of Alzheimer’s disease T Rival, RM Page, DS Chandraratna, TJ Sendall, E Ryder, B Liu, H Lewis, ... European Journal of Neuroscience 29 (7), 1335-1347, 2009 | 199 | 2009 |
| α-Helix targeting reduces amyloid-β peptide toxicity C Nerelius, A Sandegren, H Sargsyan, R Raunak, H Leijonmarck, ... Proceedings of the National Academy of Sciences 106 (23), 9191-9196, 2009 | 171 | 2009 |
| Alzheimer's disease: insights from Drosophila melanogaster models A Moloney, DB Sattelle, DA Lomas, DC Crowther Trends in biochemical sciences 35 (4), 228-235, 2010 | 149 | 2010 |
| Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins H Kroeger, E Miranda, I MacLeod, J Perez, DC Crowther, SJ Marciniak, ... Journal of Biological Chemistry 284 (34), 22793-22802, 2009 | 147 | 2009 |
| Plasma and CSF serpins in Alzheimer disease and dementia with Lewy bodies HM Nielsen, L Minthon, E Londos, K Blennow, E Miranda, J Perez, ... Neurology 69 (16), 1569-1579, 2007 | 140 | 2007 |
| TREM 2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant P Thornton, J Sevalle, MJ Deery, G Fraser, Y Zhou, S Ståhl, EH Franssen, ... EMBO molecular medicine 9 (10), 1366-1378, 2017 | 133 | 2017 |
| CCT complex restricts neuropathogenic protein aggregation via autophagy M Pavel, S Imarisio, FM Menzies, M Jimenez-Sanchez, FH Siddiqi, X Wu, ... Nature communications 7 (1), 13821, 2016 | 125 | 2016 |
| ALS mutations in FUS cause neuronal dysfunction and death in Caenorhabditis elegans by a dominant gain-of-function mechanism T Murakami, SP Yang, L Xie, T Kawano, D Fu, A Mukai, C Bohm, F Chen, ... Human molecular genetics 21 (1), 1-9, 2012 | 124 | 2012 |
| The intracellular accumulation of polymeric neuroserpin explains the severity of the dementia FENIB E Miranda, I MacLeod, MJ Davies, J Pérez, K Römisch, DC Crowther, ... Human molecular genetics 17 (11), 1527-1539, 2008 | 104 | 2008 |
| Neuroserpin binds Aβ and is a neuroprotective component of amyloid plaques in Alzheimer disease KJ Kinghorn, DC Crowther, LK Sharp, C Nerelius, RL Davis, HT Chang, ... Journal of biological chemistry 281 (39), 29268-29277, 2006 | 98 | 2006 |
| Sequestration of the Aβ peptide prevents toxicity and promotes degradation in vivo LM Luheshi, W Hoyer, TP de Barros, I van Dijk Härd, AC Brorsson, ... PLoS biology 8 (3), e1000334, 2010 | 94 | 2010 |
| Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease R Costa, E Speretta, DC Crowther, I Cardoso Journal of Biological Chemistry 286 (48), 41647-41655, 2011 | 88 | 2011 |
| Practical genetics: alpha-1-antitrypsin deficiency and the serpinopathies DC Crowther, D Belorgey, E Miranda, KJ Kinghorn, LK Sharp, DA Lomas European journal of human genetics 12 (3), 167-172, 2004 | 88 | 2004 |
| Mutant neuroserpin (S49P) that causes familial encephalopathy with neuroserpin inclusion bodies is a poor proteinase inhibitor and readily forms polymers in vitro D Belorgey, DC Crowther, R Mahadeva, DA Lomas Journal of Biological Chemistry 277 (19), 17367-17373, 2002 | 82 | 2002 |
