Susanne Wegmann
Susanne Wegmann
Group Leader at DZNE Berlin
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Tau protein liquid–liquid phase separation can initiate tau aggregation
S Wegmann, B Eftekharzadeh, K Tepper, KM Zoltowska, RE Bennett, ...
The EMBO journal 37 (7), e98049, 2018
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain
S Takeda, S Wegmann, H Cho, SL DeVos, C Commins, AD Roe, ...
Nature communications 6 (1), 1-15, 2015
Tau protein disrupts nucleocytoplasmic transport in Alzheimer’s disease
B Eftekharzadeh, JG Daigle, LE Kapinos, A Coyne, J Schiantarelli, ...
Neuron 99 (5), 925-940. e7, 2018
Local nucleation of microtubule bundles through tubulin concentration into a condensed tau phase
A Hernández-Vega, M Braun, L Scharrel, M Jahnel, S Wegmann, ...
Cell reports 20 (10), 2304-2312, 2017
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo
MA Busche, S Wegmann, S Dujardin, C Commins, J Schiantarelli, ...
Nature neuroscience 22 (1), 57-64, 2019
LRP1 is a master regulator of tau uptake and spread
JN Rauch, G Luna, E Guzman, M Audouard, C Challis, YE Sibih, ...
Nature 580 (7803), 381-385, 2020
Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease
AM Pooler, M Polydoro, EA Maury, SB Nicholls, SM Reddy, S Wegmann, ...
Acta neuropathologica communications 3 (1), 1-11, 2015
Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo
KV Kuchibhotla, S Wegmann, KJ Kopeikina, J Hawkes, N Rudinskiy, ...
Proceedings of the National Academy of Sciences 111 (1), 510-514, 2014
The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush
S Wegmann, ID Medalsy, E Mandelkow, DJ Müller
Proceedings of the National Academy of Sciences 110 (4), E313-E321, 2013
Atypical, non-standard functions of the microtubule associated Tau protein
I Sotiropoulos, MC Galas, JM Silva, E Skoulakis, S Wegmann, MB Maina, ...
Acta neuropathologica communications 5 (1), 1-11, 2017
Oligomer formation of tau protein hyperphosphorylated in cells
K Tepper, J Biernat, S Kumar, S Wegmann, T Timm, S Hübschmann, ...
Journal of Biological Chemistry 289 (49), 34389-34407, 2014
Multiparametric high-resolution imaging of native proteins by force-distance curve–based AFM
M Pfreundschuh, D Martinez-Martin, E Mulvihill, S Wegmann, DJ Muller
nature protocols 9 (5), 1113-1130, 2014
Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability
S Wegmann, YJ Jung, S Chinnathambi, EM Mandelkow, E Mandelkow, ...
Journal of Biological Chemistry 285 (35), 27302-27313, 2010
Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity
S Wegmann, EA Maury, MJ Kirk, L Saqran, A Roe, SL DeVos, S Nicholls, ...
The EMBO journal 34 (24), 3028-3041, 2015
Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets
AM Pooler, M Polydoro, S Wegmann, SB Nicholls, TL Spires-Jones, ...
Alzheimer's research & therapy 5 (5), 1-8, 2013
Tau antibody targeting pathological species blocks neuronal uptake and interneuron propagation of tau in vitro
CK Nobuhara, SL DeVos, C Commins, S Wegmann, BD Moore, AD Roe, ...
The American journal of pathology 187 (6), 1399-1412, 2017
Seed‐competent high‐molecular‐weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients
S Takeda, C Commins, SL DeVos, CK Nobuhara, S Wegmann, AD Roe, ...
Annals of neurology 80 (3), 355-367, 2016
Human tau increases amyloid β plaque size but not amyloid β‐mediated synapse loss in a novel mouse model of Alzheimer's disease
RJ Jackson, N Rudinskiy, AG Herrmann, S Croft, JSM Kim, V Petrova, ...
European Journal of Neuroscience 44 (12), 3056-3066, 2016
Experimental evidence for the age dependence of tau protein spread in the brain
S Wegmann, RE Bennett, L Delorme, AB Robbins, M Hu, D MacKenzie, ...
Science advances 5 (6), eaaw6404, 2019
Stages and conformations of the Tau repeat domain during aggregation and its effect on neuronal toxicity
S Kumar, K Tepper, S Kaniyappan, J Biernat, S Wegmann, ...
Journal of biological chemistry 289 (29), 20318-20332, 2014
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