David N. Frick
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The MutT proteins or “Nudix” hydrolases, a family of versatile, widely distributed,“housecleaning” enzymes
MJ Bessman, DN Frick, SF O'Handley
Journal of Biological Chemistry 271 (41), 25059-25062, 1996
DNA primases
DN Frick, CC Richardson
Annual review of biochemistry 70 (1), 39-80, 2001
Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug
E Mastrangelo, M Pezzullo, T De Burghgraeve, S Kaptein, B Pastorino, ...
Journal of Antimicrobial Chemotherapy 67 (8), 1884-1894, 2012
PSI-7851, a pronucleotide of β-D-2′-deoxy-2′-fluoro-2′-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication
AM Lam, E Murakami, C Espiritu, HMM Steuer, C Niu, M Keilman, H Bao, ...
Antimicrobial agents and chemotherapy 54 (8), 3187-3196, 2010
Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase
AMI Lam, DN Frick
Journal of virology 80 (1), 404-411, 2006
Studies on the ADP-ribose pyrophosphatase subfamily of the nudix hydrolases and tentative identification of trgB, a gene associated with tellurite resistance
CA Dunn, SF O'Handley, DN Frick, MJ Bessman
Journal of Biological Chemistry 274 (45), 32318-32324, 1999
The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target
DN Frick
Current issues in molecular biology 9 (1), 1, 2007
The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently
DN Frick, RS Rypma, AMI Lam, B Gu
Journal of Biological Chemistry 279 (2), 1269-1280, 2004
Development of novel therapies for hepatitis C
SM Lemon, JA McKeating, T Pietschmann, DN Frick, JS Glenn, ...
Antiviral research 86 (1), 79-92, 2010
Solution structure of the MutT enzyme, a nucleoside triphosphate pyrophosphohydrolase
C Abeygunawardana, DJ Weber, AG Gittis, DN Frick, J Lin, AF Miller, ...
Biochemistry 34 (46), 14997-15005, 1995
Cloning, purification, and properties of a novel NADH pyrophosphatase: evidence for a nucleotide pyrophosphatase catalytic domain in MutT-like enzymes
DN Frick, MJ Bessman
Journal of Biological Chemistry 270 (4), 1529-1534, 1995
Solution Structure of the Quaternary MutT−M2+−AMPCPP−M2+ Complex and Mechanism of Its Pyrophosphohydrolase Action,
J Lin, C Abeygunawardana, DN Frick, MJ Bessman, AS Mildvan
Biochemistry 36 (6), 1199-1211, 1997
Orf186 represents a new member of the Nudix hydrolases, active on adenosine (5′) triphospho (5′) adenosine, ADP-ribose, and NADH
SF O'Handley, DN Frick, CA Dunn, MJ Bessman
Journal of Biological Chemistry 273 (6), 3192-3197, 1998
A novel GDP-mannose mannosyl hydrolase shares homology with the MutT family of enzymes
DN Frick, BD Townsend, MJ Bessman
Journal of Biological Chemistry 270 (41), 24086-24091, 1995
Understanding helicases as a means of virus control
DN Frick, AMI Lam
Current pharmaceutical design 12 (11), 1315-1338, 2006
Discovering new medicines targeting helicases: challenges and recent progress
WR Shadrick, J Ndjomou, R Kolli, S Mukherjee, AM Hanson, DN Frick
Journal of biomolecular screening 18 (7), 761-781, 2013
Hepatitis C virus NS3 ATPases/helicases from different genotypes exhibit variations in enzymatic properties
AMI Lam, D Keeney, PQ Eckert, DN Frick
Journal of virology 77 (7), 3950-3961, 2003
An N-terminal fragment of the gene 4 helicase/primase of bacteriophage T7 retains primase activity in the absence of helicase activity
DN Frick, K Baradaran, CC Richardson
Proceedings of the National Academy of Sciences 95 (14), 7957-7962, 1998
DNA damage alters DNA polymerase δ to a form that exhibits increased discrimination against modified template bases and mismatched primers
X Meng, Y Zhou, S Zhang, EYC Lee, DN Frick, MYWT Lee
Nucleic acids research 37 (2), 647-657, 2009
Two novel conserved motifs in the hepatitis C virus NS3 protein critical for helicase action
AMI Lam, D Keeney, DN Frick
Journal of Biological Chemistry 278 (45), 44514-44524, 2003
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