| Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex S Konermann, MD Brigham, AE Trevino, J Joung, OO Abudayyeh, ... Nature 517 (7536), 583-588, 2015 | 2870 | 2015 |
| Crystal structure of Cas9 in complex with guide RNA and target DNA H Nishimasu, FA Ran, PD Hsu, S Konermann, SI Shehata, N Dohmae, ... Cell 156 (5), 935-949, 2014 | 2300 | 2014 |
| Engineered CRISPR-Cas9 nuclease with expanded targeting space H Nishimasu, X Shi, S Ishiguro, L Gao, S Hirano, S Okazaki, T Noda, ... Science 361 (6408), 1259-1262, 2018 | 980 | 2018 |
| Crystal structure of Cpf1 in complex with guide RNA and target DNA T Yamano, H Nishimasu, B Zetsche, H Hirano, IM Slaymaker, Y Li, ... Cell 165 (4), 949-962, 2016 | 679 | 2016 |
| Crystal structure of Staphylococcus aureus Cas9 H Nishimasu, L Cong, WX Yan, FA Ran, B Zetsche, Y Li, A Kurabayashi, ... Cell 162 (5), 1113-1126, 2015 | 474 | 2015 |
| Engineered Cpf1 variants with altered PAM specificities L Gao, DBT Cox, WX Yan, JC Manteiga, MW Schneider, T Yamano, ... Nature biotechnology 35 (8), 789-792, 2017 | 449 | 2017 |
| Structure and function of Zucchini endoribonuclease in piRNA biogenesis H Nishimasu, H Ishizu, K Saito, S Fukuhara, MK Kamatani, L Bonnefond, ... Nature 491 (7423), 284-287, 2012 | 384 | 2012 |
| Structure and engineering of Francisella novicida Cas9 H Hirano, JS Gootenberg, T Horii, OO Abudayyeh, M Kimura, PD Hsu, ... Cell 164 (5), 950-961, 2016 | 377 | 2016 |
| Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase S Akichika, S Hirano, Y Shichino, T Suzuki, H Nishimasu, R Ishitani, ... Science 363 (6423), eaav0080, 2019 | 299 | 2019 |
| Crystal structure of autotaxin and insight into GPCR activation by lipid mediators H Nishimasu, S Okudaira, K Hama, E Mihara, N Dohmae, A Inoue, ... Nature structural & molecular biology 18 (2), 205-212, 2011 | 281 | 2011 |
| Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF‐κB regulation F Tokunaga, H Nishimasu, R Ishitani, E Goto, T Noguchi, K Mio, K Kamei, ... The EMBO journal 31 (19), 3856-3870, 2012 | 233 | 2012 |
| Structural basis for the canonical and non-canonical PAM recognition by CRISPR-Cpf1 T Yamano, B Zetsche, R Ishitani, F Zhang, H Nishimasu, O Nureki Molecular cell 67 (4), 633-645. e3, 2017 | 216 | 2017 |
| Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy M Shibata, H Nishimasu, N Kodera, S Hirano, T Ando, T Uchihashi, ... Nature communications 8 (1), 1430, 2017 | 215 | 2017 |
| Genome editing in plants by engineered CRISPR–Cas9 recognizing NG PAM M Endo, M Mikami, A Endo, H Kaya, T Itoh, H Nishimasu, O Nureki, S Toki Nature plants 5 (1), 14-17, 2019 | 175 | 2019 |
| Crystal structure of the minimal Cas9 from Campylobacter jejuni reveals the molecular diversity in the CRISPR-Cas9 systems M Yamada, Y Watanabe, JS Gootenberg, H Hirano, FA Ran, T Nakane, ... Molecular cell 65 (6), 1109-1121. e3, 2017 | 175 | 2017 |
| Structural basis for the altered PAM specificities of engineered CRISPR-Cas9 S Hirano, H Nishimasu, R Ishitani, O Nureki Molecular cell 61 (6), 886-894, 2016 | 171 | 2016 |
| Base editors for simultaneous introduction of C-to-T and A-to-G mutations RC Sakata, S Ishiguro, H Mori, M Tanaka, K Tatsuno, H Ueda, ... Nature biotechnology 38 (7), 865-869, 2020 | 168 | 2020 |
| Crystal structure of silkworm PIWI-clade Argonaute Siwi bound to piRNA N Matsumoto, H Nishimasu, K Sakakibara, KM Nishida, T Hirano, ... Cell 167 (2), 484-497. e9, 2016 | 142 | 2016 |
| Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling K Kato, H Nishimasu, S Okudaira, E Mihara, R Ishitani, J Takagi, J Aoki, ... Proceedings of the National Academy of Sciences 109 (42), 16876-16881, 2012 | 137 | 2012 |
| Amplification-free RNA detection with CRISPR–Cas13 H Shinoda, Y Taguchi, R Nakagawa, A Makino, S Okazaki, M Nakano, ... Communications biology 4 (1), 476, 2021 | 129 | 2021 |
