| Familial Alzheimer's disease–linked presenilin 1 variants elevate Aβ1–42/1–40 ratio in vitro and in vivo DR Borchelt, G Thinakaran, CB Eckman, MK Lee, F Davenport, ... Neuron 17 (5), 1005-1013, 1996 | 2087 | 1996 |
| APP processing and synaptic function F Kamenetz, T Tomita, H Hsieh, G Seabrook, D Borchelt, T Iwatsubo, ... Neuron 37 (6), 925-937, 2003 | 2063 | 2003 |
| An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria PC Wong, CA Pardo, DR Borchelt, MK Lee, NG Copeland, NA Jenkins, ... Neuron 14 (6), 1105-1116, 1995 | 1745 | 1995 |
| Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase JL Jankowsky, DJ Fadale, J Anderson, GM Xu, V Gonzales, NA Jenkins, ... Human molecular genetics 13 (2), 159-170, 2004 | 1727 | 2004 |
| ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions LI Bruijn, MW Becher, MK Lee, KL Anderson, NA Jenkins, NG Copeland, ... Neuron 18 (2), 327-338, 1997 | 1608 | 1997 |
| BACE1 is the major β-secretase for generation of Aβ peptides by neurons H Cai, Y Wang, D McCarthy, H Wen, DR Borchelt, DL Price, PC Wong Nature neuroscience 4 (3), 233-234, 2001 | 1458 | 2001 |
| Scrapie prion protein contains a phosphatidylinositol glycolipid N Stahl, DR Borchelt, K Hsiao, SB Prusiner Cell 51 (2), 229-240, 1987 | 1410 | 1987 |
| Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo G Thinakaran, DR Borchelt, MK Lee, HH Slunt, L Spitzer, G Kim, ... Neuron 17 (1), 181-190, 1996 | 1340 | 1996 |
| Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins DR Borchelt, T Ratovitski, J Van Lare, MK Lee, V Gonzales, NA Jenkins, ... Neuron 19 (4), 939-945, 1997 | 1328 | 1997 |
| Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide D Krewski, RA Yokel, E Nieboer, D Borchelt, J Cohen, J Harry, S Kacew, ... Journal of Toxicology and Environmental Health, Part B 10 (S1), 1-269, 2007 | 1199 | 2007 |
| Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin G Schilling, MW Becher, AH Sharp, HA Jinnah, K Duan, JA Kotzuk, ... Human molecular genetics 8 (3), 397-407, 1999 | 914 | 1999 |
| Co-expression of multiple transgenes in mouse CNS: a comparison of strategies JL Jankowsky, HH Slunt, T Ratovitski, NA Jenkins, NG Copeland, ... Biomolecular engineering 17 (6), 157-165, 2001 | 876 | 2001 |
| Decreased expression of striatal signaling genes in a mouse model of Huntington’s disease R Luthi-Carter, A Strand, NL Peters, SM Solano, ZR Hollingsworth, ... Human molecular genetics 9 (9), 1259-1271, 2000 | 848 | 2000 |
| Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. DR Borchelt, MK Lee, HS Slunt, M Guarnieri, ZS Xu, PC Wong, ... Proceedings of the National Academy of Sciences 91 (17), 8292-8296, 1994 | 788 | 1994 |
| Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells. DR Borchelt, M Scott, A Taraboulos, N Stahl, SB Prusiner The Journal of cell biology 110 (3), 743-752, 1990 | 684 | 1990 |
| BACE1, a major determinant of selective vulnerability of the brain to amyloid-β amyloidogenesis, is essential for cognitive, emotional, and synaptic functions FM Laird, H Cai, AV Savonenko, MH Farah, K He, T Melnikova, H Wen, ... Journal of Neuroscience 25 (50), 11693-11709, 2005 | 675 | 2005 |
| Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins KK Hsiao, DR Borchelt, K Olson, R Johannsdottir, C Kitt, W Yunis, S Xu, ... Neuron 15 (5), 1203-1218, 1995 | 675 | 1995 |
| Evidence for synthesis of scrapie prion proteins in the endocytic pathway. DR Borchelt, A Taraboulos, SB Prusiner Journal of Biological Chemistry 267 (23), 16188-16199, 1992 | 643 | 1992 |
| Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease JL Jankowsky, T Melnikova, DJ Fadale, GM Xu, HH Slunt, V Gonzales, ... Journal of Neuroscience 25 (21), 5217-5224, 2005 | 629 | 2005 |
| Alzheimer's disease: genetic studies and transgenic models DL Price, RE Tanzi, DR Borchelt, SS Sisodia Annual review of genetics 32 (1), 461-493, 1998 | 550 | 1998 |
