Jan Krützfeldt
Jan Krützfeldt
University Hospital Zurich
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Silencing of microRNAs in vivo with ‘antagomirs’
J Krützfeldt, N Rajewsky, R Braich, KG Rajeev, T Tuschl, M Manoharan, ...
nature 438 (7068), 685-689, 2005
A pancreatic islet-specific microRNA regulates insulin secretion
MN Poy, L Eliasson, J Krutzfeldt, S Kuwajima, X Ma, PE Macdonald, ...
Nature 432 (7014), 226-230, 2004
Specificity, duplex degradation and subcellular localization of antagomirs
J Krützfeldt, S Kuwajima, R Braich, KG Rajeev, J Pena, T Tuschl, ...
Nucleic acids research 35 (9), 2885-2892, 2007
MicroRNAs: a new class of regulatory genes affecting metabolism
J Krützfeldt, M Stoffel
Cell metabolism 4 (1), 9-12, 2006
Strategies to determine the biological function of microRNAs
J Krützfeldt, MN Poy, M Stoffel
Nature genetics 38 (Suppl 6), S14-S19, 2006
Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice
K Otani, RN Kulkarni, AC Baldwin, J Krutzfeldt, K Ueki, M Stoffel, CR Kahn, ...
American journal of physiology-endocrinology and metabolism 286 (1), E41-E49, 2004
Tmem27: A cleaved and shed plasma membrane protein that stimulates pancreatic β cell proliferation
P Akpinar, S Kuwajima, J Krützfeldt, M Stoffel
Cell metabolism 2 (6), 385-397, 2005
Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells
C Kausch, J Krützfeldt, A Witke, A Rettig, O Bachmann, K Rett, S Matthaei, ...
Biochemical and Biophysical Research Communications 280 (3), 664-674, 2001
Insulin signaling and action in cultured skeletal muscle cells from lean healthy humans with high and low insulin sensitivity.
J Krützfeldt, C Kausch, A Volk, HH Klein, K Rett, HU Häring, M Stumvoll
Diabetes 49 (6), 992-998, 2000
Serine residues 994 and 1023/25 are important for insulin receptor kinase inhibition by protein kinase C isoforms β2 and θ
V Strack, AM Hennige, J Krützfeldt, B Bossenmaier, HH Klein, M Kellerer, ...
Diabetologia 43, 443-449, 2000
MicroRNA‐194 is a target of transcription factor 1 (Tcf1, HNF1α) in adult liver and controls expression of frizzled‐6
J Krützfeldt, N Rösch, J Hausser, M Manoharan, M Zavolan, M Stoffel
Hepatology 55 (1), 98-107, 2012
Structure-function relationships of HDL in diabetes and coronary heart disease
M Cardner, M Yalcinkaya, S Goetze, E Luca, M Balaz, M Hunjadi, ...
JCI insight 5 (1), 2020
Strategies to use microRNAs as therapeutic targets
J Krützfeldt
Best practice & research Clinical endocrinology & metabolism 30 (5), 551-561, 2016
MicroRNA-29a in adult muscle stem cells controls skeletal muscle regeneration during injury and exercise downstream of fibroblast growth factor-2
A Galimov, TL Merry, E Luca, EJ Rushing, A Mizbani, K Turcekova, ...
Stem Cells 34 (3), 768-780, 2016
Regulation of wingless-type MMTV integration site family (WNT) signalling in pancreatic islets from wild-type and obese mice
J Krützfeldt, M Stoffel
Diabetologia 53, 123-127, 2010
The protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms α, β1, β2, and η
V Strack, J Krützfeldt, M Kellerer, A Ullrich, R Lammers, HU Häring
Biochemistry 41 (2), 603-608, 2002
Uncoupling protein 1 expression in adipocytes derived from skeletal muscle fibro/adipogenic progenitors is under genetic and hormonal control
T Gorski, S Mathes, J Krützfeldt
Journal of cachexia, sarcopenia and muscle 9 (2), 384-399, 2018
Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation.
B Bossenmaier, V Strack, B Stoyanov, J Krützfeldt, A Beck, R Lehmann, ...
Diabetes 49 (6), 889-895, 2000
FGF-2–dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis
S Mathes, A Fahrner, U Ghoshdastider, HA Rüdiger, M Leunig, C Wolfrum, ...
Proceedings of the National Academy of Sciences 118 (37), e2021013118, 2021
Growth hormone replacement therapy regulates microRNA-29a and targets involved in insulin resistance
A Galimov, A Hartung, R Trepp, A Mader, M Flück, A Linke, M Blüher, ...
Journal of molecular medicine 93, 1369-1379, 2015
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