|Adverse outcome pathways: opportunities, limitations and open questions|
M Leist, A Ghallab, R Graepel, R Marchan, R Hassan, SH Bennekou, ...
Archives of toxicology 91 (11), 3477-3505, 2017
|The ascending pathophysiology of cholestatic liver disease|
PLM Jansen, A Ghallab, N Vartak, R Reif, FG Schaap, J Hampe, ...
Hepatology 65 (2), 722-738, 2017
|Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases|
A Ghallab, G Cellière, SG Henkel, D Driesch, S Hoehme, U Hofmann, ...
Journal of hepatology 64 (4), 860-871, 2016
|Integrated metabolic spatial‐temporal model for the prediction of ammonia detoxification during liver damage and regeneration|
F Schliess, S Hoehme, SG Henkel, A Ghallab, D Driesch, J Böttger, ...
Hepatology 60 (6), 2040-2051, 2014
|Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue|
P Godoy, A Widera, W Schmidt-Heck, G Campos, C Meyer, C Cadenas, ...
Archives of toxicology 90 (10), 2513-2529, 2016
|A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation|
C Thiel, S Schneckener, M Krauss, A Ghallab, U Hofmann, T Kanacher, ...
Journal of pharmaceutical sciences 104 (1), 191-206, 2015
|The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator …|
G Campos, W Schmidt-Heck, A Ghallab, K Rochlitz, L Pütter, DB Medinas, ...
Archives of toxicology 88 (6), 1267-1280, 2014
|In vitro test systems and their limitations|
EXCLI journal 12, 1024, 2013
|In vitro-in vivo correlation of gene expression alterations induced by liver carcinogens|
T Heise, M Schug, D Storm, H Ellinger-Ziegelbauer, H J Ahr, B Hellwig, ...
Current medicinal chemistry 19 (11), 1721-1730, 2012
|Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood|
A Ghallab, U Hofmann, S Sezgin, N Vartak, R Hassan, A Zaza, P Godoy, ...
Hepatology 69 (2), 666-683, 2019
|Cellular clearance and biological activity of calciprotein particles depend on their maturation state and crystallinity|
S Köppert, A Büscher, A Babler, A Ghallab, EM Buhl, E Latz, JG Hengstler, ...
Frontiers in immunology 9, 1991, 2018
|Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage|
A Schenk, A Ghallab, U Hofmann, R Hassan, M Schwarz, A Schuppert, ...
Scientific reports 7 (1), 1-13, 2017
|In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice|
R Reif, A Ghallab, L Beattie, G Günther, L Kuepfer, PM Kaye, ...
Archives of toxicology 91 (3), 1335-1352, 2017
|Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations|
W Albrecht, F Kappenberg, T Brecklinghaus, R Stoeber, R Marchan, ...
Archives of toxicology 93 (6), 1609-1637, 2019
|The virtual liver: state of the art and future perspectives|
D Drasdo, J Bode, U Dahmen, O Dirsch, S Dooley, R Gebhardt, A Ghallab, ...
Archives of toxicology 88 (12), 2071-2075, 2014
|Optimality in the zonation of ammonia detoxification in rodent liver|
M Bartl, M Pfaff, A Ghallab, D Driesch, SG Henkel, JG Hengstler, ...
Archives of toxicology 89 (11), 2069-2078, 2015
|Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI|
S Sezgin, R Hassan, S Zühlke, L Kuepfer, JG Hengstler, M Spiteller, ...
Archives of toxicology 92 (9), 2963-2977, 2018
|Activated ErbB3 translocates to the nucleus via clathrin-independent endocytosis, which is associated with proliferating cells|
R Reif, A Adawy, N Vartak, J Schröder, G Günther, A Ghallab, M Schmidt, ...
Journal of Biological Chemistry 291 (8), 3837-3847, 2016
|The rediscovery of HepG2 cells for prediction of drug induced liver injury (DILI)|
EXCLI journal 13, 1286, 2014
|Influence of liver fibrosis on lobular zonation|
A Ghallab, M Myllys, C H Holland, A Zaza, W Murad, R Hassan, ...
Cells 8 (12), 1556, 2019