Somatic mutant clones colonize the human esophagus with age I Martincorena, JC Fowler, A Wabik, ARJ Lawson, F Abascal, MWJ Hall, ... Science 362 (6417), 911-917, 2018 | 951 | 2018 |
Great ape genetic diversity and population history J Prado-Martinez, PH Sudmant, JM Kidd, H Li, JL Kelley, ... Nature 499 (7459), 471-475, 2013 | 936 | 2013 |
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors MD Young, TJ Mitchell, FA Vieira Braga, MGB Tran, BJ Stewart, ... science 361 (6402), 594-599, 2018 | 577 | 2018 |
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B. 1.1. 7 B Meng, SA Kemp, G Papa, R Datir, IATM Ferreira, S Marelli, WT Harvey, ... Cell reports 35 (13), 2021 | 425 | 2021 |
Spatiotemporal immune zonation of the human kidney BJ Stewart, JR Ferdinand, MD Young, TJ Mitchell, KW Loudon, AM Riding, ... Science 365 (6460), 1461-1466, 2019 | 318 | 2019 |
Somatic mutation landscapes at single-molecule resolution F Abascal, LMR Harvey, E Mitchell, ARJ Lawson, SV Lensing, P Ellis, ... Nature 593 (7859), 405-410, 2021 | 301 | 2021 |
Evidence of long-term gene flow and selection during domestication from analyses of Eurasian wild and domestic pig genomes LAF Frantz, JG Schraiber, O Madsen, HJ Megens, A Cagan, M Bosse, ... Nature genetics 47 (10), 1141-1148, 2015 | 301 | 2015 |
Somatic mutation rates scale with lifespan across mammals A Cagan, A Baez-Ortega, N Brzozowska, F Abascal, THH Coorens, ... Nature 604 (7906), 517-524, 2022 | 262 | 2022 |
Extensive heterogeneity in somatic mutation and selection in the human bladder ARJ Lawson, F Abascal, THH Coorens, Y Hooks, L O’Neill, C Latimer, ... Science 370 (6512), 75-82, 2020 | 216 | 2020 |
The mutational landscape of human somatic and germline cells L Moore, A Cagan, THH Coorens, MDC Neville, R Sanghvi, MA Sanders, ... Nature 597 (7876), 381-386, 2021 | 215 | 2021 |
Clonal dynamics of haematopoiesis across the human lifespan E Mitchell, M Spencer Chapman, N Williams, KJ Dawson, N Mende, ... Nature 606 (7913), 343-350, 2022 | 195 | 2022 |
Embryonal precursors of Wilms tumor THH Coorens, TD Treger, R Al-Saadi, L Moore, MGB Tran, TJ Mitchell, ... Science 366 (6470), 1247-1251, 2019 | 127 | 2019 |
Extensive phylogenies of human development inferred from somatic mutations THH Coorens, L Moore, PS Robinson, R Sanghvi, J Christopher, ... Nature 597 (7876), 387-392, 2021 | 98 | 2021 |
Reliable detection of somatic mutations in solid tissues by laser-capture microdissection and low-input DNA sequencing P Ellis, L Moore, MA Sanders, TM Butler, SF Brunner, H Lee-Six, ... Nature Protocols 16 (2), 841-871, 2021 | 89 | 2021 |
Epidermal tissue adapts to restrain progenitors carrying clonal p53 mutations K Murai, G Skrupskelyte, G Piedrafita, M Hall, V Kostiou, SH Ong, T Nagy, ... Cell stem cell 23 (5), 687-699. e8, 2018 | 87 | 2018 |
Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids N Georgakopoulos, N Prior, B Angres, G Mastrogiovanni, A Cagan, ... BMC developmental biology 20, 1-20, 2020 | 86 | 2020 |
Identification of genomic variants putatively targeted by selection during dog domestication A Cagan, T Blass BMC evolutionary biology 16, 1-13, 2016 | 78 | 2016 |
Genetic influences on brain gene expression in rats selected for tameness and aggression HO Heyne, S Lautenschläger, R Nelson, F Besnier, M Rotival, A Cagan, ... Genetics 198 (3), 1277-1290, 2014 | 73 | 2014 |
Evolution of the pygmy phenotype: Evidence of positive selection from genome-wide scans in African, Asian, and Melanesian pygmies AB Migliano, IG Romero, M Metspalu, M Leavesley, L Pagani, T Antao, ... Human biology 85 (1-3), 251-284, 2013 | 73 | 2013 |
Natural selection in the great apes A Cagan, C Theunert, H Laayouni, G Santpere, M Pybus, F Casals, ... Molecular biology and evolution 33 (12), 3268-3283, 2016 | 72 | 2016 |