| Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis X Wang, J Venable, P LaPointe, DM Hutt, AV Koulov, J Coppinger, ... Cell 127 (4), 803-815, 2006 | 688 | 2006 |
| Structure of the Sec13/31 COPII coat cage SM Stagg, C Gürkan, DM Fowler, P LaPointe, TR Foss, CS Potter, ... Nature 439 (7073), 234-238, 2006 | 383 | 2006 |
| Structural basis for cargo regulation of COPII coat assembly SM Stagg, P LaPointe, A Razvi, C Gürkan, CS Potter, B Carragher, ... Cell 134 (3), 474-484, 2008 | 292 | 2008 |
| The COPII cage: unifying principles of vesicle coat assembly C Gürkan, SM Stagg, P LaPointe, WE Balch Nature Reviews Molecular Cell Biology 7 (10), 727-738, 2006 | 248 | 2006 |
| Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis AV Koulov, P LaPointe, B Lu, A Razvi, J Coppinger, MQ Dong, J Matteson, ... Molecular biology of the cell 21 (6), 871-884, 2010 | 189 | 2010 |
| Hsp90 regulates the function of argonaute 2 and its recruitment to stress granules and P-bodies JM Pare, N Tahbaz, J López-Orozco, P LaPointe, P Lasko, TC Hobman Molecular biology of the cell 20 (14), 3273-3284, 2009 | 165 | 2009 |
| A role for the protease-sensitive loop region of Shiga-like toxin 1 in the retrotranslocation of its A1 domain from the endoplasmic reticulum lumen P LaPointe, X Wei, J Gariépy Journal of Biological Chemistry 280 (24), 23310-23318, 2005 | 97 | 2005 |
| Structural design of cage and coat scaffolds that direct membrane traffic SM Stagg, P LaPointe, WE Balch Current opinion in structural biology 17 (2), 221-228, 2007 | 78 | 2007 |
| The mechanism of Hsp90 ATPase stimulation by Aha1 A Wolmarans, B Lee, L Spyracopoulos, P LaPointe Scientific reports 6 (1), 33179, 2016 | 73 | 2016 |
| A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation MJ Schellenberg, T Wu, DB Ritchie, S Fica, JP Staley, KA Atta, P LaPointe, ... Nature structural & molecular biology 20 (6), 728-734, 2013 | 54 | 2013 |
| Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNA interference–mediated silencing in mammalian cells JM Pare, P LaPointe, TC Hobman Molecular biology of the cell 24 (15), 2303-2310, 2013 | 46 | 2013 |
| The ER chaperone calnexin controls mitochondrial positioning and respiration T Gutiérrez, H Qi, MC Yap, N Tahbaz, LA Milburn, E Lucchinetti, PH Lou, ... Science Signaling 13 (638), eaax6660, 2020 | 39 | 2020 |
| An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans AD Zuehlke, M Reidy, C Lin, P LaPointe, S Alsomairy, DJ Lee, ... Nature communications 8 (1), 15328, 2017 | 35 | 2017 |
| The co-chaperone Hch1 regulates Hsp90 function differently than its homologue Aha1 and confers sensitivity to yeast to the Hsp90 inhibitor NVP-AUY922 H Armstrong, A Wolmarans, R Mercier, BC Mai, P LaPointe PLoS One 7 (11), e49322, 2012 | 33 | 2012 |
| The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation R Mercier, A Wolmarans, J Schubert, H Neuweiler, JL Johnson, ... Nature Communications 10 (1), 1273, 2019 | 22 | 2019 |
| Treatment of Protein Misfolding W Balch, P LaPointe, J Venable, X Wang, J Yates US Patent App. 11/751,528, 2008 | 21 | 2008 |
| Mise en Place–This Bud's for the Golgi P LaPointe, C Gurkan, WE Balch Molecular cell 14 (4), 413-414, 2004 | 20 | 2004 |
| A mutation in the catalytic loop of hsp90 specifically impairs ATPase stimulation by aha1p, but not hch1p NK Horvat, H Armstrong, BL Lee, R Mercier, A Wolmarans, J Knowles, ... Journal of molecular biology 426 (12), 2379-2392, 2014 | 19 | 2014 |
| Regulation of RNA interference by Hsp90 is an evolutionarily conserved process Y Wang, R Mercier, TC Hobman, P LaPointe Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1833 (12), 2673-2681, 2013 | 19 | 2013 |
| Fluorine-and rhenium-containing geldanamycin derivatives as leads for the development of molecular probes for imaging Hsp90 F Wuest, V Bouvet, BC Mai, P LaPointe Organic & biomolecular chemistry 10 (33), 6724-6731, 2012 | 16 | 2012 |
