Aaron Leconte
Aaron Leconte
Keck Science Dept of the Claremont Colleges
Verified email at - Homepage
Cited by
Cited by
Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet
AM Leconte, GT Hwang, S Matsuda, P Capek, Y Hari, FE Romesberg
Journal of the American Chemical Society 130 (7), 2336-2343, 2008
Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution
BC Dickinson, AM Leconte, B Allen, KM Esvelt, DR Liu
Proceedings of the National Academy of Sciences 110 (22), 9007-9012, 2013
Discovery and biological characterization of geranylated RNA in bacteria
CE Dumelin, Y Chen, AM Leconte, YG Chen, DR Liu
Nature chemical biology 8 (11), 913-919, 2012
Minor groove hydrogen bonds and the replication of unnatural base pairs
S Matsuda, AM Leconte, FE Romesberg
Journal of the American Chemical Society 129 (17), 5551-5557, 2007
Polymerase evolution: efforts toward expansion of the genetic code
AM Leconte, L Chen, FE Romesberg
Journal of the American Chemical Society 127 (36), 12470-12471, 2005
Efforts towards expansion of the genetic alphabet: pyridone and methyl pyridone nucleobases
AM Leconte, S Matsuda, GT Hwang, FE Romesberg
Angewandte Chemie-International Edition 45 (26), 4326-4329, 2006
Stability and polymerase recognition of pyridine nucleobase analogues: Role of minor‐groove H‐bond acceptors
Y Kim, AM Leconte, Y Hari, FE Romesberg
Angewandte Chemie 118 (46), 7973-7976, 2006
A population-based experimental model for protein evolution: effects of mutation rate and selection stringency on evolutionary outcomes
AM Leconte, BC Dickinson, DD Yang, IA Chen, B Allen, DR Liu
Biochemistry 52 (8), 1490-1499, 2013
Directed evolution of DNA polymerases for next generation sequencing
AM Leconte, MP Patel, LE Sass, P McInerney, M Jarosz, L Kung, ...
Angewandte Chemie (International ed. in English) 49 (34), 5921, 2010
An efficiently extended class of unnatural base pairs
AM Leconte, S Matsuda, FE Romesberg
Journal of the American Chemical Society 128 (21), 6780-6781, 2006
Optimization of the pyridyl nucleobase scaffold for polymerase recognition and unnatural base pair replication
Y Hari, GT Hwang, AM Leconte, N Joubert, M Hocek, FE Romesberg
ChemBioChem 9 (17), 2796-2799, 2008
Taq DNA polymerase mutants and 2′-modified sugar recognition
HJ Schultz, AM Gochi, HE Chia, AL Ogonowsky, S Chiang, N Filipovic, ...
Biochemistry 54 (38), 5999-6008, 2015
Synthesis and evaluation of substrate analogue inhibitors of trypanothione reductase
MH Duyzend, CT Clark, SL Simmons, WB Johnson, AM Larson, ...
Journal of Enzyme Inhibition and Medicinal Chemistry 27 (6), 784-794, 2012
Polymerase recognition and stability of fluoro‐substituted pyridone nucleobase analogues
GT Hwang, AM Leconte, FE Romesberg
ChemBioChem 8 (13), 1606-1611, 2007
Statistical coupling analysis-guided library design for the discovery of mutant luciferases
MD Liu, EA Warner, CE Morrissey, CW Fick, TS Wu, MY Ornelas, ...
Biochemistry 57 (5), 663-671, 2018
A broader take on DNA
AM Leconte, FE Romesberg
Nature 444 (7119), 553-555, 2006
Amplify this! DNA and RNA get a third base pair
AM Leconte, FE Romesberg
Nature Methods 3 (9), 667-668, 2006
Design and discovery of new combinations of mutant DNA polymerases and modified DNA substrates
SL Rosenblum, AG Weiden, EL Lewis, AL Ogonowsky, HE Chia, ...
ChemBioChem 18 (8), 816-823, 2017
Engineering nucleobases and polymerases for an expanded genetic alphabet
AM Leconte, FE Romesberg
Protein engineering, 291-313, 2009
Biochemical Analysis Leads to Improved Orthogonal Bioluminescent Tools
SJ Williams, JA Gewing‐Mullins, WK Lieberman, B Kolbaba‐Kartchner, ...
ChemBioChem 24 (6), e202200726, 2023
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