| Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus MJ Sofia, D Bao, W Chang, J Du, D Nagarathnam, S Rachakonda, ... Journal of medicinal chemistry 53 (19), 7202-7218, 2010 | 733 | 2010 |
| Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977 E Murakami, T Tolstykh, H Bao, C Niu, HMM Steuer, D Bao, W Chang, ... Journal of biological chemistry 285 (45), 34337-34347, 2010 | 337 | 2010 |
| Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus AM Lam, C Espiritu, S Bansal, HM Micolochick Steuer, C Niu, V Zennou, ... Antimicrobial agents and chemotherapy 56 (6), 3359-3368, 2012 | 299 | 2012 |
| PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus … AM Lam, E Murakami, C Espiritu, HMM Steuer, C Niu, M Keilman, H Bao, ... Antimicrobial agents and chemotherapy 54 (8), 3187-3196, 2010 | 205 | 2010 |
| Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase AMI Lam, DN Frick Journal of virology 80 (1), 404-411, 2006 | 164 | 2006 |
| High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein K Klumpp, AM Lam, C Lukacs, R Vogel, S Ren, C Espiritu, R Baydo, ... Proceedings of the National Academy of Sciences 112 (49), 15196-15201, 2015 | 146 | 2015 |
| The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently DN Frick, RS Rypma, AMI Lam, B Gu Journal of Biological Chemistry 279 (2), 1269-1280, 2004 | 142 | 2004 |
| Structure of hepatitis C virus polymerase in complex with primer-template RNA RT Mosley, TE Edwards, E Murakami, AM Lam, RL Grice, J Du, MJ Sofia, ... Journal of virology 86 (12), 6503-6511, 2012 | 141 | 2012 |
| Stabilized plasmid-lipid particles: factors influencing plasmid entrapment and transfection properties KWC Mok, AMI Lam, PR Cullis Biochimica et Biophysica Acta (BBA)-Biomembranes 1419 (2), 137-150, 1999 | 121 | 1999 |
| Hepatitis B virus capsid assembly modulators, but not nucleoside analogs, inhibit the production of extracellular pregenomic RNA and spliced RNA variants AM Lam, S Ren, C Espiritu, M Kelly, V Lau, L Zheng, GD Hartman, ... Antimicrobial agents and chemotherapy 61 (8), 10.1128/aac. 00680-17, 2017 | 96 | 2017 |
| Efficacy of NVR 3-778, alone and in combination with pegylated interferon, vs entecavir in uPA/SCID mice with humanized livers and HBV infection K Klumpp, T Shimada, L Allweiss, T Volz, M Lütgehetmann, G Hartman, ... Gastroenterology 154 (3), 652-662. e8, 2018 | 92 | 2018 |
| Calcium enhances the transfection potency of plasmid DNA–cationic liposome complexes AMI Lam, PR Cullis Biochimica et Biophysica Acta (BBA)-Biomembranes 1463 (2), 279-290, 2000 | 89 | 2000 |
| Discovery of PSI-353661, a novel purine nucleotide prodrug for the treatment of HCV infection W Chang, D Bao, BK Chun, D Naduthambi, D Nagarathnam, ... ACS medicinal chemistry letters 2 (2), 130-135, 2011 | 80 | 2011 |
| Two novel conserved motifs in the hepatitis C virus NS3 protein critical for helicase action AMI Lam, D Keeney, DN Frick Journal of Biological Chemistry 278 (45), 44514-44524, 2003 | 78 | 2003 |
| 2′-Deoxy-2′-α-fluoro-2′-β-C-methyl 3′, 5′-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938 PG Reddy, D Bao, W Chang, BK Chun, J Du, D Nagarathnam, ... Bioorganic & Medicinal Chemistry Letters 20 (24), 7376-7380, 2010 | 77 | 2010 |
| Hepatitis C virus NS3 ATPases/helicases from different genotypes exhibit variations in enzymatic properties AMI Lam, D Keeney, PQ Eckert, DN Frick Journal of virology 77 (7), 3950-3961, 2003 | 76 | 2003 |
| Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA AM Lam, C Espiritu, S Bansal, HM Micolochick Steuer, V Zennou, MJ Otto, ... Journal of virology 85 (23), 12334-12342, 2011 | 74 | 2011 |
| Hepatitis B virus-induced modulation of liver macrophage function promotes hepatocyte infection S Faure-Dupuy, M Delphin, L Aillot, L Dimier, F Lebossé, J Fresquet, ... Journal of hepatology 71 (6), 1086-1098, 2019 | 72 | 2019 |
| Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics W Chang, RT Mosley, S Bansal, M Keilman, AM Lam, PA Furman, MJ Otto, ... Bioorganic & medicinal chemistry letters 22 (8), 2938-2942, 2012 | 64 | 2012 |
| Preclinical characterization of NVR 3-778, a first-in-class capsid assembly modulator against hepatitis B virus AM Lam, C Espiritu, R Vogel, S Ren, V Lau, M Kelly, SD Kuduk, ... Antimicrobial agents and chemotherapy 63 (1), 10.1128/aac. 01734-18, 2019 | 60 | 2019 |
David N. FrickUniversity of Wisconsin- MilwaukeeVerified email at uwm.edu
