| Ghrelin TD Müller, R Nogueiras, ML Andermann, ZB Andrews, SD Anker, ... Molecular metabolism 4 (6), 437-460, 2015 | 1009 | 2015 |
| High constitutive signaling of the ghrelin receptor—identification of a potent inverse agonist B Holst, A Cygankiewicz, TH Jensen, M Ankersen, TW Schwartz Molecular endocrinology 17 (11), 2201-2210, 2003 | 565 | 2003 |
| GPR39 signaling is stimulated by zinc ions but not by obestatin B Holst, KL Egerod, E Schild, SP Vickers, S Cheetham, LO Gerlach, ... Endocrinology 148 (1), 13-20, 2007 | 520 | 2007 |
| Molecular mechanism of 7TM receptor activation—a global toggle switch model TW Schwartz, TM Frimurer, B Holst, MM Rosenkilde, CE Elling Annu. Rev. Pharmacol. Toxicol. 46, 481-519, 2006 | 502 | 2006 |
| Ligand binding and micro-switches in 7TM receptor structures R Nygaard, TM Frimurer, B Holst, MM Rosenkilde, TW Schwartz Trends in pharmacological sciences 30 (5), 249-259, 2009 | 436 | 2009 |
| Common structural basis for constitutive activity of the ghrelin receptor family B Holst, ND Holliday, A Bach, CE Elling, HM Cox, TW Schwartz Journal of Biological Chemistry 279 (51), 53806-53817, 2004 | 385 | 2004 |
| FGF21 mediates endocrine control of simple sugar intake and sweet taste preference by the liver S von Holstein-Rathlou, LD BonDurant, L Peltekian, MC Naber, TC Yin, ... Cell metabolism 23 (2), 335-343, 2016 | 347 | 2016 |
| Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation B Holst, TW Schwartz Trends in pharmacological sciences 25 (3), 113-117, 2004 | 300* | 2004 |
| GPR40 (FFAR1)–combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo M Hauge, MA Vestmar, AS Husted, JP Ekberg, MJ Wright, J Di Salvo, ... Molecular metabolism 4 (1), 3-14, 2015 | 220 | 2015 |
| Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act? TW Schwartz, B Holst Trends in pharmacological sciences 28 (8), 366-373, 2007 | 205 | 2007 |
| Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebo-controlled, double-blind, double-crossover study F Strasser, TA Lutz, MT Maeder, B Thuerlimann, D Bueche, M Tschöp, ... British journal of cancer 98 (2), 300-308, 2008 | 198 | 2008 |
| A library of 7TM receptor C-terminal tails: interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive … A Heydorn, BP Søndergaard, B Ersbøll, B Holst, FC Nielsen, CR Haft, ... Journal of Biological Chemistry 279 (52), 54291-54303, 2004 | 191 | 2004 |
| The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo BL Panaro, IR Tough, MS Engelstoft, RT Matthews, GJ Digby, CL Møller, ... Cell metabolism 20 (6), 1018-1029, 2014 | 178 | 2014 |
| A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors 2 B Holst, R Nygaard, L Valentin-Hansen, A Bach, MS Engelstoft, ... Journal of Biological Chemistry 285 (6), 3973-3985, 2010 | 170 | 2010 |
| A gut feeling for obesity: 7TM sensors on enteroendocrine cells MS Engelstoft, KL Egerod, B Holst, TW Schwartz Cell metabolism 8 (6), 447-449, 2008 | 166 | 2008 |
| Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines JB Hansen, MF Tonnesen, AN Madsen, PH Hagedorn, J Friberg, ... Cell metabolism 16 (4), 449-461, 2012 | 165 | 2012 |
| Neurotensin is coexpressed, coreleased, and acts together with GLP-1 and PYY in enteroendocrine control of metabolism KV Grunddal, CF Ratner, B Svendsen, F Sommer, MS Engelstoft, ... Endocrinology 157 (1), 176-194, 2016 | 150 | 2016 |
| Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling B Holst, E Brandt, A Bach, A Heding, TW Schwartz Molecular endocrinology 19 (9), 2400-2411, 2005 | 144 | 2005 |
| Conversion of agonist site to metal-ion chelator site in the β2-adrenergic receptor CE Elling, K Thirstrup, B Holst, TW Schwartz Proceedings of the National Academy of Sciences 96 (22), 12322-12327, 1999 | 140 | 1999 |
| Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity PJ Holst, MM Rosenkilde, D Manfra, SC Chen, MT Wiekowski, B Holst, ... The Journal of clinical investigation 108 (12), 1789-1796, 2001 | 134 | 2001 |
Annette Beck-SickingerProfessor of Biochemistry, Leipzig UniversityAdresse e-mail validée de uni-leipzig.de
